TY - JOUR

T1 - Swimming with protists : perception, motility and flagellum assembly.

AU - Ginger, Michael L.

AU - Portman, Neil

AU - McKean, Paul G.

PY - 2008/11

Y1 - 2008/11

N2 - In unicellular and multicellular eukaryotes, fast cell motility and rapid movement of material over cell surfaces are often mediated by ciliary or flagellar beating. The conserved defining structure in most motile cilia and flagella is the '9+2' microtubule axoneme. Our general understanding of flagellum assembly and the regulation of flagellar motility has been led by results from seminal studies of flagellate protozoa and algae. Here we review recent work relating to various aspects of protist physiology and cell biology. In particular, we discuss energy metabolism in eukaryotic flagella, modifications to the canonical assembly pathway and flagellum function in parasite virulence.

AB - In unicellular and multicellular eukaryotes, fast cell motility and rapid movement of material over cell surfaces are often mediated by ciliary or flagellar beating. The conserved defining structure in most motile cilia and flagella is the '9+2' microtubule axoneme. Our general understanding of flagellum assembly and the regulation of flagellar motility has been led by results from seminal studies of flagellate protozoa and algae. Here we review recent work relating to various aspects of protist physiology and cell biology. In particular, we discuss energy metabolism in eukaryotic flagella, modifications to the canonical assembly pathway and flagellum function in parasite virulence.

U2 - 10.1038/nrmicro2009

DO - 10.1038/nrmicro2009

M3 - Journal article

VL - 6

SP - 838

EP - 850

JO - Nature Reviews in Microbiology

JF - Nature Reviews in Microbiology

SN - 1740-1534

IS - 11

ER -