Home > Research > Publications & Outputs > Structural characterization by x-ray methods of...

Research

Links

Text available via DOI:

Keywords

View graph of relations

Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. / Pickup, D. M.; Moss, R. M.; Qiu, D. et al.
In: Journal of Chemical Physics, Vol. 130, No. 6, 064708, 01.02.2009.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Pickup, DM, Moss, RM, Qiu, D, Newport, RJ, Valappil, SP, Knowles, JC & Smith, ME 2009, 'Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses', Journal of Chemical Physics, vol. 130, no. 6, 064708. https://doi.org/10.1063/1.3076057

APA

Pickup, D. M., Moss, R. M., Qiu, D., Newport, R. J., Valappil, S. P., Knowles, J. C., & Smith, M. E. (2009). Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. Journal of Chemical Physics, 130(6), Article 064708. https://doi.org/10.1063/1.3076057

Vancouver

Pickup DM, Moss RM, Qiu D, Newport RJ, Valappil SP, Knowles JC et al. Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. Journal of Chemical Physics. 2009 Feb 1;130(6):064708. doi: 10.1063/1.3076057

Author

Pickup, D. M. ; Moss, R. M. ; Qiu, D. et al. / Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. In: Journal of Chemical Physics. 2009 ; Vol. 130, No. 6.

Bibtex

@article{ca809c6f31154aa4a2a7a71fd422417c,
title = "Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses",
abstract = "Antimicrobial gallium-doped phosphate-based glasses of general composition (P2O5)(0.45)(CaO)(0.16)(Na2O)(0.39-x)(Ga2O3)(x) (where x=0, 0.01, 0.03, and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-ray diffraction to provide a structural insight into their unique properties. The results show that the Ga3+ ions are octahedrally coordinated. Furthermore, substitution of Na2O by Ga2O3 strengthens the phosphate network structure because the presence of GaO6 octahedra inhibits the migration of the remaining Na+ ions. The results are discussed in terms of the use of Na2O-CaO-P2O5 glasses as controlled-delivery devices for antimicrobial Ga3+ ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron.",
keywords = "antibacterial activity, biomedical materials, calcium compounds, cellular biophysics, dissolving, gallium, microorganisms, phosphate glasses, sodium compounds, X-ray absorption spectra, X-ray diffraction",
author = "Pickup, {D. M.} and Moss, {R. M.} and D. Qiu and Newport, {R. J.} and Valappil, {S. P.} and Knowles, {J. C.} and Smith, {Mark E.}",
year = "2009",
month = feb,
day = "1",
doi = "10.1063/1.3076057",
language = "English",
volume = "130",
journal = "Journal of Chemical Physics",
issn = "1089-7690",
publisher = "AMER INST PHYSICS",
number = "6",

}

RIS

TY - JOUR

T1 - Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses

AU - Pickup, D. M.

AU - Moss, R. M.

AU - Qiu, D.

AU - Newport, R. J.

AU - Valappil, S. P.

AU - Knowles, J. C.

AU - Smith, Mark E.

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Antimicrobial gallium-doped phosphate-based glasses of general composition (P2O5)(0.45)(CaO)(0.16)(Na2O)(0.39-x)(Ga2O3)(x) (where x=0, 0.01, 0.03, and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-ray diffraction to provide a structural insight into their unique properties. The results show that the Ga3+ ions are octahedrally coordinated. Furthermore, substitution of Na2O by Ga2O3 strengthens the phosphate network structure because the presence of GaO6 octahedra inhibits the migration of the remaining Na+ ions. The results are discussed in terms of the use of Na2O-CaO-P2O5 glasses as controlled-delivery devices for antimicrobial Ga3+ ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron.

AB - Antimicrobial gallium-doped phosphate-based glasses of general composition (P2O5)(0.45)(CaO)(0.16)(Na2O)(0.39-x)(Ga2O3)(x) (where x=0, 0.01, 0.03, and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-ray diffraction to provide a structural insight into their unique properties. The results show that the Ga3+ ions are octahedrally coordinated. Furthermore, substitution of Na2O by Ga2O3 strengthens the phosphate network structure because the presence of GaO6 octahedra inhibits the migration of the remaining Na+ ions. The results are discussed in terms of the use of Na2O-CaO-P2O5 glasses as controlled-delivery devices for antimicrobial Ga3+ ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron.

KW - antibacterial activity, biomedical materials, calcium compounds, cellular biophysics, dissolving, gallium, microorganisms, phosphate glasses, sodium compounds, X-ray absorption spectra, X-ray diffraction

U2 - 10.1063/1.3076057

DO - 10.1063/1.3076057

M3 - Journal article

VL - 130

JO - Journal of Chemical Physics

JF - Journal of Chemical Physics

SN - 1089-7690

IS - 6

M1 - 064708

ER -