Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Synthesis and characterization of calcium deficient apatite granules for drug eluting bone graft applications
AU - Mir, M.
AU - Anwar Siddiqi, S.
AU - Hussain, T.
AU - Anwar Chaudhry, A.
AU - Ur Rehman, I.
AU - Khan, A.S.
AU - Abbas, G.
PY - 2014
Y1 - 2014
N2 - Antibiotic loaded calcium deficient apatite (CDA) granules were prepared by wet chemical synthesis followed by microwave irradiation. Microporous CDA granules were loaded with three broad spectrum antibiotics (Amoxicillin, Gentamicin and Chloramphenicol). The aim of this study was to evaluate the in-vitro performance of locally released antibiotics which has a potential to treat infected osseous defects. In-vitro studies of the synthesized material elucidated high drug loading capacity and a drug release profile spanning a period of more than 24 h. The respective antibiotic functional groups were analyzed by Fourier Transform Infrared Spectroscopy (FT-IR). X-ray Diffraction (XRD) was used to study the phase purity of synthesized CDA. Drug release profiles were determined by using UV-vis Spectroscopy. Scanning Electron Microscopy (SEM) was used to investigate granule sizes and porosity. Particle size (2-20 μm) with an average pore diameter of 2.9 μm (±0.5 μm) was achieved without heat-treatment and use of any porogens. Thermal stability was determined using simultaneous Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). The drug release profile showed initial burst release followed by sustained release periodically. © 2014 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
AB - Antibiotic loaded calcium deficient apatite (CDA) granules were prepared by wet chemical synthesis followed by microwave irradiation. Microporous CDA granules were loaded with three broad spectrum antibiotics (Amoxicillin, Gentamicin and Chloramphenicol). The aim of this study was to evaluate the in-vitro performance of locally released antibiotics which has a potential to treat infected osseous defects. In-vitro studies of the synthesized material elucidated high drug loading capacity and a drug release profile spanning a period of more than 24 h. The respective antibiotic functional groups were analyzed by Fourier Transform Infrared Spectroscopy (FT-IR). X-ray Diffraction (XRD) was used to study the phase purity of synthesized CDA. Drug release profiles were determined by using UV-vis Spectroscopy. Scanning Electron Microscopy (SEM) was used to investigate granule sizes and porosity. Particle size (2-20 μm) with an average pore diameter of 2.9 μm (±0.5 μm) was achieved without heat-treatment and use of any porogens. Thermal stability was determined using simultaneous Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). The drug release profile showed initial burst release followed by sustained release periodically. © 2014 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
KW - Calcium deficient apatite
KW - Local antibiotic therapy
KW - Microporous granules
KW - Antibiotics
KW - Apatite
KW - Calcium
KW - Differential scanning calorimetry
KW - Fourier transform infrared spectroscopy
KW - Functional groups
KW - Microporosity
KW - Scanning electron microscopy
KW - Thermogravimetric analysis
KW - Ultraviolet visible spectroscopy
KW - X ray diffraction
KW - Antibiotic therapy
KW - Broad spectrum antibiotics
KW - Calcium deficient apatites
KW - Fourier transform infra red (FTIR) spectroscopy
KW - Microporous
KW - Synthesis and characterizations
KW - Synthesized materials
KW - Wet chemical synthesis
KW - Granulation
U2 - 10.1016/j.ceramint.2014.03.059
DO - 10.1016/j.ceramint.2014.03.059
M3 - Journal article
VL - 40
SP - 10719
EP - 10725
JO - Ceramics International
JF - Ceramics International
SN - 0272-8842
IS - 7 Part B
ER -