Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Synthesis of piroxicam loaded novel electrospun biodegradable nanocomposite scaffolds for periodontal regeneration
AU - Farooq, A.
AU - Yar, M.
AU - Khan, A.S.
AU - Shahzadi, L.
AU - Siddiqi, S.A.
AU - Mahmood, N.
AU - Rauf, A.
AU - Qureshi, Z.-U.-A.
AU - Manzoor, F.
AU - Chaudhry, A.A.
AU - Ur Rehman, I.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Development of biodegradable composites having the ability to suppress or eliminate the pathogenic micro-biota or modulate the inflammatory response has attracted great interest in order to limit/repair periodontal tissue destruction. The present report includes the development of non-steroidal anti-inflammatory drug encapsulated novel biodegradable chitosan (CS)/poly(vinyl alcohol) (PVA)/hydroxyapatite (HA) electro-spun (e-spun) composite nanofibrous mats and films and study of the effect of heat treatment on fibers and films morphology. It also describes comparative in-vitro drug release profiles from heat treated and control (non-heat treated) nanofibrous mats and films containing varying concentrations of piroxicam (PX). Electrospinning was used to obtain drug loaded ultrafine fibrous mats. The physical/chemical interactions were evaluated by Fourier Transform Infrared (FT-IR) spectroscopy. The morphology, structure and pore size of the materials were investigated by scanning electron microscopy (SEM). The thermal behavior of the materials was investigated by thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC). Control (not heat treated) and heat treated e-spun fibers mats and films were tested for in vitro drug release studies at physiological pH 7.4 and initially, as per requirement burst release patterns were observed from both fibers and films and later sustained release profiles were noted. In vitro cytocompatibility was performed using VERO cell line of epithelial cells and all the synthesized materials were found to be non-cytotoxic. The current observations suggested that these materials are potential candidates for periodontal regeneration. © 2015 Elsevier B.V. All rights reserved.
AB - Development of biodegradable composites having the ability to suppress or eliminate the pathogenic micro-biota or modulate the inflammatory response has attracted great interest in order to limit/repair periodontal tissue destruction. The present report includes the development of non-steroidal anti-inflammatory drug encapsulated novel biodegradable chitosan (CS)/poly(vinyl alcohol) (PVA)/hydroxyapatite (HA) electro-spun (e-spun) composite nanofibrous mats and films and study of the effect of heat treatment on fibers and films morphology. It also describes comparative in-vitro drug release profiles from heat treated and control (non-heat treated) nanofibrous mats and films containing varying concentrations of piroxicam (PX). Electrospinning was used to obtain drug loaded ultrafine fibrous mats. The physical/chemical interactions were evaluated by Fourier Transform Infrared (FT-IR) spectroscopy. The morphology, structure and pore size of the materials were investigated by scanning electron microscopy (SEM). The thermal behavior of the materials was investigated by thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC). Control (not heat treated) and heat treated e-spun fibers mats and films were tested for in vitro drug release studies at physiological pH 7.4 and initially, as per requirement burst release patterns were observed from both fibers and films and later sustained release profiles were noted. In vitro cytocompatibility was performed using VERO cell line of epithelial cells and all the synthesized materials were found to be non-cytotoxic. The current observations suggested that these materials are potential candidates for periodontal regeneration. © 2015 Elsevier B.V. All rights reserved.
KW - Chitosan
KW - Drug release
KW - NSAIDs
KW - Periodontal regeneration
KW - VERO cells
KW - Cell culture
KW - Chitin
KW - Composite films
KW - Differential scanning calorimetry
KW - Drug products
KW - Fourier transform infrared spectroscopy
KW - Gravimetric analysis
KW - Nanofibers
KW - pH
KW - Pore size
KW - Pyridine
KW - Scanning electron microscopy
KW - Spinning (fibers)
KW - Thermogravimetric analysis
KW - Biodegradable nanocomposites
KW - Fourier transform infra red (FTIR) spectroscopy
KW - Non-steroidal anti-inflammatory drugs
KW - Thermal gravimetric analyses (TGA)
KW - Vero cells
KW - Nanocomposite films
KW - biodegradable plastic
KW - chitosan
KW - hydroxyapatite
KW - nanocomposite
KW - nanofiber
KW - piroxicam
KW - polyvinyl alcohol
KW - animal
KW - cell line
KW - chemistry
KW - Chlorocebus aethiops
KW - drug effects
KW - epithelium cell
KW - infrared spectroscopy
KW - periodontium
KW - procedures
KW - regeneration
KW - scanning electron microscopy
KW - tissue engineering
KW - tissue scaffold
KW - Vero cell line
KW - Animals
KW - Biodegradable Plastics
KW - Cell Line
KW - Cercopithecus aethiops
KW - Durapatite
KW - Epithelial Cells
KW - Microscopy, Electron, Scanning
KW - Nanocomposites
KW - Periodontium
KW - Piroxicam
KW - Polyvinyl Alcohol
KW - Regeneration
KW - Spectroscopy, Fourier Transform Infrared
KW - Tissue Engineering
KW - Tissue Scaffolds
KW - Vero Cells
U2 - 10.1016/j.msec.2015.06.006
DO - 10.1016/j.msec.2015.06.006
M3 - Journal article
VL - 56
SP - 104
EP - 113
JO - Materials Science and Engineering: A
JF - Materials Science and Engineering: A
SN - 0921-5093
ER -