TY - JOUR

T1 - The allo-epi-endothelial lining of the intervillous space.

AU - Ockleford, C. D.

PY - 2010/12

Y1 - 2010/12

N2 - An unusual monolayer of cells lines the interface between the basal plate and the intervillous space in human term placenta but not the chorionic villi. Our recent descriptions of it are based on advanced microscopy, phenotyping and cytogenetic approaches. The papers show that the layer is partly epithelial (ectoderm) and partly endothelial (mesoderm): it is partly derived from the fetus and partly from the mother. This first accurate description of a naturally occurring human allo-epi-endothelium (monolayer of cells derived from two embryological germ layers and two individuals) is of interest in anatomy, obstetrics and gynaecology, developmental biology, histology and immunology. The most extensive evidence for this mosaic applies to the intervillous space lining layer of the basal plate where the endothelial proportion is of the order of 50%; it extends throughout central, intermediate and peripheral parts of the basal plate and is a consistent feature of the intervillous space lining of the chorionic plate also. Its presence lining chorionic plate is noteworthy as it includes the furthest parts of the sinus from the supplying and draining vessels which are endothelial lined.

AB - An unusual monolayer of cells lines the interface between the basal plate and the intervillous space in human term placenta but not the chorionic villi. Our recent descriptions of it are based on advanced microscopy, phenotyping and cytogenetic approaches. The papers show that the layer is partly epithelial (ectoderm) and partly endothelial (mesoderm): it is partly derived from the fetus and partly from the mother. This first accurate description of a naturally occurring human allo-epi-endothelium (monolayer of cells derived from two embryological germ layers and two individuals) is of interest in anatomy, obstetrics and gynaecology, developmental biology, histology and immunology. The most extensive evidence for this mosaic applies to the intervillous space lining layer of the basal plate where the endothelial proportion is of the order of 50%; it extends throughout central, intermediate and peripheral parts of the basal plate and is a consistent feature of the intervillous space lining of the chorionic plate also. Its presence lining chorionic plate is noteworthy as it includes the furthest parts of the sinus from the supplying and draining vessels which are endothelial lined.

KW - Intervillous space lining

KW - Mosaic monolayer

KW - Endothelium

KW - Pre-eclampsia

KW - Anchoring villous

KW - Small for gestational age

KW - Allo-epi-endothelium

KW - Stem cells

KW - Germ layer theory

UR - http://www.scopus.com/inward/record.url?scp=78649450570&partnerID=8YFLogxK

U2 - 10.1016/j.placenta.2010.09.007

DO - 10.1016/j.placenta.2010.09.007

M3 - Journal article

VL - 31

SP - 1035

EP - 1042

JO - Placenta

JF - Placenta

SN - 0143-4004

IS - 12

ER -