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The effects of nested miRNAs and their host genes on immune defense against Bacillus thuringiensis infection in Caenorhabditis elegans

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The effects of nested miRNAs and their host genes on immune defense against Bacillus thuringiensis infection in Caenorhabditis elegans. / Zárate-Potes, Alejandra; Yang, Wentao; Andresen, Bentje et al.

In: Developmental and comparative immunology, Vol. 123, 104144, 31.10.2021.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Zárate-Potes, A, Yang, W, Andresen, B, Nakad, R, Haase, D, Rosenstiel, P, Dierking, K & Schulenburg, H 2021, 'The effects of nested miRNAs and their host genes on immune defense against Bacillus thuringiensis infection in Caenorhabditis elegans', Developmental and comparative immunology, vol. 123, 104144. https://doi.org/10.1016/j.dci.2021.104144

APA

Zárate-Potes, A., Yang, W., Andresen, B., Nakad, R., Haase, D., Rosenstiel, P., Dierking, K., & Schulenburg, H. (2021). The effects of nested miRNAs and their host genes on immune defense against Bacillus thuringiensis infection in Caenorhabditis elegans. Developmental and comparative immunology, 123, [104144]. https://doi.org/10.1016/j.dci.2021.104144

Vancouver

Zárate-Potes A, Yang W, Andresen B, Nakad R, Haase D, Rosenstiel P et al. The effects of nested miRNAs and their host genes on immune defense against Bacillus thuringiensis infection in Caenorhabditis elegans. Developmental and comparative immunology. 2021 Oct 31;123:104144. Epub 2021 Jun 3. doi: 10.1016/j.dci.2021.104144

Author

Zárate-Potes, Alejandra ; Yang, Wentao ; Andresen, Bentje et al. / The effects of nested miRNAs and their host genes on immune defense against Bacillus thuringiensis infection in Caenorhabditis elegans. In: Developmental and comparative immunology. 2021 ; Vol. 123.

Bibtex

@article{782e514c397646bcae31feabf0fcb150,
title = "The effects of nested miRNAs and their host genes on immune defense against Bacillus thuringiensis infection in Caenorhabditis elegans",
abstract = "microRNAs (miRNAs) are small non-coding RNA-molecules that influence translation by binding to the target gene mRNA. Many miRNAs are found in nested arrangements within larger protein-coding host genes. miRNAs and host genes in a nested arrangement are often transcribed simultaneously, which may indicate that both have similar functions. miRNAs have been implicated in regulating defense responses against pathogen infection in C. elegans and in mammals. Here, we asked if miRNAs in nested arrangements and their host genes are involved in the C. elegans response against infection with Bacillus thuringiensis (Bt). We performed miRNA sequencing and subsequently focused on four nested miRNA-host gene arrangements for a functional genetic analysis. We identified mir-58.1 and mir-2 as negative regulators of C. elegans resistance to Bt infection. However, we did not find any miRNA/host gene pair in which both contribute to defense against Bt.",
keywords = "Animals, Bacillus thuringiensis/physiology, Caenorhabditis elegans/immunology, Caenorhabditis elegans Proteins/genetics, Disease Resistance, Gram-Positive Bacterial Infections/immunology, Host-Pathogen Interactions, Immunity, Innate, MicroRNAs/genetics, Sequence Analysis, RNA",
author = "Alejandra Z{\'a}rate-Potes and Wentao Yang and Bentje Andresen and Rania Nakad and Daniela Haase and Philip Rosenstiel and Katja Dierking and Hinrich Schulenburg",
year = "2021",
month = oct,
day = "31",
doi = "10.1016/j.dci.2021.104144",
language = "English",
volume = "123",
journal = "Developmental and comparative immunology",
issn = "0145-305X",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - The effects of nested miRNAs and their host genes on immune defense against Bacillus thuringiensis infection in Caenorhabditis elegans

AU - Zárate-Potes, Alejandra

AU - Yang, Wentao

AU - Andresen, Bentje

AU - Nakad, Rania

AU - Haase, Daniela

AU - Rosenstiel, Philip

AU - Dierking, Katja

AU - Schulenburg, Hinrich

PY - 2021/10/31

Y1 - 2021/10/31

N2 - microRNAs (miRNAs) are small non-coding RNA-molecules that influence translation by binding to the target gene mRNA. Many miRNAs are found in nested arrangements within larger protein-coding host genes. miRNAs and host genes in a nested arrangement are often transcribed simultaneously, which may indicate that both have similar functions. miRNAs have been implicated in regulating defense responses against pathogen infection in C. elegans and in mammals. Here, we asked if miRNAs in nested arrangements and their host genes are involved in the C. elegans response against infection with Bacillus thuringiensis (Bt). We performed miRNA sequencing and subsequently focused on four nested miRNA-host gene arrangements for a functional genetic analysis. We identified mir-58.1 and mir-2 as negative regulators of C. elegans resistance to Bt infection. However, we did not find any miRNA/host gene pair in which both contribute to defense against Bt.

AB - microRNAs (miRNAs) are small non-coding RNA-molecules that influence translation by binding to the target gene mRNA. Many miRNAs are found in nested arrangements within larger protein-coding host genes. miRNAs and host genes in a nested arrangement are often transcribed simultaneously, which may indicate that both have similar functions. miRNAs have been implicated in regulating defense responses against pathogen infection in C. elegans and in mammals. Here, we asked if miRNAs in nested arrangements and their host genes are involved in the C. elegans response against infection with Bacillus thuringiensis (Bt). We performed miRNA sequencing and subsequently focused on four nested miRNA-host gene arrangements for a functional genetic analysis. We identified mir-58.1 and mir-2 as negative regulators of C. elegans resistance to Bt infection. However, we did not find any miRNA/host gene pair in which both contribute to defense against Bt.

KW - Animals

KW - Bacillus thuringiensis/physiology

KW - Caenorhabditis elegans/immunology

KW - Caenorhabditis elegans Proteins/genetics

KW - Disease Resistance

KW - Gram-Positive Bacterial Infections/immunology

KW - Host-Pathogen Interactions

KW - Immunity, Innate

KW - MicroRNAs/genetics

KW - Sequence Analysis, RNA

U2 - 10.1016/j.dci.2021.104144

DO - 10.1016/j.dci.2021.104144

M3 - Journal article

C2 - 34051205

VL - 123

JO - Developmental and comparative immunology

JF - Developmental and comparative immunology

SN - 0145-305X

M1 - 104144

ER -