Home > Research > Publications & Outputs > Structural, mechanical, and biocompatibility an...

Links

Text available via DOI:

View graph of relations

Structural, mechanical, and biocompatibility analyses of a novel dental restorative nanocomposite

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published

Standard

Structural, mechanical, and biocompatibility analyses of a novel dental restorative nanocomposite. / Khan, A.S.; Wong, F.S.L.; McKay, I.J.; Whiley, R.A.; Rehman, I.U.

In: Journal of Applied Polymer Science, Vol. 127, No. 1, 2013, p. 439-447.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Khan, AS, Wong, FSL, McKay, IJ, Whiley, RA & Rehman, IU 2013, 'Structural, mechanical, and biocompatibility analyses of a novel dental restorative nanocomposite', Journal of Applied Polymer Science, vol. 127, no. 1, pp. 439-447. https://doi.org/10.1002/app.37841

APA

Khan, A. S., Wong, F. S. L., McKay, I. J., Whiley, R. A., & Rehman, I. U. (2013). Structural, mechanical, and biocompatibility analyses of a novel dental restorative nanocomposite. Journal of Applied Polymer Science, 127(1), 439-447. https://doi.org/10.1002/app.37841

Vancouver

Khan AS, Wong FSL, McKay IJ, Whiley RA, Rehman IU. Structural, mechanical, and biocompatibility analyses of a novel dental restorative nanocomposite. Journal of Applied Polymer Science. 2013;127(1):439-447. https://doi.org/10.1002/app.37841

Author

Khan, A.S. ; Wong, F.S.L. ; McKay, I.J. ; Whiley, R.A. ; Rehman, I.U. / Structural, mechanical, and biocompatibility analyses of a novel dental restorative nanocomposite. In: Journal of Applied Polymer Science. 2013 ; Vol. 127, No. 1. pp. 439-447.

Bibtex

@article{0253fe28e63a438db8c5570a4e11c347,
title = "Structural, mechanical, and biocompatibility analyses of a novel dental restorative nanocomposite",
abstract = "Structure and biocompatibility are key parameters that determine the usefulness of dental materials for clinical use. Novel polyurethane (PU) nanocomposite material was prepared by chemically binding nanohydroxyapatite (nHA) to the diisocyanate component of the PU backbone by solvent- polymerization. nHA was incorporated into PU by the stepwise addition of monomeric units of the PU. The PU/nHA composite was analyzed by 13C Nuclear magnetic resonance (structural) and X-ray diffraction (phase analysis). The tensile strength and elastic modulus was evaluated for mechanical properties. These analyses revealed linkage between the hard- and soft-segments are urethane linkage and showed high mechanical properties with increase in content of nHA. To assess biocompatibility osteoblast cells were seeded on to the material and allowed to adhere and proliferate. Osteoblast-like cell growth and proliferation was assessed by MTS assay. It was found that cells adhered and proliferated on these novel substrates. To test bacterial adhesion discs of composite with and without nHA were incubated with standardized suspensions of oral bacterium Streptococcus sanguinis strain NCTC 7863. PU composites with nHA exhibited biocompatibility with respect to mammalian cell growth and showed significantly reduced bacterial adhesion as compared to PU alone. Copyright {\textcopyright} 2012 Wiley Periodicals, Inc.",
keywords = "biocompatibility, mechanical properties, nanohydroxyapatite, polyurethane, structural analysis, Bacterial adhesion, Clinical use, Diisocyanates, High mechanical properties, Key parameters, Mammalian cells, Monomeric units, Nano-hydroxyapatite, Oral bacteria, Osteoblast cells, Osteoblast-like cells, Phase analysis, Soft segments, Urethane linkage, Adhesion, Aerobic bacteria, Cell growth, Dental materials, Growth kinetics, Mechanical properties, Nanocomposites, Polyurethanes, Structural analysis, X ray diffraction, Biocompatibility",
author = "A.S. Khan and F.S.L. Wong and I.J. McKay and R.A. Whiley and I.U. Rehman",
year = "2013",
doi = "10.1002/app.37841",
language = "English",
volume = "127",
pages = "439--447",
journal = "Journal of Applied Polymer Science",
issn = "0021-8995",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Structural, mechanical, and biocompatibility analyses of a novel dental restorative nanocomposite

AU - Khan, A.S.

