Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides
AU - Basson, Ashley J.
AU - McLaughlin, Mark G.
PY - 2021/4/9
Y1 - 2021/4/9
N2 - Herein, we report a sustainable, modular, rapid and high-yielding transformation to afford densely functionalized 5-aminooxazoles and thiazoles. The reaction is tolerant to a wide range of functional groups and is typically complete in under 30 min. Furthermore, the described transformation is inherently green in relation to the catalyst and solvent choice as well as producing environmentally benign alcoholic by-products.
AB - Herein, we report a sustainable, modular, rapid and high-yielding transformation to afford densely functionalized 5-aminooxazoles and thiazoles. The reaction is tolerant to a wide range of functional groups and is typically complete in under 30 min. Furthermore, the described transformation is inherently green in relation to the catalyst and solvent choice as well as producing environmentally benign alcoholic by-products.
KW - calcium catalysis
KW - cyclisation
KW - isocyanides
KW - oxazoles
KW - thiazoles
U2 - 10.1002/cssc.202100225
DO - 10.1002/cssc.202100225
M3 - Journal article
VL - 14
SP - 1696
EP - 1699
JO - ChemSusChem
JF - ChemSusChem
SN - 1864-5631
IS - 7
ER -