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TGFβ: a sleeping giant awoken by integrins

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TGFβ: a sleeping giant awoken by integrins. / Worthington, John J.; Klementowicz, Joanna E.; Travis, Mark A.
In: Trends in Biochemical Sciences, Vol. 36, No. 1, 01.2011, p. 47-54.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Worthington, JJ, Klementowicz, JE & Travis, MA 2011, 'TGFβ: a sleeping giant awoken by integrins', Trends in Biochemical Sciences, vol. 36, no. 1, pp. 47-54. https://doi.org/10.1016/j.tibs.2010.08.002

APA

Worthington, J. J., Klementowicz, J. E., & Travis, M. A. (2011). TGFβ: a sleeping giant awoken by integrins. Trends in Biochemical Sciences, 36(1), 47-54. https://doi.org/10.1016/j.tibs.2010.08.002

Vancouver

Worthington JJ, Klementowicz JE, Travis MA. TGFβ: a sleeping giant awoken by integrins. Trends in Biochemical Sciences. 2011 Jan;36(1):47-54. Epub 2010 Oct 1. doi: 10.1016/j.tibs.2010.08.002

Author

Worthington, John J. ; Klementowicz, Joanna E. ; Travis, Mark A. / TGFβ : a sleeping giant awoken by integrins. In: Trends in Biochemical Sciences. 2011 ; Vol. 36, No. 1. pp. 47-54.

Bibtex

@article{dc79101426df45fc8319985d585f6d73,
title = "TGFβ: a sleeping giant awoken by integrins",
abstract = "Transforming growth factor beta (TGFβ) controls numerous cellular responses, including proliferation, differentiation, apoptosis and migration. This cytokine is produced by many different cell types and has been implicated in the pathogenesis of many diseases, ranging from autoimmune disorders and infectious diseases to fibrosis and cancer. However, TGFβ is always produced as an inactive complex that must be activated to enable binding to its receptor and subsequent function. Recent evidence highlights a crucial role for members of the integrin receptor family in controlling the activation of TGFβ. These pathways are important in human health and disease, and new insights into the biochemical mechanisms that allow integrins to control TGFβ activation could prove useful in the design of therapeutics.",
keywords = "Animals, Humans, Integrins, Protein Binding, Signal Transduction, Transforming Growth Factor beta",
author = "Worthington, {John J.} and Klementowicz, {Joanna E.} and Travis, {Mark A.}",
note = "Copyright {\^A}{\textcopyright} 2010 Elsevier Ltd. All rights reserved.",
year = "2011",
month = jan,
doi = "10.1016/j.tibs.2010.08.002",
language = "English",
volume = "36",
pages = "47--54",
journal = "Trends in Biochemical Sciences",
issn = "0968-0004",
publisher = "Elsevier Limited",
number = "1",

}

RIS

TY - JOUR

T1 - TGFβ

T2 - a sleeping giant awoken by integrins

AU - Worthington, John J.

AU - Klementowicz, Joanna E.

AU - Travis, Mark A.

N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.

PY - 2011/1

Y1 - 2011/1

N2 - Transforming growth factor beta (TGFβ) controls numerous cellular responses, including proliferation, differentiation, apoptosis and migration. This cytokine is produced by many different cell types and has been implicated in the pathogenesis of many diseases, ranging from autoimmune disorders and infectious diseases to fibrosis and cancer. However, TGFβ is always produced as an inactive complex that must be activated to enable binding to its receptor and subsequent function. Recent evidence highlights a crucial role for members of the integrin receptor family in controlling the activation of TGFβ. These pathways are important in human health and disease, and new insights into the biochemical mechanisms that allow integrins to control TGFβ activation could prove useful in the design of therapeutics.

AB - Transforming growth factor beta (TGFβ) controls numerous cellular responses, including proliferation, differentiation, apoptosis and migration. This cytokine is produced by many different cell types and has been implicated in the pathogenesis of many diseases, ranging from autoimmune disorders and infectious diseases to fibrosis and cancer. However, TGFβ is always produced as an inactive complex that must be activated to enable binding to its receptor and subsequent function. Recent evidence highlights a crucial role for members of the integrin receptor family in controlling the activation of TGFβ. These pathways are important in human health and disease, and new insights into the biochemical mechanisms that allow integrins to control TGFβ activation could prove useful in the design of therapeutics.

KW - Animals

KW - Humans

KW - Integrins

KW - Protein Binding

KW - Signal Transduction

KW - Transforming Growth Factor beta

U2 - 10.1016/j.tibs.2010.08.002

DO - 10.1016/j.tibs.2010.08.002

M3 - Journal article

C2 - 20870411

VL - 36

SP - 47

EP - 54

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

IS - 1

ER -