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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei
AU - Abdelwahab, Nuha Z.
AU - Urbaniak, Michael D.
AU - Ferguson, Michael A. J.
AU - Crossman, Arthur T.
N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.
PY - 2011/5/1
Y1 - 2011/5/1
N2 - A small zinc-binding group (ZBG) library of deoxy-2-C-branched-monosaccharides, for example, 1,5-anhydroglucitols, consisting of either monodentate ligand binding carboxylic acids or bidentate ligand binding hydroxamic acids, were prepared to assess the zinc affinity of the putative metalloenzyme 2-acetamido-2-deoxy-α-D-glucopyranosyl-(1→6)-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) of glycosylphosphatidylinositol biosynthesis. The N-ureido thioglucoside was also synthesised and added to the ZBG library because a previous N-ureido analogue, synthesised by us, had inhibitory activity against the aforementioned de-N-acetylase, presumably via the N-ureido motif.
AB - A small zinc-binding group (ZBG) library of deoxy-2-C-branched-monosaccharides, for example, 1,5-anhydroglucitols, consisting of either monodentate ligand binding carboxylic acids or bidentate ligand binding hydroxamic acids, were prepared to assess the zinc affinity of the putative metalloenzyme 2-acetamido-2-deoxy-α-D-glucopyranosyl-(1→6)-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) of glycosylphosphatidylinositol biosynthesis. The N-ureido thioglucoside was also synthesised and added to the ZBG library because a previous N-ureido analogue, synthesised by us, had inhibitory activity against the aforementioned de-N-acetylase, presumably via the N-ureido motif.
KW - Acetylesterase
KW - Enzyme Inhibitors
KW - Glycosylphosphatidylinositols
KW - Magnetic Resonance Spectroscopy
KW - Metalloproteins
KW - Molecular Structure
KW - Trypanosoma brucei brucei
KW - Zinc
U2 - 10.1016/j.carres.2011.02.004
DO - 10.1016/j.carres.2011.02.004
M3 - Journal article
C2 - 21377660
VL - 346
SP - 708
EP - 714
JO - Carbohydrate Research
JF - Carbohydrate Research
SN - 0008-6215
IS - 6
ER -