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S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.

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S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. / Lindsay, Howard, D.; Griffiths, Dominic J. F.; Edwards, Rhian J.; Christensen, Per U.; Murray, Johanne M.; Osman, Fekret; Walworth, Nancy; Carr, Antony M.

In: Genes and Development, Vol. 12, No. 3, 01.02.1998, p. 382-395.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Lindsay, HD, Griffiths, DJF, Edwards, RJ, Christensen, PU, Murray, JM, Osman, F, Walworth, N & Carr, AM 1998, 'S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.', Genes and Development, vol. 12, no. 3, pp. 382-395. <http://genesdev.cshlp.org/content/12/3/382.long>

APA

Lindsay, H. D., Griffiths, D. J. F., Edwards, R. J., Christensen, P. U., Murray, J. M., Osman, F., Walworth, N., & Carr, A. M. (1998). S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Genes and Development, 12(3), 382-395. http://genesdev.cshlp.org/content/12/3/382.long

Vancouver

Lindsay HD, Griffiths DJF, Edwards RJ, Christensen PU, Murray JM, Osman F et al. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Genes and Development. 1998 Feb 1;12(3):382-395.

Author

Lindsay, Howard, D. ; Griffiths, Dominic J. F. ; Edwards, Rhian J. ; Christensen, Per U. ; Murray, Johanne M. ; Osman, Fekret ; Walworth, Nancy ; Carr, Antony M. / S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. In: Genes and Development. 1998 ; Vol. 12, No. 3. pp. 382-395.

Bibtex

@article{cec259d399cf4349bd2a6aea7e4c745b,
title = "S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.",
abstract = "Checkpoints that respond to DNA structure changes were originally defined by the inability of yeast mutants to prevent mitosis following DNA damage or S-phase arrest. Genetic analysis has subsequently identified subpathways of the DNA structure checkpoints, including the reversible arrest of DNA synthesis. Here, we show that the Cds1 kinase is required to slow S phase in the presence of DNA-damaging agents. Cds1 is phosphorylated and activated by S-phase arrest and activated by DNA damage during S phase, but not during G1 or G2. Activation of Cds1 during S phase is dependent on all six checkpoint Rad proteins, and Cds1 interacts both genetically and physically with Rad26. Unlike its Saccharomyces cerevisiae counterpart Rad53, Cds1 is not required for the mitotic arrest checkpoints and, thus, defines an S-phase specific subpathway of the checkpoint response. We propose a model for the DNA structure checkpoints that offers a new perspective on the function of the DNA structure checkpoint proteins. This model suggests that an intrinsic mechanism linking S phase and mitosis may function independently of the known checkpoint proteins.",
author = "Lindsay, {Howard, D.} and Griffiths, {Dominic J. F.} and Edwards, {Rhian J.} and Christensen, {Per U.} and Murray, {Johanne M.} and Fekret Osman and Nancy Walworth and Carr, {Antony M.}",
year = "1998",
month = feb,
day = "1",
language = "English",
volume = "12",
pages = "382--395",
journal = "Genes and Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "3",

}

RIS

TY - JOUR

T1 - S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.

AU - Lindsay, Howard, D.

AU - Griffiths, Dominic J. F.

AU - Edwards, Rhian J.

AU - Christensen, Per U.

AU - Murray, Johanne M.

AU - Osman, Fekret

AU - Walworth, Nancy

AU - Carr, Antony M.

PY - 1998/2/1

Y1 - 1998/2/1

N2 - Checkpoints that respond to DNA structure changes were originally defined by the inability of yeast mutants to prevent mitosis following DNA damage or S-phase arrest. Genetic analysis has subsequently identified subpathways of the DNA structure checkpoints, including the reversible arrest of DNA synthesis. Here, we show that the Cds1 kinase is required to slow S phase in the presence of DNA-damaging agents. Cds1 is phosphorylated and activated by S-phase arrest and activated by DNA damage during S phase, but not during G1 or G2. Activation of Cds1 during S phase is dependent on all six checkpoint Rad proteins, and Cds1 interacts both genetically and physically with Rad26. Unlike its Saccharomyces cerevisiae counterpart Rad53, Cds1 is not required for the mitotic arrest checkpoints and, thus, defines an S-phase specific subpathway of the checkpoint response. We propose a model for the DNA structure checkpoints that offers a new perspective on the function of the DNA structure checkpoint proteins. This model suggests that an intrinsic mechanism linking S phase and mitosis may function independently of the known checkpoint proteins.

AB - Checkpoints that respond to DNA structure changes were originally defined by the inability of yeast mutants to prevent mitosis following DNA damage or S-phase arrest. Genetic analysis has subsequently identified subpathways of the DNA structure checkpoints, including the reversible arrest of DNA synthesis. Here, we show that the Cds1 kinase is required to slow S phase in the presence of DNA-damaging agents. Cds1 is phosphorylated and activated by S-phase arrest and activated by DNA damage during S phase, but not during G1 or G2. Activation of Cds1 during S phase is dependent on all six checkpoint Rad proteins, and Cds1 interacts both genetically and physically with Rad26. Unlike its Saccharomyces cerevisiae counterpart Rad53, Cds1 is not required for the mitotic arrest checkpoints and, thus, defines an S-phase specific subpathway of the checkpoint response. We propose a model for the DNA structure checkpoints that offers a new perspective on the function of the DNA structure checkpoint proteins. This model suggests that an intrinsic mechanism linking S phase and mitosis may function independently of the known checkpoint proteins.

M3 - Journal article

VL - 12

SP - 382

EP - 395

JO - Genes and Development

JF - Genes and Development

SN - 0890-9369

IS - 3

ER -