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The first Non-LRV RNA virus in leishmania

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The first Non-LRV RNA virus in leishmania. / Grybchuk, D.; MacEdo, D.H.; Kleschenko, Y. et al.
In: Viruses, Vol. 12, No. 2, 168, 02.02.2020.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Grybchuk, D, MacEdo, DH, Kleschenko, Y, Kraeva, N, Lukashev, AN, Bates, PA, Kulich, P, Leštinová, T, Volf, P, Kostygov, AY & Yurchenko, V 2020, 'The first Non-LRV RNA virus in leishmania', Viruses, vol. 12, no. 2, 168. https://doi.org/10.3390/v12020168

APA

Grybchuk, D., MacEdo, D. H., Kleschenko, Y., Kraeva, N., Lukashev, A. N., Bates, P. A., Kulich, P., Leštinová, T., Volf, P., Kostygov, A. Y., & Yurchenko, V. (2020). The first Non-LRV RNA virus in leishmania. Viruses, 12(2), Article 168. https://doi.org/10.3390/v12020168

Vancouver

Grybchuk D, MacEdo DH, Kleschenko Y, Kraeva N, Lukashev AN, Bates PA et al. The first Non-LRV RNA virus in leishmania. Viruses. 2020 Feb 2;12(2):168. doi: 10.3390/v12020168

Author

Grybchuk, D. ; MacEdo, D.H. ; Kleschenko, Y. et al. / The first Non-LRV RNA virus in leishmania. In: Viruses. 2020 ; Vol. 12, No. 2.

Bibtex

@article{71931c49db3d49d992b0a0bd2498c136,
title = "The first Non-LRV RNA virus in leishmania",
abstract = "In this work, we describe the first Leishmania-infecting leishbunyavirus—the first virus other than Leishmania RNA virus (LRV) found in trypanosomatid parasites. Its host is Leishmania martiniquensis, a human pathogen causing infections with a wide range of manifestations from asymptomatic to severe visceral disease. This virus (LmarLBV1) possesses many characteristic features of leishbunyaviruses, such as tripartite organization of its RNA genome, with ORFs encoding RNA-dependent RNA polymerase, surface glycoprotein, and nucleoprotein on L, M, and S segments, respectively. Our phylogenetic analyses suggest that LmarLBV1 originated from leishbunyaviruses of monoxenous trypanosomatids and, probably, is a result of genomic re-assortment. The LmarLBV1 facilitates parasites{\textquoteright} infectivity in vitro in primary murine macrophages model. The discovery of a virus in L. martiniquensis poses the question of whether it influences pathogenicity of this parasite in vivo, similarly to the LRV in other Leishmania species.",
keywords = "Bunyavirales, Leishmania martiniquensis, leishbunyavirus",
author = "D. Grybchuk and D.H. MacEdo and Y. Kleschenko and N. Kraeva and A.N. Lukashev and P.A. Bates and P. Kulich and T. Le{\v s}tinov{\'a} and P. Volf and A.Y. Kostygov and V. Yurchenko",
year = "2020",
month = feb,
day = "2",
doi = "10.3390/v12020168",
language = "English",
volume = "12",
journal = "Viruses",
issn = "1999-4915",
publisher = "MDPI AG",
number = "2",

}

RIS

TY - JOUR

T1 - The first Non-LRV RNA virus in leishmania

AU - Grybchuk, D.

AU - MacEdo, D.H.

AU - Kleschenko, Y.

AU - Kraeva, N.

AU - Lukashev, A.N.

AU - Bates, P.A.

AU - Kulich, P.

AU - Leštinová, T.

AU - Volf, P.

AU - Kostygov, A.Y.

AU - Yurchenko, V.

PY - 2020/2/2

Y1 - 2020/2/2

N2 - In this work, we describe the first Leishmania-infecting leishbunyavirus—the first virus other than Leishmania RNA virus (LRV) found in trypanosomatid parasites. Its host is Leishmania martiniquensis, a human pathogen causing infections with a wide range of manifestations from asymptomatic to severe visceral disease. This virus (LmarLBV1) possesses many characteristic features of leishbunyaviruses, such as tripartite organization of its RNA genome, with ORFs encoding RNA-dependent RNA polymerase, surface glycoprotein, and nucleoprotein on L, M, and S segments, respectively. Our phylogenetic analyses suggest that LmarLBV1 originated from leishbunyaviruses of monoxenous trypanosomatids and, probably, is a result of genomic re-assortment. The LmarLBV1 facilitates parasites’ infectivity in vitro in primary murine macrophages model. The discovery of a virus in L. martiniquensis poses the question of whether it influences pathogenicity of this parasite in vivo, similarly to the LRV in other Leishmania species.

AB - In this work, we describe the first Leishmania-infecting leishbunyavirus—the first virus other than Leishmania RNA virus (LRV) found in trypanosomatid parasites. Its host is Leishmania martiniquensis, a human pathogen causing infections with a wide range of manifestations from asymptomatic to severe visceral disease. This virus (LmarLBV1) possesses many characteristic features of leishbunyaviruses, such as tripartite organization of its RNA genome, with ORFs encoding RNA-dependent RNA polymerase, surface glycoprotein, and nucleoprotein on L, M, and S segments, respectively. Our phylogenetic analyses suggest that LmarLBV1 originated from leishbunyaviruses of monoxenous trypanosomatids and, probably, is a result of genomic re-assortment. The LmarLBV1 facilitates parasites’ infectivity in vitro in primary murine macrophages model. The discovery of a virus in L. martiniquensis poses the question of whether it influences pathogenicity of this parasite in vivo, similarly to the LRV in other Leishmania species.

KW - Bunyavirales

KW - Leishmania martiniquensis

KW - leishbunyavirus

U2 - 10.3390/v12020168

DO - 10.3390/v12020168

M3 - Journal article

VL - 12

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 2

M1 - 168

ER -