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Targeted photoredox catalysis in cancer cells

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Targeted photoredox catalysis in cancer cells. / Huang, Huaiyi; Banerjee, Samya; Qiu, Kangqiang; Zhang, Pingyu; Blacque, Olivier; Malcomson, Thomas; Paterson, Martin J.; Clarkson, Guy J.; Staniforth, Michael; Stavros, Vasilios G.; Gasser, Gilles; Chao, Hui; Sadler, Peter J.

In: Nature Chemistry, Vol. 11, No. 11, 01.11.2019, p. 1041-1048.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Huang, H, Banerjee, S, Qiu, K, Zhang, P, Blacque, O, Malcomson, T, Paterson, MJ, Clarkson, GJ, Staniforth, M, Stavros, VG, Gasser, G, Chao, H & Sadler, PJ 2019, 'Targeted photoredox catalysis in cancer cells', Nature Chemistry, vol. 11, no. 11, pp. 1041-1048. https://doi.org/10.1038/s41557-019-0328-4

APA

Huang, H., Banerjee, S., Qiu, K., Zhang, P., Blacque, O., Malcomson, T., Paterson, M. J., Clarkson, G. J., Staniforth, M., Stavros, V. G., Gasser, G., Chao, H., & Sadler, P. J. (2019). Targeted photoredox catalysis in cancer cells. Nature Chemistry, 11(11), 1041-1048. https://doi.org/10.1038/s41557-019-0328-4

Vancouver

Huang H, Banerjee S, Qiu K, Zhang P, Blacque O, Malcomson T et al. Targeted photoredox catalysis in cancer cells. Nature Chemistry. 2019 Nov 1;11(11):1041-1048. https://doi.org/10.1038/s41557-019-0328-4

Author

Huang, Huaiyi ; Banerjee, Samya ; Qiu, Kangqiang ; Zhang, Pingyu ; Blacque, Olivier ; Malcomson, Thomas ; Paterson, Martin J. ; Clarkson, Guy J. ; Staniforth, Michael ; Stavros, Vasilios G. ; Gasser, Gilles ; Chao, Hui ; Sadler, Peter J. / Targeted photoredox catalysis in cancer cells. In: Nature Chemistry. 2019 ; Vol. 11, No. 11. pp. 1041-1048.

Bibtex

@article{3e14b5ca1e7c4c7e8abdd39525a0ca46,
title = "Targeted photoredox catalysis in cancer cells",
abstract = "Hypoxic tumours are a major problem for cancer photodynamic therapy. Here, we show that photoredox catalysis can provide an oxygen-independent mechanism of action to combat this problem. We have designed a highly oxidative Ir(III) photocatalyst, [Ir(ttpy)(pq)Cl]PF6 ([1]PF6, where {\textquoteleft}ttpy{\textquoteright} represents 4′-(p-tolyl)-2,2′:6′,2′′-terpyridine and {\textquoteleft}pq{\textquoteright} represents 3-phenylisoquinoline), which is phototoxic towards both normoxic and hypoxic cancer cells. Complex 1 photocatalytically oxidizes 1,4-dihydronicotinamide adenine dinucleotide (NADH)—an important coenzyme in living cells—generating NAD• radicals with a high turnover frequency in biological media. Moreover, complex 1 and NADH synergistically photoreduce cytochrome c under hypoxia. Density functional theory calculations reveal π stacking in adducts of complex 1 and NADH, facilitating photoinduced single-electron transfer. In cancer cells, complex 1 localizes in mitochondria and disrupts electron transport via NADH photocatalysis. On light irradiation, complex 1 induces NADH depletion, intracellular redox imbalance and immunogenic apoptotic cancer cell death. This photocatalytic redox imbalance strategy offers a new approach for efficient cancer phototherapy.",
author = "Huaiyi Huang and Samya Banerjee and Kangqiang Qiu and Pingyu Zhang and Olivier Blacque and Thomas Malcomson and Paterson, {Martin J.} and Clarkson, {Guy J.} and Michael Staniforth and Stavros, {Vasilios G.} and Gilles Gasser and Hui Chao and Sadler, {Peter J.}",
year = "2019",
month = nov,
day = "1",
doi = "10.1038/s41557-019-0328-4",
language = "English",
volume = "11",
pages = "1041--1048",
journal = "Nature Chemistry",
issn = "1755-4330",
publisher = "Nature Publishing Group",
number = "11",

}

RIS

TY - JOUR

T1 - Targeted photoredox catalysis in cancer cells

AU - Huang, Huaiyi

AU - Banerjee, Samya

AU - Qiu, Kangqiang

AU - Zhang, Pingyu

AU - Blacque, Olivier

AU - Malcomson, Thomas

AU - Paterson, Martin J.

AU - Clarkson, Guy J.

AU - Staniforth, Michael

AU - Stavros, Vasilios G.

AU - Gasser, Gilles

AU - Chao, Hui

AU - Sadler, Peter J.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Hypoxic tumours are a major problem for cancer photodynamic therapy. Here, we show that photoredox catalysis can provide an oxygen-independent mechanism of action to combat this problem. We have designed a highly oxidative Ir(III) photocatalyst, [Ir(ttpy)(pq)Cl]PF6 ([1]PF6, where ‘ttpy’ represents 4′-(p-tolyl)-2,2′:6′,2′′-terpyridine and ‘pq’ represents 3-phenylisoquinoline), which is phototoxic towards both normoxic and hypoxic cancer cells. Complex 1 photocatalytically oxidizes 1,4-dihydronicotinamide adenine dinucleotide (NADH)—an important coenzyme in living cells—generating NAD• radicals with a high turnover frequency in biological media. Moreover, complex 1 and NADH synergistically photoreduce cytochrome c under hypoxia. Density functional theory calculations reveal π stacking in adducts of complex 1 and NADH, facilitating photoinduced single-electron transfer. In cancer cells, complex 1 localizes in mitochondria and disrupts electron transport via NADH photocatalysis. On light irradiation, complex 1 induces NADH depletion, intracellular redox imbalance and immunogenic apoptotic cancer cell death. This photocatalytic redox imbalance strategy offers a new approach for efficient cancer phototherapy.

AB - Hypoxic tumours are a major problem for cancer photodynamic therapy. Here, we show that photoredox catalysis can provide an oxygen-independent mechanism of action to combat this problem. We have designed a highly oxidative Ir(III) photocatalyst, [Ir(ttpy)(pq)Cl]PF6 ([1]PF6, where ‘ttpy’ represents 4′-(p-tolyl)-2,2′:6′,2′′-terpyridine and ‘pq’ represents 3-phenylisoquinoline), which is phototoxic towards both normoxic and hypoxic cancer cells. Complex 1 photocatalytically oxidizes 1,4-dihydronicotinamide adenine dinucleotide (NADH)—an important coenzyme in living cells—generating NAD• radicals with a high turnover frequency in biological media. Moreover, complex 1 and NADH synergistically photoreduce cytochrome c under hypoxia. Density functional theory calculations reveal π stacking in adducts of complex 1 and NADH, facilitating photoinduced single-electron transfer. In cancer cells, complex 1 localizes in mitochondria and disrupts electron transport via NADH photocatalysis. On light irradiation, complex 1 induces NADH depletion, intracellular redox imbalance and immunogenic apoptotic cancer cell death. This photocatalytic redox imbalance strategy offers a new approach for efficient cancer phototherapy.

U2 - 10.1038/s41557-019-0328-4

DO - 10.1038/s41557-019-0328-4

M3 - Journal article

VL - 11

SP - 1041

EP - 1048

JO - Nature Chemistry

JF - Nature Chemistry

SN - 1755-4330

IS - 11

ER -