AU - Wong, F.S.L.

AU - McKay, I.J.

AU - Whiley, R.A.

AU - Rehman, I.U.

PY - 2013

Y1 - 2013

N2 - Structure and biocompatibility are key parameters that determine the usefulness of dental materials for clinical use. Novel polyurethane (PU) nanocomposite material was prepared by chemically binding nanohydroxyapatite (nHA) to the diisocyanate component of the PU backbone by solvent- polymerization. nHA was incorporated into PU by the stepwise addition of monomeric units of the PU. The PU/nHA composite was analyzed by 13C Nuclear magnetic resonance (structural) and X-ray diffraction (phase analysis). The tensile strength and elastic modulus was evaluated for mechanical properties. These analyses revealed linkage between the hard- and soft-segments are urethane linkage and showed high mechanical properties with increase in content of nHA. To assess biocompatibility osteoblast cells were seeded on to the material and allowed to adhere and proliferate. Osteoblast-like cell growth and proliferation was assessed by MTS assay. It was found that cells adhered and proliferated on these novel substrates. To test bacterial adhesion discs of composite with and without nHA were incubated with standardized suspensions of oral bacterium Streptococcus sanguinis strain NCTC 7863. PU composites with nHA exhibited biocompatibility with respect to mammalian cell growth and showed significantly reduced bacterial adhesion as compared to PU alone. Copyright © 2012 Wiley Periodicals, Inc.

AB - Structure and biocompatibility are key parameters that determine the usefulness of dental materials for clinical use. Novel polyurethane (PU) nanocomposite material was prepared by chemically binding nanohydroxyapatite (nHA) to the diisocyanate component of the PU backbone by solvent- polymerization. nHA was incorporated into PU by the stepwise addition of monomeric units of the PU. The PU/nHA composite was analyzed by 13C Nuclear magnetic resonance (structural) and X-ray diffraction (phase analysis). The tensile strength and elastic modulus was evaluated for mechanical properties. These analyses revealed linkage between the hard- and soft-segments are urethane linkage and showed high mechanical properties with increase in content of nHA. To assess biocompatibility osteoblast cells were seeded on to the material and allowed to adhere and proliferate. Osteoblast-like cell growth and proliferation was assessed by MTS assay. It was found that cells adhered and proliferated on these novel substrates. To test bacterial adhesion discs of composite with and without nHA were incubated with standardized suspensions of oral bacterium Streptococcus sanguinis strain NCTC 7863. PU composites with nHA exhibited biocompatibility with respect to mammalian cell growth and showed significantly reduced bacterial adhesion as compared to PU alone. Copyright © 2012 Wiley Periodicals, Inc.

KW - biocompatibility

KW - mechanical properties

KW - nanohydroxyapatite

KW - polyurethane

KW - structural analysis

KW - Bacterial adhesion

KW - Clinical use

KW - Diisocyanates

KW - High mechanical properties

KW - Key parameters

KW - Mammalian cells

KW - Monomeric units

KW - Nano-hydroxyapatite

KW - Oral bacteria

KW - Osteoblast cells

KW - Osteoblast-like cells

KW - Phase analysis

KW - Soft segments

KW - Urethane linkage

KW - Adhesion

KW - Aerobic bacteria

KW - Cell growth

KW - Dental materials

KW - Growth kinetics

KW - Mechanical properties

KW - Nanocomposites

KW - Polyurethanes

KW - Structural analysis

KW - X ray diffraction

KW - Biocompatibility

U2 - 10.1002/app.37841

DO - 10.1002/app.37841

M3 - Journal article

VL - 127

SP - 439

EP - 447

JO - Journal of Applied Polymer Science

JF - Journal of Applied Polymer Science

SN - 0021-8995

IS - 1

ER -