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The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England. / Keeling, Matt J.; Moore, Samuel; Penman, Bridget S. et al.
In: Nature Communications, Vol. 14, No. 1, 740, 10.02.2023.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Keeling, MJ, Moore, S, Penman, BS & Hill, EM 2023, 'The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England', Nature Communications, vol. 14, no. 1, 740. https://doi.org/10.1038/s41467-023-35943-0

APA

Keeling, M. J., Moore, S., Penman, B. S., & Hill, E. M. (2023). The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England. Nature Communications, 14(1), Article 740. https://doi.org/10.1038/s41467-023-35943-0

Vancouver

Keeling MJ, Moore S, Penman BS, Hill EM. The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England. Nature Communications. 2023 Feb 10;14(1):740. doi: 10.1038/s41467-023-35943-0

Author

Keeling, Matt J. ; Moore, Samuel ; Penman, Bridget S. et al. / The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England. In: Nature Communications. 2023 ; Vol. 14, No. 1.

Bibtex

@article{c897845cd03241248e6330b8712b9a25,
title = "The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England",
abstract = "In late 2020, the JCVI (the Joint Committee on Vaccination and Immunisation, which provides advice to the Department of Health and Social Care, England) made two important recommendations for the initial roll-out of the COVID-19 vaccine. The first was that vaccines should be targeted to older and vulnerable people, with the aim of maximally preventing disease rather than infection. The second was to increase the interval between first and second doses from 3 to 12 weeks. Here, we re-examine these recommendations through a mathematical model of SARS-CoV-2 infection in England. We show that targeting the most vulnerable had the biggest immediate impact (compared to targeting younger individuals who may be more responsible for transmission). The 12-week delay was also highly beneficial, estimated to have averted between 32-72 thousand hospital admissions and 4-9 thousand deaths over the first ten months of the campaign (December 2020–September 2021) depending on the assumed interaction between dose interval and efficacy.",
keywords = "Article, /692/699/255/2514, /692/308/174, /631/326/596/4130, /631/326/590, /631/114/2397, article",
author = "Keeling, {Matt J.} and Samuel Moore and Penman, {Bridget S.} and Hill, {Edward M.}",
year = "2023",
month = feb,
day = "10",
doi = "10.1038/s41467-023-35943-0",
language = "English",
volume = "14",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England

AU - Keeling, Matt J.

AU - Moore, Samuel

AU - Penman, Bridget S.

AU - Hill, Edward M.

PY - 2023/2/10

Y1 - 2023/2/10

N2 - In late 2020, the JCVI (the Joint Committee on Vaccination and Immunisation, which provides advice to the Department of Health and Social Care, England) made two important recommendations for the initial roll-out of the COVID-19 vaccine. The first was that vaccines should be targeted to older and vulnerable people, with the aim of maximally preventing disease rather than infection. The second was to increase the interval between first and second doses from 3 to 12 weeks. Here, we re-examine these recommendations through a mathematical model of SARS-CoV-2 infection in England. We show that targeting the most vulnerable had the biggest immediate impact (compared to targeting younger individuals who may be more responsible for transmission). The 12-week delay was also highly beneficial, estimated to have averted between 32-72 thousand hospital admissions and 4-9 thousand deaths over the first ten months of the campaign (December 2020–September 2021) depending on the assumed interaction between dose interval and efficacy.

AB - In late 2020, the JCVI (the Joint Committee on Vaccination and Immunisation, which provides advice to the Department of Health and Social Care, England) made two important recommendations for the initial roll-out of the COVID-19 vaccine. The first was that vaccines should be targeted to older and vulnerable people, with the aim of maximally preventing disease rather than infection. The second was to increase the interval between first and second doses from 3 to 12 weeks. Here, we re-examine these recommendations through a mathematical model of SARS-CoV-2 infection in England. We show that targeting the most vulnerable had the biggest immediate impact (compared to targeting younger individuals who may be more responsible for transmission). The 12-week delay was also highly beneficial, estimated to have averted between 32-72 thousand hospital admissions and 4-9 thousand deaths over the first ten months of the campaign (December 2020–September 2021) depending on the assumed interaction between dose interval and efficacy.

KW - Article

KW - /692/699/255/2514

KW - /692/308/174

KW - /631/326/596/4130

KW - /631/326/590

KW - /631/114/2397

KW - article

U2 - 10.1038/s41467-023-35943-0

DO - 10.1038/s41467-023-35943-0

M3 - Journal article

VL - 14

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 740

ER -