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  • Kumari 2020 Carbohydrate Polymers review Journal Pre-proof

    Rights statement: This is the author’s version of a work that was accepted for publication in Carbohydrate Polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers, 255, 117487, 2021 DOI: 10.1016/j.carbpol.2020.117487

    Accepted author manuscript, 5.45 MB, PDF document

    Embargo ends: 5/12/21

    Available under license: CC BY-NC-ND: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

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Surface functionalization of chitosan as a coating material for orthopaedic applications: A Comprehensive Review

Research output: Contribution to journalJournal articlepeer-review

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  • Suman Kumari
  • Hanuma Reddy Tiyyagura
  • Yasir Beeran Pottathara
  • Kishor Kumar Sadasivuni
  • Deepalekshmi Ponnamma
  • Timothy Douglas
  • Andre Skirtach
  • M.K. Mohan
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Article number117487
<mark>Journal publication date</mark>1/03/2021
<mark>Journal</mark>Carbohydrate Polymers
Volume255
Number of pages16
Publication StatusPublished
Early online date5/12/20
<mark>Original language</mark>English

Abstract

Metallic implants have dominated the biomedical implant industries for the past century for load-bearing applications, while the polymeric implants have shown great promise for tissue engineering applications. The surface properties of such implants are critical as the interaction of implant surfaces, and the body tissues may lead to unfavourable reactions. Desired implant properties are biocompatibility, corrosion resistance, and antibacterial activity. A polymer coating is an efficient and economical way to produce such surfaces. A lot of research has been carried out on chitosan (CS)-modified metallic and polymer scaffolds in the last decade. Different methods such as electrophoretic deposition, sol-gel methods, dip coating and spin coating, electrospinning, etc. have been utilized to produce CS coatings. However, a systematic review of chitosan coatings on scaffolds focussing on widely employed techniques is lacking. This review surveys literature concerning the current status of orthopaedic applications of CS for the purpose of coatings. In this review, the various preparation methods of coating, and the role of the surface functionalities in determining the efficiency of coatings are discussed. Effect of nanoparticle additions on the polymeric interfaces and in regulating the properties of surface coatings are also investigated in detail.