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Studies on the oxidative polymerization of homogentisic acid to form pyomelanin.

Research output: Contribution to conference - Without ISBN/ISSN › Poster

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Studies on the oxidative polymerization of homogentisic acid to form pyomelanin. / Galeb, Hanaa; Hardy, John.

2021. Poster session presented at Science Week 2021.

Research output: Contribution to conference - Without ISBN/ISSN › Poster

Harvard

Galeb, H & Hardy, J 2021, 'Studies on the oxidative polymerization of homogentisic acid to form pyomelanin.', Science Week 2021, 12/04/21 - 16/04/21.

APA

Galeb, H., & Hardy, J. (2021). Studies on the oxidative polymerization of homogentisic acid to form pyomelanin.. Poster session presented at Science Week 2021.

Vancouver

Galeb H, Hardy J. Studies on the oxidative polymerization of homogentisic acid to form pyomelanin.. 2021. Poster session presented at Science Week 2021.

Author

Galeb, Hanaa ; Hardy, John. / Studies on the oxidative polymerization of homogentisic acid to form pyomelanin. Poster session presented at Science Week 2021.

Bibtex

@conference{ba65c14be826439885ea0f5cb2a3e88c,
title = "Studies on the oxidative polymerization of homogentisic acid to form pyomelanin.",
abstract = "The accumulation of homogentisic acid (HGA) in patients with alkaptonuria is associated with the concomitant deposition of pigments contain significant amounts of polymerised HGA (polyHGA) in the bodily tissues of the patients. The polymerisation of HGA under various different conditions in vitro was investigated to attempt to understand if there is a correlation between the conditions and rate of pigment deposition in vivo. In this study, we applied a selection of different analytical chemistry techniques including: nuclear magnetic resonance spectroscopy (NMR), high-performance liquid chromatography (HPLC), gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX), UV-visible spectroscopy (UV-visible) and electron paramagnetic resonance (EPR). We observed condition-dependent polyHGA formation, and are currently correlating these findings with literature data (e.g. histological studies) to understand polyHGA pigment deposition inside specific tissues in the body.",
author = "Hanaa Galeb and John Hardy",
year = "2021",
month = apr,
day = "16",
language = "English",
note = "Science Week 2021 ; Conference date: 12-04-2021 Through 16-04-2021",

}

RIS

TY - CONF

T1 - Studies on the oxidative polymerization of homogentisic acid to form pyomelanin.

AU - Galeb, Hanaa

AU - Hardy, John

PY - 2021/4/16

Y1 - 2021/4/16

N2 - The accumulation of homogentisic acid (HGA) in patients with alkaptonuria is associated with the concomitant deposition of pigments contain significant amounts of polymerised HGA (polyHGA) in the bodily tissues of the patients. The polymerisation of HGA under various different conditions in vitro was investigated to attempt to understand if there is a correlation between the conditions and rate of pigment deposition in vivo. In this study, we applied a selection of different analytical chemistry techniques including: nuclear magnetic resonance spectroscopy (NMR), high-performance liquid chromatography (HPLC), gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX), UV-visible spectroscopy (UV-visible) and electron paramagnetic resonance (EPR). We observed condition-dependent polyHGA formation, and are currently correlating these findings with literature data (e.g. histological studies) to understand polyHGA pigment deposition inside specific tissues in the body.

AB - The accumulation of homogentisic acid (HGA) in patients with alkaptonuria is associated with the concomitant deposition of pigments contain significant amounts of polymerised HGA (polyHGA) in the bodily tissues of the patients. The polymerisation of HGA under various different conditions in vitro was investigated to attempt to understand if there is a correlation between the conditions and rate of pigment deposition in vivo. In this study, we applied a selection of different analytical chemistry techniques including: nuclear magnetic resonance spectroscopy (NMR), high-performance liquid chromatography (HPLC), gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX), UV-visible spectroscopy (UV-visible) and electron paramagnetic resonance (EPR). We observed condition-dependent polyHGA formation, and are currently correlating these findings with literature data (e.g. histological studies) to understand polyHGA pigment deposition inside specific tissues in the body.

M3 - Poster

T2 - Science Week 2021

Y2 - 12 April 2021 through 16 April 2021

ER -