Synthesis and characterization of grafted nanohydroxyapatites using functionalized surface agents

School of Engineering

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https://doi.org/10.1021/la063517i
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Synthesis and characterization of grafted nanohydroxyapatites using functionalized surface agents. / Haque, S.; Rehman, I.; Darr, J.A.
In: Langmuir, Vol. 23, No. 12, 2007, p. 6671-6676.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{ec318a9b889b4a24aebf5cc8c3633642,

title = "Synthesis and characterization of grafted nanohydroxyapatites using functionalized surface agents",

abstract = "Synthetic hydroxyapatite, HA [Ca10(PO4) 6(OH)2], is a bioactive material that is chemically similar to biological apatite, the mineral phase of bone (a nanocomposite material). Synthetic biocomposites, comprising a polymer and hydroxyapatite that are used for bone replacement, have limitations when loaded under fatigue in that the weak mechanical bond between the two phases can result in failure at the interface. Chemical coupling of the HA and polymer matrix may provide a means of improving the interfacial bonding between the polymer and HA phases. Herein, we report our first steps toward developing chemically coupled nano-biocomposites via a two-step process. We describe the synthesis and characterization of surface-grafted hydroxyapatite (SG-HA), which possesses a reactive C=C functional group. In future work, we will report on the second step, namely the coupling of this functional group to a polymer by a copolymerization reaction to give a chemically coupled nano-biocomposite. The SG-HA reported herein was characterized by a range of methods including 31P and 13C magic-angle spinning (MAS)-NMR, Fourier transform infrared (FTIR), and Raman spectroscopy. {\textcopyright} 2007 American Chemical Society.",

keywords = "Biocomposites, Surface agents, Bone, Chemical bonds, Copolymerization, Grafting (chemical), Interfaces (materials), Synthesis (chemical), Hydroxyapatite, carboxylic acid, hydroxyapatite, nanocomposite, article, chemistry, infrared spectroscopy, mass spectrometry, particle size, surface property, synthesis, ultrastructure, Acids, Acyclic, Durapatite, Mass Spectrometry, Nanocomposites, Particle Size, Spectroscopy, Fourier Transform Infrared, Surface Properties",

author = "S. Haque and I. Rehman and J.A. Darr",

year = "2007",

doi = "10.1021/la063517i",

language = "English",

volume = "23",

pages = "6671--6676",

journal = "Langmuir",

issn = "0743-7463",

publisher = "AMER CHEMICAL SOC",

number = "12",

}

RIS

TY - JOUR

T1 - Synthesis and characterization of grafted nanohydroxyapatites using functionalized surface agents

AU - Haque, S.

AU - Rehman, I.

AU - Darr, J.A.

PY - 2007

Y1 - 2007

N2 - Synthetic hydroxyapatite, HA [Ca10(PO4) 6(OH)2], is a bioactive material that is chemically similar to biological apatite, the mineral phase of bone (a nanocomposite material). Synthetic biocomposites, comprising a polymer and hydroxyapatite that are used for bone replacement, have limitations when loaded under fatigue in that the weak mechanical bond between the two phases can result in failure at the interface. Chemical coupling of the HA and polymer matrix may provide a means of improving the interfacial bonding between the polymer and HA phases. Herein, we report our first steps toward developing chemically coupled nano-biocomposites via a two-step process. We describe the synthesis and characterization of surface-grafted hydroxyapatite (SG-HA), which possesses a reactive C=C functional group. In future work, we will report on the second step, namely the coupling of this functional group to a polymer by a copolymerization reaction to give a chemically coupled nano-biocomposite. The SG-HA reported herein was characterized by a range of methods including 31P and 13C magic-angle spinning (MAS)-NMR, Fourier transform infrared (FTIR), and Raman spectroscopy. © 2007 American Chemical Society.

AB - Synthetic hydroxyapatite, HA [Ca10(PO4) 6(OH)2], is a bioactive material that is chemically similar to biological apatite, the mineral phase of bone (a nanocomposite material). Synthetic biocomposites, comprising a polymer and hydroxyapatite that are used for bone replacement, have limitations when loaded under fatigue in that the weak mechanical bond between the two phases can result in failure at the interface. Chemical coupling of the HA and polymer matrix may provide a means of improving the interfacial bonding between the polymer and HA phases. Herein, we report our first steps toward developing chemically coupled nano-biocomposites via a two-step process. We describe the synthesis and characterization of surface-grafted hydroxyapatite (SG-HA), which possesses a reactive C=C functional group. In future work, we will report on the second step, namely the coupling of this functional group to a polymer by a copolymerization reaction to give a chemically coupled nano-biocomposite. The SG-HA reported herein was characterized by a range of methods including 31P and 13C magic-angle spinning (MAS)-NMR, Fourier transform infrared (FTIR), and Raman spectroscopy. © 2007 American Chemical Society.

KW - Biocomposites

KW - Surface agents

KW - Bone

KW - Chemical bonds

KW - Copolymerization

KW - Grafting (chemical)

KW - Interfaces (materials)

KW - Synthesis (chemical)

KW - Hydroxyapatite

KW - carboxylic acid

KW - hydroxyapatite

KW - nanocomposite

KW - article

KW - chemistry

KW - infrared spectroscopy

KW - mass spectrometry

KW - particle size

KW - surface property

KW - synthesis

KW - ultrastructure

KW - Acids, Acyclic

KW - Durapatite

KW - Mass Spectrometry

KW - Nanocomposites

KW - Particle Size

KW - Spectroscopy, Fourier Transform Infrared

KW - Surface Properties

U2 - 10.1021/la063517i

DO - 10.1021/la063517i

M3 - Journal article

VL - 23

SP - 6671

EP - 6676

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 12

ER -

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