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Synthesis of bufalin derivatives with inhibitory activity against prostate cancer cells

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Synthesis of bufalin derivatives with inhibitory activity against prostate cancer cells. / Yuan, Xiao-Feng; Tian, Hai-Yan; Li, Juan; Jin, Lu; Jiang, Shu-Tai; Liu, Ken Wing-Keung; Luo, Cheng; Middleton, David A.; Esmann, Mikael; Ye, Wen-Cai; Jiang, Ren-Wang.

In: Natural Product Research, Vol. 28, No. 11, 03.06.2014, p. 843-847.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Yuan, X-F, Tian, H-Y, Li, J, Jin, L, Jiang, S-T, Liu, KW-K, Luo, C, Middleton, DA, Esmann, M, Ye, W-C & Jiang, R-W 2014, 'Synthesis of bufalin derivatives with inhibitory activity against prostate cancer cells', Natural Product Research, vol. 28, no. 11, pp. 843-847. https://doi.org/10.1080/14786419.2014.881363

APA

Yuan, X-F., Tian, H-Y., Li, J., Jin, L., Jiang, S-T., Liu, K. W-K., Luo, C., Middleton, D. A., Esmann, M., Ye, W-C., & Jiang, R-W. (2014). Synthesis of bufalin derivatives with inhibitory activity against prostate cancer cells. Natural Product Research, 28(11), 843-847. https://doi.org/10.1080/14786419.2014.881363

Vancouver

Yuan X-F, Tian H-Y, Li J, Jin L, Jiang S-T, Liu KW-K et al. Synthesis of bufalin derivatives with inhibitory activity against prostate cancer cells. Natural Product Research. 2014 Jun 3;28(11):843-847. https://doi.org/10.1080/14786419.2014.881363

Author

Yuan, Xiao-Feng ; Tian, Hai-Yan ; Li, Juan ; Jin, Lu ; Jiang, Shu-Tai ; Liu, Ken Wing-Keung ; Luo, Cheng ; Middleton, David A. ; Esmann, Mikael ; Ye, Wen-Cai ; Jiang, Ren-Wang. / Synthesis of bufalin derivatives with inhibitory activity against prostate cancer cells. In: Natural Product Research. 2014 ; Vol. 28, No. 11. pp. 843-847.

Bibtex

@article{5240bb515a1f4799af9ff7672c0e93b0,
title = "Synthesis of bufalin derivatives with inhibitory activity against prostate cancer cells",
abstract = "Bufalin possesses a strong anti-cancer effect, but the cardiac toxicity targeting the Na+, K+-ATPase limits its application. Here, two bufalin derivatives, bufadienolactam (1) and secobufalinamide (2), were synthesised by treating bufalin with ammonium acetate in dimethylformamide solution. Their structures were elucidated by extensive spectroscopic methods. The structure of compound 2 was further confirmed by single-crystal X-ray diffraction analysis. Compounds 1 and 2 expressed strong inhibitory activities against androgen-dependent prostate cancer cells (IC50 values about 10 mu M), but only weak inhibition on Na+, K+-ATPase (K-i about 70 mu M), indicating that they might be potential anti-prostate cancer agents without severe cardiac toxicity.",
keywords = "bufalin, prostate cancer, Na+, K+-ATPase, androgen receptor, ANDROGEN-RECEPTOR-ANTAGONIST, THERAPY",
author = "Xiao-Feng Yuan and Hai-Yan Tian and Juan Li and Lu Jin and Shu-Tai Jiang and Liu, {Ken Wing-Keung} and Cheng Luo and Middleton, {David A.} and Mikael Esmann and Wen-Cai Ye and Ren-Wang Jiang",
year = "2014",
month = jun,
day = "3",
doi = "10.1080/14786419.2014.881363",
language = "English",
volume = "28",
pages = "843--847",
journal = "Natural Product Research",
issn = "1478-6419",
publisher = "Taylor and Francis Ltd.",
number = "11",

}

RIS

TY - JOUR

T1 - Synthesis of bufalin derivatives with inhibitory activity against prostate cancer cells

AU - Yuan, Xiao-Feng

AU - Tian, Hai-Yan

AU - Li, Juan

AU - Jin, Lu

AU - Jiang, Shu-Tai

AU - Liu, Ken Wing-Keung

AU - Luo, Cheng

AU - Middleton, David A.

AU - Esmann, Mikael

AU - Ye, Wen-Cai

AU - Jiang, Ren-Wang

PY - 2014/6/3

Y1 - 2014/6/3

N2 - Bufalin possesses a strong anti-cancer effect, but the cardiac toxicity targeting the Na+, K+-ATPase limits its application. Here, two bufalin derivatives, bufadienolactam (1) and secobufalinamide (2), were synthesised by treating bufalin with ammonium acetate in dimethylformamide solution. Their structures were elucidated by extensive spectroscopic methods. The structure of compound 2 was further confirmed by single-crystal X-ray diffraction analysis. Compounds 1 and 2 expressed strong inhibitory activities against androgen-dependent prostate cancer cells (IC50 values about 10 mu M), but only weak inhibition on Na+, K+-ATPase (K-i about 70 mu M), indicating that they might be potential anti-prostate cancer agents without severe cardiac toxicity.

AB - Bufalin possesses a strong anti-cancer effect, but the cardiac toxicity targeting the Na+, K+-ATPase limits its application. Here, two bufalin derivatives, bufadienolactam (1) and secobufalinamide (2), were synthesised by treating bufalin with ammonium acetate in dimethylformamide solution. Their structures were elucidated by extensive spectroscopic methods. The structure of compound 2 was further confirmed by single-crystal X-ray diffraction analysis. Compounds 1 and 2 expressed strong inhibitory activities against androgen-dependent prostate cancer cells (IC50 values about 10 mu M), but only weak inhibition on Na+, K+-ATPase (K-i about 70 mu M), indicating that they might be potential anti-prostate cancer agents without severe cardiac toxicity.

KW - bufalin

KW - prostate cancer

KW - Na+

KW - K+-ATPase

KW - androgen receptor

KW - ANDROGEN-RECEPTOR-ANTAGONIST

KW - THERAPY

U2 - 10.1080/14786419.2014.881363

DO - 10.1080/14786419.2014.881363

M3 - Journal article

VL - 28

SP - 843

EP - 847

JO - Natural Product Research

JF - Natural Product Research

SN - 1478-6419

IS - 11

ER -