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The isolation and amino acid composition of senile plaque core protein

Research output: Contribution to journalJournal articlepeer-review

<mark>Journal publication date</mark>1983
<mark>Journal</mark>Experimental Brain Research
Issue number2
Number of pages5
Pages (from-to)348-52
Publication StatusPublished
<mark>Original language</mark>English


A new method has been developed for the isolation of intact senile (neuritic) plaque cores from post-mortem brains of patients with Alzheimer's disease. The plaque cores were found to be insoluble in various protein denaturants. The amino acid composition of the plaque core protein does not resemble that of any known form of amyloid.