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Synthesis of pH-sensitive ternary hydrogel with synergetic antibacterial response for the release of ampicillin sodium

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Synthesis of pH-sensitive ternary hydrogel with synergetic antibacterial response for the release of ampicillin sodium. / Andlib, Huma; Shafiq, Muhammad; Sabir, Aneela et al.
In: Journal of Drug Delivery Science and Technology, Vol. 104, 106462, 28.02.2025.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Andlib H, Shafiq M, Sabir A, Jabeen S, Douglas T. Synthesis of pH-sensitive ternary hydrogel with synergetic antibacterial response for the release of ampicillin sodium. Journal of Drug Delivery Science and Technology. 2025 Feb 28;104:106462. Epub 2024 Dec 4. doi: 10.1016/j.jddst.2024.106462

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Andlib, Huma ; Shafiq, Muhammad ; Sabir, Aneela et al. / Synthesis of pH-sensitive ternary hydrogel with synergetic antibacterial response for the release of ampicillin sodium. In: Journal of Drug Delivery Science and Technology. 2025 ; Vol. 104.

Bibtex

@article{9bd0a52e14a24e6d8194773f9ffc9edf,
title = "Synthesis of pH-sensitive ternary hydrogel with synergetic antibacterial response for the release of ampicillin sodium",
abstract = "In the area of biomedicine, pH-responsive hydrogels have attracted a lot of attention. The smart novel polyelectrolyte complex carriers are made of chitosan, gum arabic and polyvinylpyrrolidone using various concentrations of ratan-jot plant extract for the release of sodium ampicillin antibiotic very first time. These hydrogels have been prepared by solution casting method and cross-linked by using 3-aminopropyldiethoxymethyl silane. According to swelling experiments, the cross linker concentration led to decreased swelling because the hydrogels were more tightly packed together.CPG-3A showed maximum swelling 54.5g/g in 210 minutes. When the swelling behaviour of hydrogels was tested under various pH circumstances, it was found that they swelled most noticeably in alkaline media and least noticeably in acidic and neutral pH settings. These hydrogels may be appropriate for injection-based controlled drug release due to their unique pH-responsive behaviour. Ampicillin sodium salt was utilised as a model drug to analyse drug release behaviour of engineered hydrogel at pH 7.4. The results indicate that these smart hydrogels could be used for injectable controlled drug release (ampicillin sodium) for the treatment of wound as well as for other biomedical applications.",
author = "Huma Andlib and Muhammad Shafiq and Aneela Sabir and Sehrish Jabeen and Timothy Douglas",
year = "2025",
month = feb,
day = "28",
doi = "10.1016/j.jddst.2024.106462",
language = "English",
volume = "104",
journal = "Journal of Drug Delivery Science and Technology",
issn = "1773-2247",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Synthesis of pH-sensitive ternary hydrogel with synergetic antibacterial response for the release of ampicillin sodium

AU - Andlib, Huma

AU - Shafiq, Muhammad

AU - Sabir, Aneela

AU - Jabeen, Sehrish

AU - Douglas, Timothy

PY - 2025/2/28

Y1 - 2025/2/28

N2 - In the area of biomedicine, pH-responsive hydrogels have attracted a lot of attention. The smart novel polyelectrolyte complex carriers are made of chitosan, gum arabic and polyvinylpyrrolidone using various concentrations of ratan-jot plant extract for the release of sodium ampicillin antibiotic very first time. These hydrogels have been prepared by solution casting method and cross-linked by using 3-aminopropyldiethoxymethyl silane. According to swelling experiments, the cross linker concentration led to decreased swelling because the hydrogels were more tightly packed together.CPG-3A showed maximum swelling 54.5g/g in 210 minutes. When the swelling behaviour of hydrogels was tested under various pH circumstances, it was found that they swelled most noticeably in alkaline media and least noticeably in acidic and neutral pH settings. These hydrogels may be appropriate for injection-based controlled drug release due to their unique pH-responsive behaviour. Ampicillin sodium salt was utilised as a model drug to analyse drug release behaviour of engineered hydrogel at pH 7.4. The results indicate that these smart hydrogels could be used for injectable controlled drug release (ampicillin sodium) for the treatment of wound as well as for other biomedical applications.

AB - In the area of biomedicine, pH-responsive hydrogels have attracted a lot of attention. The smart novel polyelectrolyte complex carriers are made of chitosan, gum arabic and polyvinylpyrrolidone using various concentrations of ratan-jot plant extract for the release of sodium ampicillin antibiotic very first time. These hydrogels have been prepared by solution casting method and cross-linked by using 3-aminopropyldiethoxymethyl silane. According to swelling experiments, the cross linker concentration led to decreased swelling because the hydrogels were more tightly packed together.CPG-3A showed maximum swelling 54.5g/g in 210 minutes. When the swelling behaviour of hydrogels was tested under various pH circumstances, it was found that they swelled most noticeably in alkaline media and least noticeably in acidic and neutral pH settings. These hydrogels may be appropriate for injection-based controlled drug release due to their unique pH-responsive behaviour. Ampicillin sodium salt was utilised as a model drug to analyse drug release behaviour of engineered hydrogel at pH 7.4. The results indicate that these smart hydrogels could be used for injectable controlled drug release (ampicillin sodium) for the treatment of wound as well as for other biomedical applications.

U2 - 10.1016/j.jddst.2024.106462

DO - 10.1016/j.jddst.2024.106462

M3 - Journal article

VL - 104

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

M1 - 106462

ER -