Rights statement: This is the author’s version of a work that was accepted for publication in Journal of Chemical Neuroanatomy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Chemical Neuroanatomy, 111, 2020 DOI: 10.1016/j.jchemneu.2020.101883
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Available under license: CC BY-NC-ND
Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus
AU - Pałasz, A.
AU - Suszka-Świtek, A.
AU - Kaśkosz, A.
AU - Plewka, D.
AU - Bogus, K.
AU - Filipczyk, Ł.
AU - Błaszczyk, I.
AU - Bacopoulou, F.
AU - Worthington, J.J.
AU - Piwowarczyk-Nowak, A.
AU - Tyszkiewicz-Nwafor, M.
AU - Wiaderkiewicz, R.
N1 - This is the author’s version of a work that was accepted for publication in Journal of Chemical Neuroanatomy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Chemical Neuroanatomy, 111, 2020 DOI: 10.1016/j.jchemneu.2020.101883
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Neuropeptides are involved in numerous brain activities being responsible for a wide spectrum of higher mental functions. The purpose of this concise, structural and qualitative investigation was to map the possible immunoreactivity of the novel neuropeptide spexin (SPX) within the human magnocellular hypothalamus. SPX is a newly identified peptide, a natural ligand for the galanin receptors (GALR) 2/3, with no molecular structure similarities to currently known regulatory factors. SPX seems to have multiple physiological functions, with an involvement in reproduction and food-intake regulation recently revealed in animal studies. For the first time we describe SPX expressing neurons in the supraoptic (SON) and paraventricular (PVN) nuclei of the human hypothalamus using immunohistochemical and fluorescent methods, key regions involved in the mechanisms of osmotic homeostasis, energy expenditure, consummatory behaviour, reproductive processes, social recognition and stress responses. The vast majority of neurons located in both examined neurosecretory nuclei show abundant SPX expression and this may indirectly implicate a potential contribution of SPX signalling to the hypothalamic physiology in the human brain. © 2020 Elsevier B.V.
AB - Neuropeptides are involved in numerous brain activities being responsible for a wide spectrum of higher mental functions. The purpose of this concise, structural and qualitative investigation was to map the possible immunoreactivity of the novel neuropeptide spexin (SPX) within the human magnocellular hypothalamus. SPX is a newly identified peptide, a natural ligand for the galanin receptors (GALR) 2/3, with no molecular structure similarities to currently known regulatory factors. SPX seems to have multiple physiological functions, with an involvement in reproduction and food-intake regulation recently revealed in animal studies. For the first time we describe SPX expressing neurons in the supraoptic (SON) and paraventricular (PVN) nuclei of the human hypothalamus using immunohistochemical and fluorescent methods, key regions involved in the mechanisms of osmotic homeostasis, energy expenditure, consummatory behaviour, reproductive processes, social recognition and stress responses. The vast majority of neurons located in both examined neurosecretory nuclei show abundant SPX expression and this may indirectly implicate a potential contribution of SPX signalling to the hypothalamic physiology in the human brain. © 2020 Elsevier B.V.
KW - Brain
KW - Hypothalamus
KW - Neuropeptides
KW - Spexin
U2 - 10.1016/j.jchemneu.2020.101883
DO - 10.1016/j.jchemneu.2020.101883
M3 - Journal article
VL - 111
JO - Journal of Chemical Neuroanatomy
JF - Journal of Chemical Neuroanatomy
M1 - 101883
ER -