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The interferon response to intracellular DNA: why so many receptors?

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The interferon response to intracellular DNA : why so many receptors? / Unterholzner, Leonie.

In: Immunobiology, Vol. 218, No. 11, 11.2013, p. 1312-1321.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Unterholzner, Leonie. / The interferon response to intracellular DNA : why so many receptors?. In: Immunobiology. 2013 ; Vol. 218, No. 11. pp. 1312-1321.

Bibtex

@article{323943d6b3634e7d8917f819fc393701,
title = "The interferon response to intracellular DNA: why so many receptors?",
abstract = "The detection of intracellular DNA has emerged to be a key event in the innate immune response to viruses and intracellular bacteria, and during conditions of sterile inflammation and autoimmunity. One of the consequences of the detection of DNA as a 'stranger' and a 'danger' signal is the production of type I interferons and pro-inflammatory cytokines. Much work has been dedicated to the elucidation of the signalling cascades that activate this DNA-induced gene expression programme. However, while many proteins have been proposed to act as sensors for intracellular DNA in recent years, none has been met with universal acceptance, and a theory linking all the recent observations is, as yet, lacking. This review presents the evidence for the various interferon-inducing DNA receptors proposed to date, and examines the hypotheses that might explain why so many different receptors appear to be involved in the innate immune recognition of intracellular DNA.",
keywords = "Animals, Autoimmunity, DNA, Gene Expression, Humans, Immunity, Innate, Inflammation, Interferon Type I, Receptors, Cell Surface, Virus Diseases",
author = "Leonie Unterholzner",
note = "Copyright {\textcopyright} 2013 Elsevier GmbH. All rights reserved.",
year = "2013",
month = nov,
doi = "10.1016/j.imbio.2013.07.007",
language = "English",
volume = "218",
pages = "1312--1321",
journal = "Immunobiology",
issn = "0171-2985",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
number = "11",

}

RIS

TY - JOUR

T1 - The interferon response to intracellular DNA

T2 - why so many receptors?

AU - Unterholzner, Leonie

N1 - Copyright © 2013 Elsevier GmbH. All rights reserved.

PY - 2013/11

Y1 - 2013/11

N2 - The detection of intracellular DNA has emerged to be a key event in the innate immune response to viruses and intracellular bacteria, and during conditions of sterile inflammation and autoimmunity. One of the consequences of the detection of DNA as a 'stranger' and a 'danger' signal is the production of type I interferons and pro-inflammatory cytokines. Much work has been dedicated to the elucidation of the signalling cascades that activate this DNA-induced gene expression programme. However, while many proteins have been proposed to act as sensors for intracellular DNA in recent years, none has been met with universal acceptance, and a theory linking all the recent observations is, as yet, lacking. This review presents the evidence for the various interferon-inducing DNA receptors proposed to date, and examines the hypotheses that might explain why so many different receptors appear to be involved in the innate immune recognition of intracellular DNA.

AB - The detection of intracellular DNA has emerged to be a key event in the innate immune response to viruses and intracellular bacteria, and during conditions of sterile inflammation and autoimmunity. One of the consequences of the detection of DNA as a 'stranger' and a 'danger' signal is the production of type I interferons and pro-inflammatory cytokines. Much work has been dedicated to the elucidation of the signalling cascades that activate this DNA-induced gene expression programme. However, while many proteins have been proposed to act as sensors for intracellular DNA in recent years, none has been met with universal acceptance, and a theory linking all the recent observations is, as yet, lacking. This review presents the evidence for the various interferon-inducing DNA receptors proposed to date, and examines the hypotheses that might explain why so many different receptors appear to be involved in the innate immune recognition of intracellular DNA.

KW - Animals

KW - Autoimmunity

KW - DNA

KW - Gene Expression

KW - Humans

KW - Immunity, Innate

KW - Inflammation

KW - Interferon Type I

KW - Receptors, Cell Surface

KW - Virus Diseases

U2 - 10.1016/j.imbio.2013.07.007

DO - 10.1016/j.imbio.2013.07.007

M3 - Journal article

C2 - 23962476

VL - 218

SP - 1312

EP - 1321

JO - Immunobiology

JF - Immunobiology

SN - 0171-2985

IS - 11

ER -