Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Synthesis and in-vitro analysis of degradative resistance of a novel bioactive composite
AU - Khan, A.S.
AU - Aziz, M.S.
AU - Paul, D.
AU - Wong, F.
AU - Rehman, I.U.
PY - 2008
Y1 - 2008
N2 - The biostability of the polymer is one of the critical parameters to use them for biomaterial application. Polyurethane being one of the most compliant polymer but there are concerns regarding its resistance to degradation, particularly from hydrolysis and oxidation. The aim of this study is to synthesise a novel bioactive composite by creating a covalent linkage between polyurethane and nano-apatites and to analyse the in-vitro hydrolytic degradation of a series of newly synthesised polyurethane (PU) and polyurethane/nano-hydroxyapatite (PU/n-HA) composites. Nano-apatite powder was produced through sol-gel technique. A novel polyurethane composite material was prepared by chemically bonding the n-HA to the diisocyanate component in the polyurethane backbone by utilising solvent polymerisation. The concentration of nano-apatite was 5, 10, 15 and 20% wt/wt in polyurethane. Hydrolytic degradation of the PU and PU/n-HA composites were carried out both in deionised water and in phosphate buffer solution (PBS) having (pH 7.4) at 37 °C for a predetermined time interval of 90 days. The PU and PU/ n-HA composites were physically and chemically characterised by using contact angle measurement, weight loss, Fourier Transform Infrared spectroscopy couples with Photoacoustic Sampling Cell (FTIR-PAS), Raman Spectroscopy, X-ray Diffraction (XRD) and Scanning electron microscopy (SEM). These characterisations showed that with the addition of n-HA the composite exhibits hydrophobic behaviour and degradation rate reduces due to covalent linkage between n-HA and PU. Hence it has been concluded that the degradation rate of the newly developed PU/n-HA composites can be controlled, which helps in tailor making the biomaterial for specific applications. Copyright © 2008 American Scientific Publishers All rights reserved.
AB - The biostability of the polymer is one of the critical parameters to use them for biomaterial application. Polyurethane being one of the most compliant polymer but there are concerns regarding its resistance to degradation, particularly from hydrolysis and oxidation. The aim of this study is to synthesise a novel bioactive composite by creating a covalent linkage between polyurethane and nano-apatites and to analyse the in-vitro hydrolytic degradation of a series of newly synthesised polyurethane (PU) and polyurethane/nano-hydroxyapatite (PU/n-HA) composites. Nano-apatite powder was produced through sol-gel technique. A novel polyurethane composite material was prepared by chemically bonding the n-HA to the diisocyanate component in the polyurethane backbone by utilising solvent polymerisation. The concentration of nano-apatite was 5, 10, 15 and 20% wt/wt in polyurethane. Hydrolytic degradation of the PU and PU/n-HA composites were carried out both in deionised water and in phosphate buffer solution (PBS) having (pH 7.4) at 37 °C for a predetermined time interval of 90 days. The PU and PU/ n-HA composites were physically and chemically characterised by using contact angle measurement, weight loss, Fourier Transform Infrared spectroscopy couples with Photoacoustic Sampling Cell (FTIR-PAS), Raman Spectroscopy, X-ray Diffraction (XRD) and Scanning electron microscopy (SEM). These characterisations showed that with the addition of n-HA the composite exhibits hydrophobic behaviour and degradation rate reduces due to covalent linkage between n-HA and PU. Hence it has been concluded that the degradation rate of the newly developed PU/n-HA composites can be controlled, which helps in tailor making the biomaterial for specific applications. Copyright © 2008 American Scientific Publishers All rights reserved.
KW - Bioactive nano-composites
KW - Degradation
KW - FTIR
KW - Hydroxyapatite
KW - Polyurethanes
KW - Raman spectroscopy
KW - Angle measurement
KW - Apatite
KW - Biological membranes
KW - Biomaterials
KW - Composite materials
KW - Composite micromechanics
KW - Contact angle
KW - Deionized water
KW - Fourier transform infrared spectroscopy
KW - Fourier transforms
KW - Gelation
KW - Hydroxylation
KW - Nanocomposites
KW - Phosphate minerals
KW - Photoacoustic spectroscopy
KW - Photodegradation
KW - Polymers
KW - Raman scattering
KW - Scanning electron microscopy
KW - Spectroscopic analysis
KW - Spectrum analysis
KW - Bioactive composites
KW - Biomaterial applications
KW - Biostability
KW - Concentration of
KW - Contact-angle measurements
KW - Covalent linkages
KW - Critical parameters
KW - Degradation rates
KW - Diisocyanate
KW - Fourier transform infra-red spectroscopies
KW - Ftir salp
KW - Hydrolytic degradations
KW - In-vitro
KW - In-vitro analysis
KW - Nano apatites
KW - Phosphate buffer solutions
KW - Polymerisation
KW - Polyurethane composites
KW - Sampling cells
KW - Sem
KW - Sol-gel techniques
KW - Time intervals
KW - Weight loss
KW - X-ray diffractions
U2 - 10.1166/jbns.2008.033
DO - 10.1166/jbns.2008.033
M3 - Journal article
VL - 2
SP - 75
EP - 88
JO - Journal of Bionanoscience
JF - Journal of Bionanoscience
SN - 1557-7910
IS - 2
ER -