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Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling. / Lin, Hungyen; Pei, Chunlei; Markl, Daniel et al.
In: IET Microwaves, Antennas and Propagation, Vol. 12, No. 11, 27.08.2018, p. 1775-1779.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Lin, H, Pei, C, Markl, D, Shen, Y, Elliott, JA & Zeitler, JA 2018, 'Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling', IET Microwaves, Antennas and Propagation, vol. 12, no. 11, pp. 1775-1779. https://doi.org/10.1049/iet-map.2018.5561

APA

Lin, H., Pei, C., Markl, D., Shen, Y., Elliott, J. A., & Zeitler, J. A. (2018). Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling. IET Microwaves, Antennas and Propagation, 12(11), 1775-1779. https://doi.org/10.1049/iet-map.2018.5561

Vancouver

Lin H, Pei C, Markl D, Shen Y, Elliott JA, Zeitler JA. Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling. IET Microwaves, Antennas and Propagation. 2018 Aug 27;12(11):1775-1779. doi: 10.1049/iet-map.2018.5561

Author

Lin, Hungyen ; Pei, Chunlei ; Markl, Daniel et al. / Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling. In: IET Microwaves, Antennas and Propagation. 2018 ; Vol. 12, No. 11. pp. 1775-1779.

Bibtex

@article{1814d5ca16b24db8a4ab4682637121c4,
title = "Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling",
abstract = "In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis. {\textcopyright} The Institution of Engineering and Technology 2018.",
keywords = "Dielectric losses, Mixing, pH effects, Ray tracing, Thickness measurement, Coating process, Discrete Element Modelling, In-line measurements, Line measurements, Numerical verification, Pharmaceutical tablets, Ray-tracing method, Selection criteria, Coatings",
author = "Hungyen Lin and Chunlei Pei and Daniel Markl and Yaochun Shen and Elliott, {James A.} and Zeitler, {J Axel}",
year = "2018",
month = aug,
day = "27",
doi = "10.1049/iet-map.2018.5561",
language = "English",
volume = "12",
pages = "1775--1779",
journal = "IET Microwaves, Antennas and Propagation",
issn = "1751-8733",
publisher = "Institution of Engineering and Technology",
number = "11",

}

RIS

TY - JOUR

T1 - Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling

AU - Lin, Hungyen

AU - Pei, Chunlei

AU - Markl, Daniel

AU - Shen, Yaochun

AU - Elliott, James A.

AU - Zeitler, J Axel

PY - 2018/8/27

Y1 - 2018/8/27

N2 - In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis. © The Institution of Engineering and Technology 2018.

AB - In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis. © The Institution of Engineering and Technology 2018.

KW - Dielectric losses

KW - Mixing

KW - pH effects

KW - Ray tracing

KW - Thickness measurement

KW - Coating process

KW - Discrete Element Modelling

KW - In-line measurements

KW - Line measurements

KW - Numerical verification

KW - Pharmaceutical tablets

KW - Ray-tracing method

KW - Selection criteria

KW - Coatings

U2 - 10.1049/iet-map.2018.5561

DO - 10.1049/iet-map.2018.5561

M3 - Journal article

VL - 12

SP - 1775

EP - 1779

JO - IET Microwaves, Antennas and Propagation

JF - IET Microwaves, Antennas and Propagation

SN - 1751-8733

IS - 11

ER -