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Substituted dipyridophenazine complexes of Cr(iii): Synthesis, enantiomeric resolution and binding interactions with calf thymus DNA

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Substituted dipyridophenazine complexes of Cr(iii): Synthesis, enantiomeric resolution and binding interactions with calf thymus DNA. / Vasudevan, Suni; Smith, Jayden A.; Wojdyla, Michal et al.
In: Dalton Transactions, Vol. 39, No. 16, 28.04.2010, p. 3990-3998.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Vasudevan, S, Smith, JA, Wojdyla, M, McCabe, T, Fletcher, NC, Quinn, SJ & Kelly, JM 2010, 'Substituted dipyridophenazine complexes of Cr(iii): Synthesis, enantiomeric resolution and binding interactions with calf thymus DNA', Dalton Transactions, vol. 39, no. 16, pp. 3990-3998. https://doi.org/10.1039/c000150c

APA

Vasudevan, S., Smith, J. A., Wojdyla, M., McCabe, T., Fletcher, N. C., Quinn, S. J., & Kelly, J. M. (2010). Substituted dipyridophenazine complexes of Cr(iii): Synthesis, enantiomeric resolution and binding interactions with calf thymus DNA. Dalton Transactions, 39(16), 3990-3998. https://doi.org/10.1039/c000150c

Vancouver

Vasudevan S, Smith JA, Wojdyla M, McCabe T, Fletcher NC, Quinn SJ et al. Substituted dipyridophenazine complexes of Cr(iii): Synthesis, enantiomeric resolution and binding interactions with calf thymus DNA. Dalton Transactions. 2010 Apr 28;39(16):3990-3998. doi: 10.1039/c000150c

Author

Vasudevan, Suni ; Smith, Jayden A. ; Wojdyla, Michal et al. / Substituted dipyridophenazine complexes of Cr(iii) : Synthesis, enantiomeric resolution and binding interactions with calf thymus DNA. In: Dalton Transactions. 2010 ; Vol. 39, No. 16. pp. 3990-3998.

Bibtex

@article{e86080fd6a004ce8b8e45f906347fe83,
title = "Substituted dipyridophenazine complexes of Cr(iii): Synthesis, enantiomeric resolution and binding interactions with calf thymus DNA",
abstract = "[Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent Δ and Λ enantiomers. The DNA-binding interactions of each of the racemic complexes were investigated, with the results of linear dichroism, thermal denaturation, and emission quenching studies indicative of intercalative binding to CT-DNA with a significant electrostatic contribution. UV/Vis absorption titrations suggest strong DNA binding by each of the racemic complexes, with the methylated analogue [Cr(phen)2(Me 2dppz)]3+ exhibiting the largest equilibrium binding constant. Emission quenching and UV-Vis titrations of the enantiomers of [Cr(phen)2(dppz)]3+ imply similar binding affinities for the Δ and Λ isomers, although significant differences between the circular dichroism spectra of the enantiomers in the presence of DNA connote differences in binding orientation and/or conformation between the two.",
author = "Suni Vasudevan and Smith, {Jayden A.} and Michal Wojdyla and Thomas McCabe and Fletcher, {Nicholas C.} and Quinn, {Susan J.} and Kelly, {John M.}",
year = "2010",
month = apr,
day = "28",
doi = "10.1039/c000150c",
language = "English",
volume = "39",
pages = "3990--3998",
journal = "Dalton Transactions",
issn = "1477-9226",
publisher = "Royal Society of Chemistry",
number = "16",

}

RIS

TY - JOUR

T1 - Substituted dipyridophenazine complexes of Cr(iii)

T2 - Synthesis, enantiomeric resolution and binding interactions with calf thymus DNA

AU - Vasudevan, Suni

AU - Smith, Jayden A.

AU - Wojdyla, Michal

AU - McCabe, Thomas

AU - Fletcher, Nicholas C.

AU - Quinn, Susan J.

AU - Kelly, John M.

PY - 2010/4/28

Y1 - 2010/4/28

N2 - [Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent Δ and Λ enantiomers. The DNA-binding interactions of each of the racemic complexes were investigated, with the results of linear dichroism, thermal denaturation, and emission quenching studies indicative of intercalative binding to CT-DNA with a significant electrostatic contribution. UV/Vis absorption titrations suggest strong DNA binding by each of the racemic complexes, with the methylated analogue [Cr(phen)2(Me 2dppz)]3+ exhibiting the largest equilibrium binding constant. Emission quenching and UV-Vis titrations of the enantiomers of [Cr(phen)2(dppz)]3+ imply similar binding affinities for the Δ and Λ isomers, although significant differences between the circular dichroism spectra of the enantiomers in the presence of DNA connote differences in binding orientation and/or conformation between the two.

AB - [Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent Δ and Λ enantiomers. The DNA-binding interactions of each of the racemic complexes were investigated, with the results of linear dichroism, thermal denaturation, and emission quenching studies indicative of intercalative binding to CT-DNA with a significant electrostatic contribution. UV/Vis absorption titrations suggest strong DNA binding by each of the racemic complexes, with the methylated analogue [Cr(phen)2(Me 2dppz)]3+ exhibiting the largest equilibrium binding constant. Emission quenching and UV-Vis titrations of the enantiomers of [Cr(phen)2(dppz)]3+ imply similar binding affinities for the Δ and Λ isomers, although significant differences between the circular dichroism spectra of the enantiomers in the presence of DNA connote differences in binding orientation and/or conformation between the two.

U2 - 10.1039/c000150c

DO - 10.1039/c000150c

M3 - Journal article

AN - SCOPUS:77950478912

VL - 39

SP - 3990

EP - 3998

JO - Dalton Transactions

JF - Dalton Transactions

SN - 1477-9226

IS - 16

ER -