Bioinformatics is a discipline that uses computational and mathematical techniques to store, manage, and analyze biological data in order to answer biological questions. Bioinformatics has over 850 databases [154] and numerous tools that work over those databases and local data to produce even more data themselves. In order to perform an analysis, a bioinformatician uses one or more of these resources to gather, filter, and transform data to answer a question. Thus, bioinformatics is an in silico science.