Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed)
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed)
}
TY - CHAP
T1 - The flagellar pocket of trypanosomatids
T2 - a critical feature for cell morphogenesis and pathogenicity
AU - McKean, Paul
AU - Gull, Keith
PY - 2010
Y1 - 2010
N2 - Trypanosomatids possess a highly ordered array of sub-pellicular microtubules that restrict all vesicular traffic to the flagellar pocket (FP); a small invagination of the plasma membrane located at the base of the flagellum. Although the FP is not an adaptation to parasitism per se, it is without question a key pathogenicity feature that has enabled parasitic trypanosomatid species to exploit a diversity of host environments. In this chapter, we focus on the FP of the African trypanosome Trypanosoma brucei and consider recent advances in our understanding of the physical architecture of the FP and the dynamics of FP operation. We conclude with a brief discussion that the trypanosomatid FP represents an example of “extreme biology”, i.e. a normal but exaggerated example of the cell biology present at the flagellum base in proliferating flagellated eukaryotic cells.
AB - Trypanosomatids possess a highly ordered array of sub-pellicular microtubules that restrict all vesicular traffic to the flagellar pocket (FP); a small invagination of the plasma membrane located at the base of the flagellum. Although the FP is not an adaptation to parasitism per se, it is without question a key pathogenicity feature that has enabled parasitic trypanosomatid species to exploit a diversity of host environments. In this chapter, we focus on the FP of the African trypanosome Trypanosoma brucei and consider recent advances in our understanding of the physical architecture of the FP and the dynamics of FP operation. We conclude with a brief discussion that the trypanosomatid FP represents an example of “extreme biology”, i.e. a normal but exaggerated example of the cell biology present at the flagellum base in proliferating flagellated eukaryotic cells.
KW - Trypanosome
KW - Flagellar Pocket
U2 - 10.1007/978-3-642-12863-9_4
DO - 10.1007/978-3-642-12863-9_4
M3 - Chapter (peer-reviewed)
SN - 9783642128622
T3 - Microbiology Monographs
SP - 87
EP - 113
BT - Structures and organelles in pathogenic protists
A2 - de Souza, Wanderley
PB - Springer Verlag
CY - Berlin
ER -