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The effect of Staphylococcus aureus carriage in late pregnancy on antibody levels to staphylococcal toxins in cord blood and breast milk.

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The effect of Staphylococcus aureus carriage in late pregnancy on antibody levels to staphylococcal toxins in cord blood and breast milk. / Harrison, Linda M.; Morris, James A.; Lauder, Robert M. et al.
In: FEMS Immunology and Medical Microbiology, Vol. 54, No. 1, 2008, p. 137-143.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Harrison, LM, Morris, JA, Lauder, RM & Telford, DR 2008, 'The effect of Staphylococcus aureus carriage in late pregnancy on antibody levels to staphylococcal toxins in cord blood and breast milk.', FEMS Immunology and Medical Microbiology, vol. 54, no. 1, pp. 137-143. https://doi.org/10.1111/j.1574-695X.2008.00463.x

APA

Harrison, L. M., Morris, J. A., Lauder, R. M., & Telford, D. R. (2008). The effect of Staphylococcus aureus carriage in late pregnancy on antibody levels to staphylococcal toxins in cord blood and breast milk. FEMS Immunology and Medical Microbiology, 54(1), 137-143. https://doi.org/10.1111/j.1574-695X.2008.00463.x

Vancouver

Harrison LM, Morris JA, Lauder RM, Telford DR. The effect of Staphylococcus aureus carriage in late pregnancy on antibody levels to staphylococcal toxins in cord blood and breast milk. FEMS Immunology and Medical Microbiology. 2008;54(1):137-143. doi: 10.1111/j.1574-695X.2008.00463.x

Author

Harrison, Linda M. ; Morris, James A. ; Lauder, Robert M. et al. / The effect of Staphylococcus aureus carriage in late pregnancy on antibody levels to staphylococcal toxins in cord blood and breast milk. In: FEMS Immunology and Medical Microbiology. 2008 ; Vol. 54, No. 1. pp. 137-143.

Bibtex

@article{d4aa24956c20416a8b3b7c65858cf7de,
title = "The effect of Staphylococcus aureus carriage in late pregnancy on antibody levels to staphylococcal toxins in cord blood and breast milk.",
abstract = "We investigated the effect of carriage of Staphylococcus aureus in the later stages of pregnancy on levels of antibody specific to the S. aureus toxins, staphylococcal enterotoxin B (SEB), staphylococcal enterotoxin C (SEC) and toxic shock syndrome toxin-1 (TSST-1), in cord blood and breast milk and also explored the relationship between levels of antibody in antenatal serum and cord blood. Nasopharyngeal swabs and stool samples were collected on two occasions, from 96 women, during the last 6 weeks of pregnancy. Samples were cultured and S. aureus isolates were identified. Antenatal and cord blood samples from the same women and their infants were analysed for IgG antibody to SEB, SEC and TSST-1 by enzyme-linked immunosorbent assay. Breast milk samples were analysed for IgA antibody to the same toxins. We found that S. aureus carriage in pregnancy is common and exposure to a toxin-producing isolate boosts immunity. Over 89% of women and infants have some protective antibody to the toxins, and antitoxin IgG levels are higher in cord blood samples compared with antenatal samples. Levels of cord blood IgG and breast milk IgA specific for the staphylococcal toxins vary. Some infants lack protection and could be at risk of toxin-induced disease.",
keywords = "Staphylococcus aureus, pregnancy, staphylococcal toxins, antibody levels, cord blood, breast milk",
author = "Harrison, {Linda M.} and Morris, {James A.} and Lauder, {Robert M.} and Telford, {David R.}",
year = "2008",
doi = "10.1111/j.1574-695X.2008.00463.x",
language = "English",
volume = "54",
pages = "137--143",
journal = "FEMS Immunology and Medical Microbiology",
issn = "1574-695X",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - The effect of Staphylococcus aureus carriage in late pregnancy on antibody levels to staphylococcal toxins in cord blood and breast milk.

AU - Harrison, Linda M.

AU - Morris, James A.

AU - Lauder, Robert M.

AU - Telford, David R.

PY - 2008

Y1 - 2008

N2 - We investigated the effect of carriage of Staphylococcus aureus in the later stages of pregnancy on levels of antibody specific to the S. aureus toxins, staphylococcal enterotoxin B (SEB), staphylococcal enterotoxin C (SEC) and toxic shock syndrome toxin-1 (TSST-1), in cord blood and breast milk and also explored the relationship between levels of antibody in antenatal serum and cord blood. Nasopharyngeal swabs and stool samples were collected on two occasions, from 96 women, during the last 6 weeks of pregnancy. Samples were cultured and S. aureus isolates were identified. Antenatal and cord blood samples from the same women and their infants were analysed for IgG antibody to SEB, SEC and TSST-1 by enzyme-linked immunosorbent assay. Breast milk samples were analysed for IgA antibody to the same toxins. We found that S. aureus carriage in pregnancy is common and exposure to a toxin-producing isolate boosts immunity. Over 89% of women and infants have some protective antibody to the toxins, and antitoxin IgG levels are higher in cord blood samples compared with antenatal samples. Levels of cord blood IgG and breast milk IgA specific for the staphylococcal toxins vary. Some infants lack protection and could be at risk of toxin-induced disease.

AB - We investigated the effect of carriage of Staphylococcus aureus in the later stages of pregnancy on levels of antibody specific to the S. aureus toxins, staphylococcal enterotoxin B (SEB), staphylococcal enterotoxin C (SEC) and toxic shock syndrome toxin-1 (TSST-1), in cord blood and breast milk and also explored the relationship between levels of antibody in antenatal serum and cord blood. Nasopharyngeal swabs and stool samples were collected on two occasions, from 96 women, during the last 6 weeks of pregnancy. Samples were cultured and S. aureus isolates were identified. Antenatal and cord blood samples from the same women and their infants were analysed for IgG antibody to SEB, SEC and TSST-1 by enzyme-linked immunosorbent assay. Breast milk samples were analysed for IgA antibody to the same toxins. We found that S. aureus carriage in pregnancy is common and exposure to a toxin-producing isolate boosts immunity. Over 89% of women and infants have some protective antibody to the toxins, and antitoxin IgG levels are higher in cord blood samples compared with antenatal samples. Levels of cord blood IgG and breast milk IgA specific for the staphylococcal toxins vary. Some infants lack protection and could be at risk of toxin-induced disease.

KW - Staphylococcus aureus

KW - pregnancy

KW - staphylococcal toxins

KW - antibody levels

KW - cord blood

KW - breast milk

UR - http://www.scopus.com/inward/record.url?scp=51349098811&partnerID=8YFLogxK

U2 - 10.1111/j.1574-695X.2008.00463.x

DO - 10.1111/j.1574-695X.2008.00463.x

M3 - Journal article

VL - 54

SP - 137

EP - 143

JO - FEMS Immunology and Medical Microbiology

JF - FEMS Immunology and Medical Microbiology

SN - 1574-695X

IS - 1

ER -