TY - JOUR

T1 - The effect of social deprivation on clinical outcomes and the use of treatments in the UK cystic fibrosis population

T2 - a longitudinal study

AU - Taylor-Robinson, David C.

AU - Smyth, Rosalind L.

AU - Diggle, Peter J.

AU - Whitehead, Margaret

PY - 2013/4

Y1 - 2013/4

N2 - BackgroundPoorer socioeconomic circumstances have been linked with worse outcomes in cystic fibrosis. We assessed whether a relation exists between social deprivation and individual's clinical and health-care outcomes.MethodsWe did a longitudinal registry study of the UK cystic fibrosis population younger than 40 years (8055 people with 49 337 observations for weight, the most commonly collected outcome, between Jan 1, 1996, and Dec 31, 2009). We assessed data for weight, height, body-mass index, percent predicted forced expiratory volume in 1 s (%FEV1), risk of Pseudomonas aeruginosa colonisation, and the use of major cystic fibrosis treatment modalities. We used mixed effects models to assess the association between small-area deprivation and clinical and health-care outcomes, adjusting for clinically important covariates. We give continuous outcomes as mean differences, and binary outcomes as odds ratios, comparing extremes of deprivation quintile.FindingsCompared with the least deprived areas, children from the most deprived areas weighed less (standard deviation [SD] score −0·28, 95% CI −0·38 to −0·18), were shorter (–0·31, −0·40 to −0·21, and had a lower body-mass index (–0·13, −0·22 to −0·04), were more likely to have chronic P aeruginosa infection (odds ratio 1·89, 95% CI 1·34 to 2·66), and have a lower %FEV1 (–4·12 percentage points, 95% CI −5·01 to −3·19). These inequalities were apparent very early in life and did not widen thereafter. On a population level, after adjustment for disease severity, children in the most deprived quintile were more likely to receive intravenous antibiotics (odds ratio 2·52, 95% CI 1·92 to 3·17) and nutritional treatments (1·78, 1·44 to 2·20) compared with individuals in the least deprived quintile. Patients from the most disadvantaged areas were less likely to receive DNase or inhaled antibiotic treatment.InterpretationIn the UK, children with cystic fibrosis from more disadvantaged areas have worse growth and lung function compared with children from more affluent areas, but these inequalities do not widen with advancing age. Clinicians consider deprivation status, as well as disease status, when making decisions about treatments, and this might mitigate some effects of social disadvantage.

AB - BackgroundPoorer socioeconomic circumstances have been linked with worse outcomes in cystic fibrosis. We assessed whether a relation exists between social deprivation and individual's clinical and health-care outcomes.MethodsWe did a longitudinal registry study of the UK cystic fibrosis population younger than 40 years (8055 people with 49 337 observations for weight, the most commonly collected outcome, between Jan 1, 1996, and Dec 31, 2009). We assessed data for weight, height, body-mass index, percent predicted forced expiratory volume in 1 s (%FEV1), risk of Pseudomonas aeruginosa colonisation, and the use of major cystic fibrosis treatment modalities. We used mixed effects models to assess the association between small-area deprivation and clinical and health-care outcomes, adjusting for clinically important covariates. We give continuous outcomes as mean differences, and binary outcomes as odds ratios, comparing extremes of deprivation quintile.FindingsCompared with the least deprived areas, children from the most deprived areas weighed less (standard deviation [SD] score −0·28, 95% CI −0·38 to −0·18), were shorter (–0·31, −0·40 to −0·21, and had a lower body-mass index (–0·13, −0·22 to −0·04), were more likely to have chronic P aeruginosa infection (odds ratio 1·89, 95% CI 1·34 to 2·66), and have a lower %FEV1 (–4·12 percentage points, 95% CI −5·01 to −3·19). These inequalities were apparent very early in life and did not widen thereafter. On a population level, after adjustment for disease severity, children in the most deprived quintile were more likely to receive intravenous antibiotics (odds ratio 2·52, 95% CI 1·92 to 3·17) and nutritional treatments (1·78, 1·44 to 2·20) compared with individuals in the least deprived quintile. Patients from the most disadvantaged areas were less likely to receive DNase or inhaled antibiotic treatment.InterpretationIn the UK, children with cystic fibrosis from more disadvantaged areas have worse growth and lung function compared with children from more affluent areas, but these inequalities do not widen with advancing age. Clinicians consider deprivation status, as well as disease status, when making decisions about treatments, and this might mitigate some effects of social disadvantage.

U2 - 10.1016/S2213-2600(13)70002-X

DO - 10.1016/S2213-2600(13)70002-X

M3 - Journal article

C2 - 24429092

VL - 1

SP - 121

EP - 128

JO - Lancet Respiratory Medicine

JF - Lancet Respiratory Medicine

SN - 2213-2600

IS - 2

ER -