Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Synthesis and characterization of nano-biomaterials with potential osteological applications
AU - Phillips, M.J.
AU - Darr, J.A.
AU - Luklinska, Z.B.
AU - Rehman, I.
PY - 2003
Y1 - 2003
N2 - The manufacture of high-surface area, un-agglomerated nano-sized (1-100 nm) bioceramic particles are of interest for many applications including injectable/controlled setting bone cements, high strength porous/non-porous synthetic bone grafts, and the reinforcing phase in nano-composites that attempt to mimic the complex structure and superior mechanical properties of bone. In the present study, we report on the manufacture of nano-particle hydroxyapatite powders by several wet chemical methods, which incorporate a freeze-drying step. In particular, it was found that the emulsion-based syntheses yielded powders with high surface areas and small primary particle sizes. Freeze drying rather than oven drying of powders prepared by conventional wet chemical synthesis yielded a nano-sized powder with a comparatively higher surface area of 113m2/g. All powders were calcined in air in a furnace at 900°C investigate the effects of synthesis method on phase purity and surface area. The materials were characterized by a range of analytical methods including Fourier-transform infrared spectroscopy employing the photo acoustic (PAS-FTIR) sampling technique, BET surface area analysis, X-ray powder diffraction (XRD), and the particles were examined using a transmission electron microscope (TEM). © 2003 Kluwer Academic Publishers.
AB - The manufacture of high-surface area, un-agglomerated nano-sized (1-100 nm) bioceramic particles are of interest for many applications including injectable/controlled setting bone cements, high strength porous/non-porous synthetic bone grafts, and the reinforcing phase in nano-composites that attempt to mimic the complex structure and superior mechanical properties of bone. In the present study, we report on the manufacture of nano-particle hydroxyapatite powders by several wet chemical methods, which incorporate a freeze-drying step. In particular, it was found that the emulsion-based syntheses yielded powders with high surface areas and small primary particle sizes. Freeze drying rather than oven drying of powders prepared by conventional wet chemical synthesis yielded a nano-sized powder with a comparatively higher surface area of 113m2/g. All powders were calcined in air in a furnace at 900°C investigate the effects of synthesis method on phase purity and surface area. The materials were characterized by a range of analytical methods including Fourier-transform infrared spectroscopy employing the photo acoustic (PAS-FTIR) sampling technique, BET surface area analysis, X-ray powder diffraction (XRD), and the particles were examined using a transmission electron microscope (TEM). © 2003 Kluwer Academic Publishers.
KW - Emulsions
KW - Fourier transform infrared spectroscopy
KW - Grafts
KW - Hydroxyapatite
KW - Nanostructured materials
KW - Particle size analysis
KW - Structure (composition)
KW - Surface phenomena
KW - Synthesis (chemical)
KW - Transmission electron microscopy
KW - X ray diffraction analysis
KW - Phase purity
KW - Bone cement
KW - biomaterial
KW - hydroxyapatite
KW - nanoparticle
KW - air
KW - analytic method
KW - article
KW - bone
KW - chemical analysis
KW - chemical procedures
KW - device
KW - emulsion
KW - freeze drying
KW - furnace
KW - infrared spectroscopy
KW - powder
KW - priority journal
KW - sampling
KW - surface property
KW - synthesis
KW - temperature
KW - transmission electron microscopy
KW - X ray diffraction
U2 - 10.1023/A:1025682626383
DO - 10.1023/A:1025682626383
M3 - Journal article
VL - 14
SP - 875
EP - 882
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 10
ER -