Rights statement: This is the peer reviewed version of the following article: Jones SH, Knowles D, Tyler E, et al. The feasibility and acceptability of a novel anxiety in bipolar disorder intervention compared to treatment as usual: A randomized controlled trial. Depress Anxiety. 2018;35:953–965. https://doi.org/10.1002/da.22781 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/da.22781/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - The feasibility and acceptability of a novel anxiety in bipolar disorder intervention compared to treatment as usual
T2 - a randomized controlled trial
AU - Jones, Steven Huntley
AU - Knowles, Dawn
AU - Tyler, Elizabeth
AU - Holland, Fiona
AU - Peters, Sarah
AU - Lobban, Anne Fiona
AU - Langshaw, Brian
AU - Hilton, Claire Alexandra
AU - Long, Rita Marie
AU - Gantt, Kay
AU - Owen, Rebecca Louise
AU - Roberts, Christopher
AU - Riste, Lisa Kate
N1 - This is the peer reviewed version of the following article: Jones SH, Knowles D, Tyler E, et al. The feasibility and acceptability of a novel anxiety in bipolar disorder intervention compared to treatment as usual: A randomized controlled trial. Depress Anxiety. 2018;35:953–965. https://doi.org/10.1002/da.22781 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/da.22781/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
PY - 2018/10
Y1 - 2018/10
N2 - 1 BackgroundComorbid anxiety is common in bipolar disorder (BD) and associated with worse clinical outcomes including increased suicidality. Despite effective psychological treatments for anxiety, research into treating anxiety in BD is underdeveloped. This paper describes a novel psychological intervention to address anxiety in context of bipolar disorder (AIBD).2 MethodsAdults with BD and clinically significant anxiety symptoms were randomized to AIBD plus treatment as usual (TAU) or TAU alone. AIBD offered 10 sessions of psychological therapy using a formulation‐based approach. Feasibility and acceptability were evaluated through recruitment, retention, therapy attendance, alliance, fidelity, and qualitative feedback. Clinical outcomes were assessed at baseline, 16, 48, and 80 weeks: interim assessments of relapse at 32 and 64 weeks.3 ResultsSeventy‐two participants were recruited with 88% retention to 16 weeks and 74% to 80 weeks (similar between arms). Therapy participants attended urn:x-wiley:10914269:media:da22781:da22781-math-00017.7 (SD 2.8) sessions. Therapeutic alliance and therapy fidelity were acceptable. Qualitative interviews indicated that participants valued integrated support for anxiety with BD and coping strategies. Some suggested a longer intervention period. Clinical outcomes were not significantly different between arms up to 80 weeks follow‐up.4 ConclusionsAIBD is feasible and acceptable but lack of impact on clinical outcomes indicates that adaptations are required. These are discussed in relation to qualitative feedback and recent literature published since the trial completed.
AB - 1 BackgroundComorbid anxiety is common in bipolar disorder (BD) and associated with worse clinical outcomes including increased suicidality. Despite effective psychological treatments for anxiety, research into treating anxiety in BD is underdeveloped. This paper describes a novel psychological intervention to address anxiety in context of bipolar disorder (AIBD).2 MethodsAdults with BD and clinically significant anxiety symptoms were randomized to AIBD plus treatment as usual (TAU) or TAU alone. AIBD offered 10 sessions of psychological therapy using a formulation‐based approach. Feasibility and acceptability were evaluated through recruitment, retention, therapy attendance, alliance, fidelity, and qualitative feedback. Clinical outcomes were assessed at baseline, 16, 48, and 80 weeks: interim assessments of relapse at 32 and 64 weeks.3 ResultsSeventy‐two participants were recruited with 88% retention to 16 weeks and 74% to 80 weeks (similar between arms). Therapy participants attended urn:x-wiley:10914269:media:da22781:da22781-math-00017.7 (SD 2.8) sessions. Therapeutic alliance and therapy fidelity were acceptable. Qualitative interviews indicated that participants valued integrated support for anxiety with BD and coping strategies. Some suggested a longer intervention period. Clinical outcomes were not significantly different between arms up to 80 weeks follow‐up.4 ConclusionsAIBD is feasible and acceptable but lack of impact on clinical outcomes indicates that adaptations are required. These are discussed in relation to qualitative feedback and recent literature published since the trial completed.
KW - Bipolar disorder
KW - Anxiety/Anxiety disorders
KW - CBT/cognitive behavior therapy
KW - mood disorders
KW - Clinical Trials
U2 - 10.1002/da.22781
DO - 10.1002/da.22781
M3 - Journal article
VL - 35
SP - 953
EP - 965
JO - Depression and Anxiety
JF - Depression and Anxiety
SN - 1091-4269
IS - 10
ER -