Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Supercritical fluid assisted impregnation of indomethacin into chitosan thermosets for controlled release applications
AU - Gong, K.
AU - Darr, J.A.
AU - Rehman, I.U.
PY - 2006
Y1 - 2006
N2 - Supercritical carbon dioxide (sc-CO2) was used to impregnate indomethacin (a non-steroidal anti-inflammatory drug) into chitosan thermosets for the preparation of controlled release formulations. The products were analyzed by a range of methods including powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effects of the experimental temperature and pressure of the sc-CO2 on the thermal behavior of chitosan-indomethacin drug composites (DCs) was investigated via differential scanning calorimeter (DSC). The interaction of chitosan and indomethacin after impregnation was then studied by Fourier transform infrared (FTIR) and Raman spectroscopy, respectively. Our results suggest that the supercritical fluid impregnation process results in indomethacin being amorphously dispersed within the chitosan matrix. FTIR data suggest that the aliphatic carbonyl group of indomethacin interacts with the NH2 group of the chitosan backbone. In vitro dissolution studies (via UV-vis spectroscopy) reveal that the dissolution rate of indomethacin substantially increases after processing in sc-CO2, particularly, under the experimental conditions 20.7 MPa and 70 °C. © 2006 Elsevier B.V. All rights reserved.
AB - Supercritical carbon dioxide (sc-CO2) was used to impregnate indomethacin (a non-steroidal anti-inflammatory drug) into chitosan thermosets for the preparation of controlled release formulations. The products were analyzed by a range of methods including powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effects of the experimental temperature and pressure of the sc-CO2 on the thermal behavior of chitosan-indomethacin drug composites (DCs) was investigated via differential scanning calorimeter (DSC). The interaction of chitosan and indomethacin after impregnation was then studied by Fourier transform infrared (FTIR) and Raman spectroscopy, respectively. Our results suggest that the supercritical fluid impregnation process results in indomethacin being amorphously dispersed within the chitosan matrix. FTIR data suggest that the aliphatic carbonyl group of indomethacin interacts with the NH2 group of the chitosan backbone. In vitro dissolution studies (via UV-vis spectroscopy) reveal that the dissolution rate of indomethacin substantially increases after processing in sc-CO2, particularly, under the experimental conditions 20.7 MPa and 70 °C. © 2006 Elsevier B.V. All rights reserved.
KW - Amorphous
KW - Chitosan
KW - Drug
KW - Impregnation
KW - Indomethacin
KW - sc-CO2
KW - Supercritical fluid
KW - aliphatic compound
KW - amine
KW - carbon dioxide
KW - carbonyl derivative
KW - chitosan
KW - indometacin
KW - nonsteroid antiinflammatory agent
KW - article
KW - controlled drug release
KW - data analysis
KW - differential scanning calorimetry
KW - drug formulation
KW - drug solubility
KW - in vitro study
KW - infrared spectroscopy
KW - pressure
KW - priority journal
KW - scanning electron microscopy
KW - supercritical fluid
KW - temperature
KW - ultraviolet spectroscopy
KW - X ray diffraction
KW - Anti-Inflammatory Agents, Non-Steroidal
KW - Carbon Dioxide
KW - Cold
KW - Cold Temperature
KW - Delayed-Action Preparations
KW - Pressure
KW - Spectrum Analysis
KW - Temperature
U2 - 10.1016/j.ijpharm.2006.02.030
DO - 10.1016/j.ijpharm.2006.02.030
M3 - Journal article
VL - 315
SP - 93
EP - 98
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -