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Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors. / Murray, Ewan J.; Crowley, Rebecca C.; Truman, Alex et al.
In: Journal of Medicinal Chemistry, Vol. 57, No. 3, 27.03.2014, p. 2813-2819.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Murray, EJ, Crowley, RC, Truman, A, Clarke, SR, Cottam, JA, Jadhav, GP, Steele, VR, O'Shea, P, Lindholm, C, Cockayne, A, Chhabra, SR, Chan, WC & Williams, P 2014, 'Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors', Journal of Medicinal Chemistry, vol. 57, no. 3, pp. 2813-2819. https://doi.org/10.1021/jm500215s

APA

Murray, E. J., Crowley, R. C., Truman, A., Clarke, S. R., Cottam, J. A., Jadhav, G. P., Steele, V. R., O'Shea, P., Lindholm, C., Cockayne, A., Chhabra, S. R., Chan, W. C., & Williams, P. (2014). Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors. Journal of Medicinal Chemistry, 57(3), 2813-2819. https://doi.org/10.1021/jm500215s

Vancouver

Murray EJ, Crowley RC, Truman A, Clarke SR, Cottam JA, Jadhav GP et al. Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors. Journal of Medicinal Chemistry. 2014 Mar 27;57(3):2813-2819. doi: 10.1021/jm500215s

Author

Murray, Ewan J. ; Crowley, Rebecca C. ; Truman, Alex et al. / Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors. In: Journal of Medicinal Chemistry. 2014 ; Vol. 57, No. 3. pp. 2813-2819.

Bibtex

@article{3aaf539d966847f583315506ec315dfd,
title = "Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors",
abstract = "A series of 3-oxo-C12-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing inhibition in Staphylococcus aureus. Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide (AIP) activated AgrC receptor, by altering the activation efficacy of the cognate AIP-1. They appeared to act as negative allosteric modulators and are exemplified by 3-tetradecanoyltetronic acid 17, which reduced nasal cell colonization and arthritis in a murine infection model.",
author = "Murray, {Ewan J.} and Crowley, {Rebecca C.} and Alex Truman and Clarke, {Simon R.} and Cottam, {James A.} and Jadhav, {Gopal P.} and Steele, {Victoria R.} and Paul O'Shea and Catharina Lindholm and Alan Cockayne and Chhabra, {Siri Ram} and Chan, {Weng C.} and Paul Williams",
year = "2014",
month = mar,
day = "27",
doi = "10.1021/jm500215s",
language = "English",
volume = "57",
pages = "2813--2819",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "3",

}

RIS

TY - JOUR

T1 - Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors

AU - Murray, Ewan J.

AU - Crowley, Rebecca C.

AU - Truman, Alex

AU - Clarke, Simon R.

AU - Cottam, James A.

AU - Jadhav, Gopal P.

AU - Steele, Victoria R.

AU - O'Shea, Paul

AU - Lindholm, Catharina

AU - Cockayne, Alan

AU - Chhabra, Siri Ram

AU - Chan, Weng C.

AU - Williams, Paul

PY - 2014/3/27

Y1 - 2014/3/27

N2 - A series of 3-oxo-C12-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing inhibition in Staphylococcus aureus. Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide (AIP) activated AgrC receptor, by altering the activation efficacy of the cognate AIP-1. They appeared to act as negative allosteric modulators and are exemplified by 3-tetradecanoyltetronic acid 17, which reduced nasal cell colonization and arthritis in a murine infection model.

AB - A series of 3-oxo-C12-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing inhibition in Staphylococcus aureus. Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide (AIP) activated AgrC receptor, by altering the activation efficacy of the cognate AIP-1. They appeared to act as negative allosteric modulators and are exemplified by 3-tetradecanoyltetronic acid 17, which reduced nasal cell colonization and arthritis in a murine infection model.

U2 - 10.1021/jm500215s

DO - 10.1021/jm500215s

M3 - Journal article

C2 - 24592914

VL - 57

SP - 2813

EP - 2819

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 3

ER -