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Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides

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Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides. / Basson, Ashley J.; McLaughlin, Mark G.
In: ChemSusChem, Vol. 14, No. 7, 09.04.2021, p. 1696-1699.

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Basson AJ, McLaughlin MG. Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides. ChemSusChem. 2021 Apr 9;14(7):1696-1699. Epub 2021 Mar 3. doi: 10.1002/cssc.202100225

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@article{1319ece988d7418fad07ebab7c30b74a,
title = "Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides",
abstract = "Herein, we report a sustainable, modular, rapid and high-yielding transformation to afford densely functionalized 5-aminooxazoles and thiazoles. The reaction is tolerant to a wide range of functional groups and is typically complete in under 30 min. Furthermore, the described transformation is inherently green in relation to the catalyst and solvent choice as well as producing environmentally benign alcoholic by-products.",
keywords = "calcium catalysis, cyclisation, isocyanides, oxazoles, thiazoles",
author = "Basson, {Ashley J.} and McLaughlin, {Mark G.}",
year = "2021",
month = apr,
day = "9",
doi = "10.1002/cssc.202100225",
language = "English",
volume = "14",
pages = "1696--1699",
journal = "ChemSusChem",
issn = "1864-5631",
publisher = "Wiley-VCH Verlag",
number = "7",

}

RIS

TY - JOUR

T1 - Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides

AU - Basson, Ashley J.

AU - McLaughlin, Mark G.

PY - 2021/4/9

Y1 - 2021/4/9

N2 - Herein, we report a sustainable, modular, rapid and high-yielding transformation to afford densely functionalized 5-aminooxazoles and thiazoles. The reaction is tolerant to a wide range of functional groups and is typically complete in under 30 min. Furthermore, the described transformation is inherently green in relation to the catalyst and solvent choice as well as producing environmentally benign alcoholic by-products.

AB - Herein, we report a sustainable, modular, rapid and high-yielding transformation to afford densely functionalized 5-aminooxazoles and thiazoles. The reaction is tolerant to a wide range of functional groups and is typically complete in under 30 min. Furthermore, the described transformation is inherently green in relation to the catalyst and solvent choice as well as producing environmentally benign alcoholic by-products.

KW - calcium catalysis

KW - cyclisation

KW - isocyanides

KW - oxazoles

KW - thiazoles

U2 - 10.1002/cssc.202100225

DO - 10.1002/cssc.202100225

M3 - Journal article

VL - 14

SP - 1696

EP - 1699

JO - ChemSusChem

JF - ChemSusChem

SN - 1864-5631

IS - 7

ER -