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Supercritical fluid assisted impregnation of indomethacin into chitosan thermosets for controlled release applications

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Supercritical fluid assisted impregnation of indomethacin into chitosan thermosets for controlled release applications. / Gong, K.; Darr, J.A.; Rehman, I.U.

In: International Journal of Pharmaceutics, Vol. 315, No. 1-2, 2006, p. 93-98.

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Gong, K. ; Darr, J.A. ; Rehman, I.U. / Supercritical fluid assisted impregnation of indomethacin into chitosan thermosets for controlled release applications. In: International Journal of Pharmaceutics. 2006 ; Vol. 315, No. 1-2. pp. 93-98.

Bibtex

@article{88eaf2d3273f4f4bb71da33f0fe60031,
title = "Supercritical fluid assisted impregnation of indomethacin into chitosan thermosets for controlled release applications",
abstract = "Supercritical carbon dioxide (sc-CO2) was used to impregnate indomethacin (a non-steroidal anti-inflammatory drug) into chitosan thermosets for the preparation of controlled release formulations. The products were analyzed by a range of methods including powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effects of the experimental temperature and pressure of the sc-CO2 on the thermal behavior of chitosan-indomethacin drug composites (DCs) was investigated via differential scanning calorimeter (DSC). The interaction of chitosan and indomethacin after impregnation was then studied by Fourier transform infrared (FTIR) and Raman spectroscopy, respectively. Our results suggest that the supercritical fluid impregnation process results in indomethacin being amorphously dispersed within the chitosan matrix. FTIR data suggest that the aliphatic carbonyl group of indomethacin interacts with the NH2 group of the chitosan backbone. In vitro dissolution studies (via UV-vis spectroscopy) reveal that the dissolution rate of indomethacin substantially increases after processing in sc-CO2, particularly, under the experimental conditions 20.7 MPa and 70 °C. {\textcopyright} 2006 Elsevier B.V. All rights reserved.",
keywords = "Amorphous, Chitosan, Drug, Impregnation, Indomethacin, sc-CO2, Supercritical fluid, aliphatic compound, amine, carbon dioxide, carbonyl derivative, chitosan, indometacin, nonsteroid antiinflammatory agent, article, controlled drug release, data analysis, differential scanning calorimetry, drug formulation, drug solubility, in vitro study, infrared spectroscopy, pressure, priority journal, scanning electron microscopy, supercritical fluid, temperature, ultraviolet spectroscopy, X ray diffraction, Anti-Inflammatory Agents, Non-Steroidal, Carbon Dioxide, Cold, Cold Temperature, Delayed-Action Preparations, Pressure, Spectrum Analysis, Temperature",
author = "K. Gong and J.A. Darr and I.U. Rehman",
year = "2006",
doi = "10.1016/j.ijpharm.2006.02.030",
language = "English",
volume = "315",
pages = "93--98",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Supercritical fluid assisted impregnation of indomethacin into chitosan thermosets for controlled release applications

AU - Gong, K.

AU - Darr, J.A.

AU - Rehman, I.U.

PY - 2006

Y1 - 2006

N2 - Supercritical carbon dioxide (sc-CO2) was used to impregnate indomethacin (a non-steroidal anti-inflammatory drug) into chitosan thermosets for the preparation of controlled release formulations. The products were analyzed by a range of methods including powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effects of the experimental temperature and pressure of the sc-CO2 on the thermal behavior of chitosan-indomethacin drug composites (DCs) was investigated via differential scanning calorimeter (DSC). The interaction of chitosan and indomethacin after impregnation was then studied by Fourier transform infrared (FTIR) and Raman spectroscopy, respectively. Our results suggest that the supercritical fluid impregnation process results in indomethacin being amorphously dispersed within the chitosan matrix. FTIR data suggest that the aliphatic carbonyl group of indomethacin interacts with the NH2 group of the chitosan backbone. In vitro dissolution studies (via UV-vis spectroscopy) reveal that the dissolution rate of indomethacin substantially increases after processing in sc-CO2, particularly, under the experimental conditions 20.7 MPa and 70 °C. © 2006 Elsevier B.V. All rights reserved.

AB - Supercritical carbon dioxide (sc-CO2) was used to impregnate indomethacin (a non-steroidal anti-inflammatory drug) into chitosan thermosets for the preparation of controlled release formulations. The products were analyzed by a range of methods including powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effects of the experimental temperature and pressure of the sc-CO2 on the thermal behavior of chitosan-indomethacin drug composites (DCs) was investigated via differential scanning calorimeter (DSC). The interaction of chitosan and indomethacin after impregnation was then studied by Fourier transform infrared (FTIR) and Raman spectroscopy, respectively. Our results suggest that the supercritical fluid impregnation process results in indomethacin being amorphously dispersed within the chitosan matrix. FTIR data suggest that the aliphatic carbonyl group of indomethacin interacts with the NH2 group of the chitosan backbone. In vitro dissolution studies (via UV-vis spectroscopy) reveal that the dissolution rate of indomethacin substantially increases after processing in sc-CO2, particularly, under the experimental conditions 20.7 MPa and 70 °C. © 2006 Elsevier B.V. All rights reserved.

KW - Amorphous

KW - Chitosan

KW - Drug

KW - Impregnation

KW - Indomethacin

KW - sc-CO2

KW - Supercritical fluid

KW - aliphatic compound

KW - amine

KW - carbon dioxide

KW - carbonyl derivative

KW - chitosan

KW - indometacin

KW - nonsteroid antiinflammatory agent

KW - article

KW - controlled drug release

KW - data analysis

KW - differential scanning calorimetry

KW - drug formulation

KW - drug solubility

KW - in vitro study

KW - infrared spectroscopy

KW - pressure

KW - priority journal

KW - scanning electron microscopy

KW - supercritical fluid

KW - temperature

KW - ultraviolet spectroscopy

KW - X ray diffraction

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Carbon Dioxide

KW - Cold

KW - Cold Temperature

KW - Delayed-Action Preparations

KW - Pressure

KW - Spectrum Analysis

KW - Temperature

U2 - 10.1016/j.ijpharm.2006.02.030

DO - 10.1016/j.ijpharm.2006.02.030

M3 - Journal article

VL - 315

SP - 93

EP - 98

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -