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The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction.

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The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction. / Briggs, Laura; McKean, Paul G.; Baines, Andrea et al.
In: Journal of Cell Science, Vol. 117, No. 9, 04.2004, p. 1641-1651.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Briggs, L, McKean, PG, Baines, A, Moreira-Leite, F, Davidge, J, Vaughan, S & Gull, K 2004, 'The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction.', Journal of Cell Science, vol. 117, no. 9, pp. 1641-1651. https://doi.org/10.1242/jcs.00995

APA

Briggs, L., McKean, P. G., Baines, A., Moreira-Leite, F., Davidge, J., Vaughan, S., & Gull, K. (2004). The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction. Journal of Cell Science, 117(9), 1641-1651. https://doi.org/10.1242/jcs.00995

Vancouver

Briggs L, McKean PG, Baines A, Moreira-Leite F, Davidge J, Vaughan S et al. The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction. Journal of Cell Science. 2004 Apr;117(9):1641-1651. doi: 10.1242/jcs.00995

Author

Briggs, Laura ; McKean, Paul G. ; Baines, Andrea et al. / The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction. In: Journal of Cell Science. 2004 ; Vol. 117, No. 9. pp. 1641-1651.

Bibtex

@article{2cb22d016b414e388db0756b9c7e60cd,
title = "The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction.",
abstract = "Throughout its elongation, the new flagellum of the procyclic form of the African trypanosome Trypanosoma brucei is tethered at its tip to the lateral aspect of the old flagellum. This phenomenon provides a cytotactic mechanism for influencing inheritance of cellular pattern. Here, we show that this tethering is produced via a discrete, mobile transmembrane junction – the flagella connector. Light and electron microscopy reveal that the flagella connector links the extending microtubules at the tip of the new flagellum to the lateral aspect of three of the doublet microtubules in the old flagellar axoneme. Two sets of filaments connect the microtubules to three plates on the inner faces of the old and new flagellar membranes. Three differentiated areas of old and new flagellar membranes are then juxtaposed and connected by a central interstitial core of electron-dense material. The flagella connector is formed early in flagellum extension and is removed at the end of cytokinesis, but the exact timing of the latter event is slightly variable. The flagella connector represents a novel form of cellular junction that is both dynamic and mobile.",
keywords = "Trypanosome, Flagellum, Morphogenesis, Cell junction, Flagella connector, Cytotaxis",
author = "Laura Briggs and McKean, {Paul G.} and Andrea Baines and Flavia Moreira-Leite and Jacqueline Davidge and Sue Vaughan and Keith Gull",
year = "2004",
month = apr,
doi = "10.1242/jcs.00995",
language = "English",
volume = "117",
pages = "1641--1651",
journal = "Journal of Cell Science",
issn = "0021-9533",
publisher = "Company of Biologists Ltd",
number = "9",

}

RIS

TY - JOUR

T1 - The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction.

AU - Briggs, Laura

AU - McKean, Paul G.

AU - Baines, Andrea

AU - Moreira-Leite, Flavia

AU - Davidge, Jacqueline

AU - Vaughan, Sue

AU - Gull, Keith

PY - 2004/4

Y1 - 2004/4

N2 - Throughout its elongation, the new flagellum of the procyclic form of the African trypanosome Trypanosoma brucei is tethered at its tip to the lateral aspect of the old flagellum. This phenomenon provides a cytotactic mechanism for influencing inheritance of cellular pattern. Here, we show that this tethering is produced via a discrete, mobile transmembrane junction – the flagella connector. Light and electron microscopy reveal that the flagella connector links the extending microtubules at the tip of the new flagellum to the lateral aspect of three of the doublet microtubules in the old flagellar axoneme. Two sets of filaments connect the microtubules to three plates on the inner faces of the old and new flagellar membranes. Three differentiated areas of old and new flagellar membranes are then juxtaposed and connected by a central interstitial core of electron-dense material. The flagella connector is formed early in flagellum extension and is removed at the end of cytokinesis, but the exact timing of the latter event is slightly variable. The flagella connector represents a novel form of cellular junction that is both dynamic and mobile.

AB - Throughout its elongation, the new flagellum of the procyclic form of the African trypanosome Trypanosoma brucei is tethered at its tip to the lateral aspect of the old flagellum. This phenomenon provides a cytotactic mechanism for influencing inheritance of cellular pattern. Here, we show that this tethering is produced via a discrete, mobile transmembrane junction – the flagella connector. Light and electron microscopy reveal that the flagella connector links the extending microtubules at the tip of the new flagellum to the lateral aspect of three of the doublet microtubules in the old flagellar axoneme. Two sets of filaments connect the microtubules to three plates on the inner faces of the old and new flagellar membranes. Three differentiated areas of old and new flagellar membranes are then juxtaposed and connected by a central interstitial core of electron-dense material. The flagella connector is formed early in flagellum extension and is removed at the end of cytokinesis, but the exact timing of the latter event is slightly variable. The flagella connector represents a novel form of cellular junction that is both dynamic and mobile.

KW - Trypanosome

KW - Flagellum

KW - Morphogenesis

KW - Cell junction

KW - Flagella connector

KW - Cytotaxis

U2 - 10.1242/jcs.00995

DO - 10.1242/jcs.00995

M3 - Journal article

VL - 117

SP - 1641

EP - 1651

JO - Journal of Cell Science

JF - Journal of Cell Science

SN - 0021-9533

IS - 9

ER -