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The Bipolar Association Case-Control Study (BACCS) and meta-analysis: no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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The Bipolar Association Case-Control Study (BACCS) and meta-analysis: no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder. / Cohen-Woods, Sarah; Craig, Ian; Gaysina, Darya et al.
In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , Vol. 153B, No. 7, 05.10.2010, p. 1298-1304.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Cohen-Woods, S, Craig, I, Gaysina, D, Gray, J, Gunasinghe, C, Craddock, N, Elkin, A, Jones, L, Kennedy, J, King, N, Korszun, A, Knight, J, Owen, M, Parikh, S, Strauss, J, Sterne, A, Tozzi, F, Perry, J, Muglia, P, Vincent, J, McGuffin, P & Farmer, A 2010, 'The Bipolar Association Case-Control Study (BACCS) and meta-analysis: no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , vol. 153B, no. 7, pp. 1298-1304. https://doi.org/10.1002/ajmg.b.31101

APA

Cohen-Woods, S., Craig, I., Gaysina, D., Gray, J., Gunasinghe, C., Craddock, N., Elkin, A., Jones, L., Kennedy, J., King, N., Korszun, A., Knight, J., Owen, M., Parikh, S., Strauss, J., Sterne, A., Tozzi, F., Perry, J., Muglia, P., ... Farmer, A. (2010). The Bipolar Association Case-Control Study (BACCS) and meta-analysis: no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , 153B(7), 1298-1304. https://doi.org/10.1002/ajmg.b.31101

Vancouver

Cohen-Woods S, Craig I, Gaysina D, Gray J, Gunasinghe C, Craddock N et al. The Bipolar Association Case-Control Study (BACCS) and meta-analysis: no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 2010 Oct 5;153B(7):1298-1304. Epub 2010 Jun 15. doi: 10.1002/ajmg.b.31101

Author

Cohen-Woods, Sarah ; Craig, Ian ; Gaysina, Darya et al. / The Bipolar Association Case-Control Study (BACCS) and meta-analysis : no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder. In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 2010 ; Vol. 153B, No. 7. pp. 1298-1304.

Bibtex

@article{0d9c7347634b4bc8b7fda30772105230,
title = "The Bipolar Association Case-Control Study (BACCS) and meta-analysis: no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder",
abstract = "Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.",
keywords = "Alleles, Bipolar Disorder, Case-Control Studies, Genetic Association Studies, Genotype, Humans, Methylenetetrahydrofolate Reductase (NADPH2), Polymorphism, Single Nucleotide",
author = "Sarah Cohen-Woods and Ian Craig and Darya Gaysina and Joanna Gray and Cerisse Gunasinghe and Nick Craddock and Amanda Elkin and Lisa Jones and James Kennedy and Nicole King and Ania Korszun and Jo Knight and Michael Owen and Sagar Parikh and John Strauss and Abram Sterne and Federica Tozzi and Julia Perry and Pierandrea Muglia and John Vincent and Peter McGuffin and Anne Farmer",
year = "2010",
month = oct,
day = "5",
doi = "10.1002/ajmg.b.31101",
language = "English",
volume = "153B",
pages = "1298--1304",
journal = "American Journal of Medical Genetics Part B: Neuropsychiatric Genetics ",
issn = "1552-4841",
publisher = "Wiley-Liss Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - The Bipolar Association Case-Control Study (BACCS) and meta-analysis

T2 - no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder

AU - Cohen-Woods, Sarah

AU - Craig, Ian

AU - Gaysina, Darya

AU - Gray, Joanna

AU - Gunasinghe, Cerisse

AU - Craddock, Nick

AU - Elkin, Amanda

AU - Jones, Lisa

AU - Kennedy, James

AU - King, Nicole

AU - Korszun, Ania

AU - Knight, Jo

AU - Owen, Michael

AU - Parikh, Sagar

AU - Strauss, John

AU - Sterne, Abram

AU - Tozzi, Federica

AU - Perry, Julia

AU - Muglia, Pierandrea

AU - Vincent, John

AU - McGuffin, Peter

AU - Farmer, Anne

PY - 2010/10/5

Y1 - 2010/10/5

N2 - Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.

AB - Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.

KW - Alleles

KW - Bipolar Disorder

KW - Case-Control Studies

KW - Genetic Association Studies

KW - Genotype

KW - Humans

KW - Methylenetetrahydrofolate Reductase (NADPH2)

KW - Polymorphism, Single Nucleotide

U2 - 10.1002/ajmg.b.31101

DO - 10.1002/ajmg.b.31101

M3 - Journal article

C2 - 20552676

VL - 153B

SP - 1298

EP - 1304

JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 7

ER -