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    Rights statement: This is the author’s version of a work that was accepted for publication in Journal of Chemical Neuroanatomy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Chemical Neuroanatomy, 111, 2020 DOI: 10.1016/j.jchemneu.2020.101883

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Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus

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Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus. / Pałasz, A.; Suszka-Świtek, A.; Kaśkosz, A. et al.
In: Journal of Chemical Neuroanatomy, Vol. 111, 101883, 01.01.2021.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Pałasz, A, Suszka-Świtek, A, Kaśkosz, A, Plewka, D, Bogus, K, Filipczyk, Ł, Błaszczyk, I, Bacopoulou, F, Worthington, JJ, Piwowarczyk-Nowak, A, Tyszkiewicz-Nwafor, M & Wiaderkiewicz, R 2021, 'Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus', Journal of Chemical Neuroanatomy, vol. 111, 101883. https://doi.org/10.1016/j.jchemneu.2020.101883

APA

Pałasz, A., Suszka-Świtek, A., Kaśkosz, A., Plewka, D., Bogus, K., Filipczyk, Ł., Błaszczyk, I., Bacopoulou, F., Worthington, J. J., Piwowarczyk-Nowak, A., Tyszkiewicz-Nwafor, M., & Wiaderkiewicz, R. (2021). Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus. Journal of Chemical Neuroanatomy, 111, Article 101883. https://doi.org/10.1016/j.jchemneu.2020.101883

Vancouver

Pałasz A, Suszka-Świtek A, Kaśkosz A, Plewka D, Bogus K, Filipczyk Ł et al. Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus. Journal of Chemical Neuroanatomy. 2021 Jan 1;111:101883. Epub 2020 Nov 5. doi: 10.1016/j.jchemneu.2020.101883

Author

Pałasz, A. ; Suszka-Świtek, A. ; Kaśkosz, A. et al. / Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus. In: Journal of Chemical Neuroanatomy. 2021 ; Vol. 111.

Bibtex

@article{caba929fa4a34155bcad84f1406650f6,
title = "Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus",
abstract = "Neuropeptides are involved in numerous brain activities being responsible for a wide spectrum of higher mental functions. The purpose of this concise, structural and qualitative investigation was to map the possible immunoreactivity of the novel neuropeptide spexin (SPX) within the human magnocellular hypothalamus. SPX is a newly identified peptide, a natural ligand for the galanin receptors (GALR) 2/3, with no molecular structure similarities to currently known regulatory factors. SPX seems to have multiple physiological functions, with an involvement in reproduction and food-intake regulation recently revealed in animal studies. For the first time we describe SPX expressing neurons in the supraoptic (SON) and paraventricular (PVN) nuclei of the human hypothalamus using immunohistochemical and fluorescent methods, key regions involved in the mechanisms of osmotic homeostasis, energy expenditure, consummatory behaviour, reproductive processes, social recognition and stress responses. The vast majority of neurons located in both examined neurosecretory nuclei show abundant SPX expression and this may indirectly implicate a potential contribution of SPX signalling to the hypothalamic physiology in the human brain. {\textcopyright} 2020 Elsevier B.V.",
keywords = "Brain, Hypothalamus, Neuropeptides, Spexin",
author = "A. Pa{\l}asz and A. Suszka-{\'S}witek and A. Ka{\'s}kosz and D. Plewka and K. Bogus and {\L}. Filipczyk and I. B{\l}aszczyk and F. Bacopoulou and J.J. Worthington and A. Piwowarczyk-Nowak and M. Tyszkiewicz-Nwafor and R. Wiaderkiewicz",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Journal of Chemical Neuroanatomy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Chemical Neuroanatomy, 111, 2020 DOI: 10.1016/j.jchemneu.2020.101883",
year = "2021",
month = jan,
day = "1",
doi = "10.1016/j.jchemneu.2020.101883",
language = "English",
volume = "111",
journal = "Journal of Chemical Neuroanatomy",

}

RIS

TY - JOUR

T1 - Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus

AU - Pałasz, A.

AU - Suszka-Świtek, A.

AU - Kaśkosz, A.

AU - Plewka, D.

AU - Bogus, K.

AU - Filipczyk, Ł.

AU - Błaszczyk, I.

AU - Bacopoulou, F.

AU - Worthington, J.J.

AU - Piwowarczyk-Nowak, A.

AU - Tyszkiewicz-Nwafor, M.

AU - Wiaderkiewicz, R.

N1 - This is the author’s version of a work that was accepted for publication in Journal of Chemical Neuroanatomy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Chemical Neuroanatomy, 111, 2020 DOI: 10.1016/j.jchemneu.2020.101883

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Neuropeptides are involved in numerous brain activities being responsible for a wide spectrum of higher mental functions. The purpose of this concise, structural and qualitative investigation was to map the possible immunoreactivity of the novel neuropeptide spexin (SPX) within the human magnocellular hypothalamus. SPX is a newly identified peptide, a natural ligand for the galanin receptors (GALR) 2/3, with no molecular structure similarities to currently known regulatory factors. SPX seems to have multiple physiological functions, with an involvement in reproduction and food-intake regulation recently revealed in animal studies. For the first time we describe SPX expressing neurons in the supraoptic (SON) and paraventricular (PVN) nuclei of the human hypothalamus using immunohistochemical and fluorescent methods, key regions involved in the mechanisms of osmotic homeostasis, energy expenditure, consummatory behaviour, reproductive processes, social recognition and stress responses. The vast majority of neurons located in both examined neurosecretory nuclei show abundant SPX expression and this may indirectly implicate a potential contribution of SPX signalling to the hypothalamic physiology in the human brain. © 2020 Elsevier B.V.

AB - Neuropeptides are involved in numerous brain activities being responsible for a wide spectrum of higher mental functions. The purpose of this concise, structural and qualitative investigation was to map the possible immunoreactivity of the novel neuropeptide spexin (SPX) within the human magnocellular hypothalamus. SPX is a newly identified peptide, a natural ligand for the galanin receptors (GALR) 2/3, with no molecular structure similarities to currently known regulatory factors. SPX seems to have multiple physiological functions, with an involvement in reproduction and food-intake regulation recently revealed in animal studies. For the first time we describe SPX expressing neurons in the supraoptic (SON) and paraventricular (PVN) nuclei of the human hypothalamus using immunohistochemical and fluorescent methods, key regions involved in the mechanisms of osmotic homeostasis, energy expenditure, consummatory behaviour, reproductive processes, social recognition and stress responses. The vast majority of neurons located in both examined neurosecretory nuclei show abundant SPX expression and this may indirectly implicate a potential contribution of SPX signalling to the hypothalamic physiology in the human brain. © 2020 Elsevier B.V.

KW - Brain

KW - Hypothalamus

KW - Neuropeptides

KW - Spexin

U2 - 10.1016/j.jchemneu.2020.101883

DO - 10.1016/j.jchemneu.2020.101883

M3 - Journal article

VL - 111

JO - Journal of Chemical Neuroanatomy

JF - Journal of Chemical Neuroanatomy

M1 - 101883

ER -