Home > Research > Publications & Outputs > The Acer gene of Drosophila codes for an angiot...
View graph of relations

The Acer gene of Drosophila codes for an angiotensin-converting enzyme homologue.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published

Standard

The Acer gene of Drosophila codes for an angiotensin-converting enzyme homologue. / Taylor, C. A. M.; Coates, David; Shirras, Alan D.

In: Gene, Vol. 181, No. 1-2, 11.1996, p. 191-197.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

APA

Vancouver

Author

Bibtex

@article{0355453c22434cdcabb0b11a6822c98c,
title = "The Acer gene of Drosophila codes for an angiotensin-converting enzyme homologue.",
abstract = "Mammalian angiotensin-converting enzyme (ACE) exists as two forms, somatic (sACE), controlling blood pressure via angiotensin II, and testicular (tACE), whose function is unknown. The former has two highly homologous N- and C-terminal Zn2+ metallopeptidase active sites, whereas the latter only has one, which is identical to the C-terminal domain of sACE. We have sequenced 2452 bases of a 3.1-kb mRNA whose predicted translation product shows 40% identity with mammalian testicular ACE, and 48% identity with an already identified Drosophila homologue of ACE (Ance). We have termed this gene Acer (Angiotensin converting enzyme-related). Acer mRNA is found in the developing dorsal vessel (heart) during embryogenesis. Phylogenetic analysis indicates that duplication of an ancestral ACE gene occurred in the lineage leading to the arthropods, independently of the duplication which gave rise to the two domain somatic ACE of mammals.",
keywords = "Dipeptidyl dipeptidase, Metalloproteinase, Dna sequencing, Gene duplication, Zn2+-Binding motif, Heart",
author = "Taylor, {C. A. M.} and David Coates and Shirras, {Alan D.}",
year = "1996",
month = nov,
doi = "10.1016/S0378-1119(96)00503-3",
language = "English",
volume = "181",
pages = "191--197",
journal = "Gene",
issn = "0378-1119",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - The Acer gene of Drosophila codes for an angiotensin-converting enzyme homologue.

AU - Taylor, C. A. M.

AU - Coates, David

AU - Shirras, Alan D.

PY - 1996/11

Y1 - 1996/11

N2 - Mammalian angiotensin-converting enzyme (ACE) exists as two forms, somatic (sACE), controlling blood pressure via angiotensin II, and testicular (tACE), whose function is unknown. The former has two highly homologous N- and C-terminal Zn2+ metallopeptidase active sites, whereas the latter only has one, which is identical to the C-terminal domain of sACE. We have sequenced 2452 bases of a 3.1-kb mRNA whose predicted translation product shows 40% identity with mammalian testicular ACE, and 48% identity with an already identified Drosophila homologue of ACE (Ance). We have termed this gene Acer (Angiotensin converting enzyme-related). Acer mRNA is found in the developing dorsal vessel (heart) during embryogenesis. Phylogenetic analysis indicates that duplication of an ancestral ACE gene occurred in the lineage leading to the arthropods, independently of the duplication which gave rise to the two domain somatic ACE of mammals.

AB - Mammalian angiotensin-converting enzyme (ACE) exists as two forms, somatic (sACE), controlling blood pressure via angiotensin II, and testicular (tACE), whose function is unknown. The former has two highly homologous N- and C-terminal Zn2+ metallopeptidase active sites, whereas the latter only has one, which is identical to the C-terminal domain of sACE. We have sequenced 2452 bases of a 3.1-kb mRNA whose predicted translation product shows 40% identity with mammalian testicular ACE, and 48% identity with an already identified Drosophila homologue of ACE (Ance). We have termed this gene Acer (Angiotensin converting enzyme-related). Acer mRNA is found in the developing dorsal vessel (heart) during embryogenesis. Phylogenetic analysis indicates that duplication of an ancestral ACE gene occurred in the lineage leading to the arthropods, independently of the duplication which gave rise to the two domain somatic ACE of mammals.

KW - Dipeptidyl dipeptidase

KW - Metalloproteinase

KW - Dna sequencing

KW - Gene duplication

KW - Zn2+-Binding motif

KW - Heart

U2 - 10.1016/S0378-1119(96)00503-3

DO - 10.1016/S0378-1119(96)00503-3

M3 - Journal article

VL - 181

SP - 191

EP - 197

JO - Gene

JF - Gene

SN - 0378-1119

IS - 1-2

ER -