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The action of a mast cell protease on the cuticular collagens of Necator americanus.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

<mark>Journal publication date</mark>05/1989
<mark>Journal</mark>Parasite Immunology
Issue number3
Number of pages5
Pages (from-to)293-297
Publication StatusPublished
<mark>Original language</mark>English


Collagen-like proteins, thought to be responsible for maintaining the structural integrity of the nematode cuticle, were isolated from adult Necator americanus and shown to be susceptible to digestion by purified mast cell proteases. Although these collagens would appear normally to be masked by superficially expressed (surface) antigens, it is suggested that a sufficiently avid and specific immune response could remove this potentially protective coat, rendering the structurally important underlying layers open to immune attack.