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Stereocontrolled synthesis of the aconitine D ring from d -glucose

Research output: Contribution to Journal/Magazine › Journal article › peer-review

E-pub ahead of print
  • Ian A. Pocock
  • Julien Doulcet
  • Craig R. Rice
  • Joseph B. Sweeney
  • Duncan M. Gill
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<mark>Journal publication date</mark>3/05/2024
<mark>Journal</mark>Organic and Biomolecular Chemistry
Publication StatusE-pub ahead of print
Early online date3/05/24
<mark>Original language</mark>English

Abstract

The synthesis of a fully oxygenated aconitine D ring precursor from (d)-(+)-glucose is described. The route features a highly diastereoselective alkynyl Grignard ketone addition and a base-mediated enelactone to 1,3-diketone rearrangement.