Final published version
Research output: Contribution to Journal/Magazine › Review article › peer-review
Research output: Contribution to Journal/Magazine › Review article › peer-review
}
TY - JOUR
T1 - Spectroscopic techniques as potential screening tools for preterm birth
T2 - A review and an exploratory study
AU - Narice, B. F.
AU - Martínez, M. A.García
AU - Amabebe, E.
AU - Pacheco, D. Lazaro
AU - Rehman, I. U.
AU - Anumba, D. O.
PY - 2019/4/21
Y1 - 2019/4/21
N2 - Preterm birth (PTB) is the single-most important determinant of infant adverse outcome worldwide, accounting for over 1 million neonatal deaths a year. Given its complex pathophysiology, prediction and prevention of PTB remain elusive. Current screening methods lack accuracy and reliability, and have failed to reduce the incidence and consequences of PTB. Hence, there remains a real need to develop noninvasive and more cost-effective screening tests, which can facilitate earlier identification of women at greatest risk, more timely prevention, and better risk stratification and management of PTB. Spectroscopic techniques have shown great promise to meet this demand. Therefore, in this article, the literature is reviewed to assess current evidence regarding the potential application of spectroscopic techniques to predict PTB via in vitro analysis of biofluids as well as in vivo study of cervical remodeling. In addition, preliminary data exploring the use of Raman spectroscopy (RS) to analyze cervicovaginal fluid (CVF) in pregnancy as a predictive tool for PTB is detailed for the first time with the aim to inform future avenues of research.
AB - Preterm birth (PTB) is the single-most important determinant of infant adverse outcome worldwide, accounting for over 1 million neonatal deaths a year. Given its complex pathophysiology, prediction and prevention of PTB remain elusive. Current screening methods lack accuracy and reliability, and have failed to reduce the incidence and consequences of PTB. Hence, there remains a real need to develop noninvasive and more cost-effective screening tests, which can facilitate earlier identification of women at greatest risk, more timely prevention, and better risk stratification and management of PTB. Spectroscopic techniques have shown great promise to meet this demand. Therefore, in this article, the literature is reviewed to assess current evidence regarding the potential application of spectroscopic techniques to predict PTB via in vitro analysis of biofluids as well as in vivo study of cervical remodeling. In addition, preliminary data exploring the use of Raman spectroscopy (RS) to analyze cervicovaginal fluid (CVF) in pregnancy as a predictive tool for PTB is detailed for the first time with the aim to inform future avenues of research.
KW - Preterm birth
KW - spectroscopy
KW - biofluids
KW - cervical remodelling
KW - prediction
U2 - 10.1080/05704928.2018.1473873
DO - 10.1080/05704928.2018.1473873
M3 - Review article
AN - SCOPUS:85067619142
VL - 54
SP - 348
EP - 367
JO - APPLIED SPECTROSCOPY REVIEWS
JF - APPLIED SPECTROSCOPY REVIEWS
SN - 0570-4928
IS - 4
ER -