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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Synthesis of pH-sensitive ternary hydrogel with synergetic antibacterial response for the release of ampicillin sodium
AU - Andlib, Huma
AU - Shafiq, Muhammad
AU - Sabir, Aneela
AU - Jabeen, Sehrish
AU - Douglas, Timothy
PY - 2025/2/28
Y1 - 2025/2/28
N2 - In the area of biomedicine, pH-responsive hydrogels have attracted a lot of attention. The smart novel polyelectrolyte complex carriers are made of chitosan, gum arabic and polyvinylpyrrolidone using various concentrations of ratan-jot plant extract for the release of sodium ampicillin antibiotic very first time. These hydrogels have been prepared by solution casting method and cross-linked by using 3-aminopropyldiethoxymethyl silane. According to swelling experiments, the cross linker concentration led to decreased swelling because the hydrogels were more tightly packed together.CPG-3A showed maximum swelling 54.5g/g in 210 minutes. When the swelling behaviour of hydrogels was tested under various pH circumstances, it was found that they swelled most noticeably in alkaline media and least noticeably in acidic and neutral pH settings. These hydrogels may be appropriate for injection-based controlled drug release due to their unique pH-responsive behaviour. Ampicillin sodium salt was utilised as a model drug to analyse drug release behaviour of engineered hydrogel at pH 7.4. The results indicate that these smart hydrogels could be used for injectable controlled drug release (ampicillin sodium) for the treatment of wound as well as for other biomedical applications.
AB - In the area of biomedicine, pH-responsive hydrogels have attracted a lot of attention. The smart novel polyelectrolyte complex carriers are made of chitosan, gum arabic and polyvinylpyrrolidone using various concentrations of ratan-jot plant extract for the release of sodium ampicillin antibiotic very first time. These hydrogels have been prepared by solution casting method and cross-linked by using 3-aminopropyldiethoxymethyl silane. According to swelling experiments, the cross linker concentration led to decreased swelling because the hydrogels were more tightly packed together.CPG-3A showed maximum swelling 54.5g/g in 210 minutes. When the swelling behaviour of hydrogels was tested under various pH circumstances, it was found that they swelled most noticeably in alkaline media and least noticeably in acidic and neutral pH settings. These hydrogels may be appropriate for injection-based controlled drug release due to their unique pH-responsive behaviour. Ampicillin sodium salt was utilised as a model drug to analyse drug release behaviour of engineered hydrogel at pH 7.4. The results indicate that these smart hydrogels could be used for injectable controlled drug release (ampicillin sodium) for the treatment of wound as well as for other biomedical applications.
U2 - 10.1016/j.jddst.2024.106462
DO - 10.1016/j.jddst.2024.106462
M3 - Journal article
VL - 104
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
SN - 1773-2247
M1 - 106462
ER -