Research output: Contribution to Journal/Magazine › Journal article › peer-review
Synthesis and characterization of grafted nanohydroxyapatites using functionalized surface agents. / Haque, S.; Rehman, I.; Darr, J.A.
In: Langmuir, Vol. 23, No. 12, 2007, p. 6671-6676.Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Synthesis and characterization of grafted nanohydroxyapatites using functionalized surface agents
AU - Haque, S.
AU - Rehman, I.
AU - Darr, J.A.
PY - 2007
Y1 - 2007
N2 - Synthetic hydroxyapatite, HA [Ca10(PO4) 6(OH)2], is a bioactive material that is chemically similar to biological apatite, the mineral phase of bone (a nanocomposite material). Synthetic biocomposites, comprising a polymer and hydroxyapatite that are used for bone replacement, have limitations when loaded under fatigue in that the weak mechanical bond between the two phases can result in failure at the interface. Chemical coupling of the HA and polymer matrix may provide a means of improving the interfacial bonding between the polymer and HA phases. Herein, we report our first steps toward developing chemically coupled nano-biocomposites via a two-step process. We describe the synthesis and characterization of surface-grafted hydroxyapatite (SG-HA), which possesses a reactive C=C functional group. In future work, we will report on the second step, namely the coupling of this functional group to a polymer by a copolymerization reaction to give a chemically coupled nano-biocomposite. The SG-HA reported herein was characterized by a range of methods including 31P and 13C magic-angle spinning (MAS)-NMR, Fourier transform infrared (FTIR), and Raman spectroscopy. © 2007 American Chemical Society.
AB - Synthetic hydroxyapatite, HA [Ca10(PO4) 6(OH)2], is a bioactive material that is chemically similar to biological apatite, the mineral phase of bone (a nanocomposite material). Synthetic biocomposites, comprising a polymer and hydroxyapatite that are used for bone replacement, have limitations when loaded under fatigue in that the weak mechanical bond between the two phases can result in failure at the interface. Chemical coupling of the HA and polymer matrix may provide a means of improving the interfacial bonding between the polymer and HA phases. Herein, we report our first steps toward developing chemically coupled nano-biocomposites via a two-step process. We describe the synthesis and characterization of surface-grafted hydroxyapatite (SG-HA), which possesses a reactive C=C functional group. In future work, we will report on the second step, namely the coupling of this functional group to a polymer by a copolymerization reaction to give a chemically coupled nano-biocomposite. The SG-HA reported herein was characterized by a range of methods including 31P and 13C magic-angle spinning (MAS)-NMR, Fourier transform infrared (FTIR), and Raman spectroscopy. © 2007 American Chemical Society.
KW - Biocomposites
KW - Surface agents
KW - Bone
KW - Chemical bonds
KW - Copolymerization
KW - Grafting (chemical)
KW - Interfaces (materials)
KW - Synthesis (chemical)
KW - Hydroxyapatite
KW - carboxylic acid
KW - hydroxyapatite
KW - nanocomposite
KW - article
KW - chemistry
KW - infrared spectroscopy
KW - mass spectrometry
KW - particle size
KW - surface property
KW - synthesis
KW - ultrastructure
KW - Acids, Acyclic
KW - Durapatite
KW - Mass Spectrometry
KW - Nanocomposites
KW - Particle Size
KW - Spectroscopy, Fourier Transform Infrared
KW - Surface Properties
U2 - 10.1021/la063517i
DO - 10.1021/la063517i
M3 - Journal article
VL - 23
SP - 6671
EP - 6676
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 12
ER -