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The Kinetics of β-Hematin Crystallization Measured by Depolarized Light Scattering

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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The Kinetics of β-Hematin Crystallization Measured by Depolarized Light Scattering. / Rifaie-Graham, Omar; Hua, Xiao; Bruns, Nico et al.
In: Small, Vol. 14, No. 46, 1802295, 15.11.2018.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Rifaie-Graham, O, Hua, X, Bruns, N & Balog, S 2018, 'The Kinetics of β-Hematin Crystallization Measured by Depolarized Light Scattering', Small, vol. 14, no. 46, 1802295. https://doi.org/10.1002/smll.201802295

APA

Rifaie-Graham, O., Hua, X., Bruns, N., & Balog, S. (2018). The Kinetics of β-Hematin Crystallization Measured by Depolarized Light Scattering. Small, 14(46), Article 1802295. https://doi.org/10.1002/smll.201802295

Vancouver

Rifaie-Graham O, Hua X, Bruns N, Balog S. The Kinetics of β-Hematin Crystallization Measured by Depolarized Light Scattering. Small. 2018 Nov 15;14(46):1802295. Epub 2018 Sept 3. doi: 10.1002/smll.201802295

Author

Rifaie-Graham, Omar ; Hua, Xiao ; Bruns, Nico et al. / The Kinetics of β-Hematin Crystallization Measured by Depolarized Light Scattering. In: Small. 2018 ; Vol. 14, No. 46.

Bibtex

@article{8ced108980184f1e921af5ad90200b00,
title = "The Kinetics of β-Hematin Crystallization Measured by Depolarized Light Scattering",
abstract = "Malaria is caused by Plasmodium sp. parasites transmitted by infected female Anopheles sp. mosquitoes. The survival of the parasites in the host relies on detoxifying free heme by biocrystallization into insoluble crystals called hemozoin. This mechanism of self-preservation is targeted by a certain class of antimalarial drugs, which are screened and selected based on their capacity to inhibit the formation of hemozoin crystals. Therefore, experimental techniques capable of accurately characterizing the kinetics of crystal formation are valuable. Relying on the optical anisotropy of hemozoin, the kinetics of β-hematin crystal formation through the statistical analysis of photon counts of dynamic depolarized light scattering (DDLS), in the absence and presence of an antimalarial drug (chloroquine, CQ), is described. It is found that CQ has an impact on both the nucleation and growth of the crystals.",
author = "Omar Rifaie-Graham and Xiao Hua and Nico Bruns and Sandor Balog",
year = "2018",
month = nov,
day = "15",
doi = "10.1002/smll.201802295",
language = "English",
volume = "14",
journal = "Small",
issn = "1613-6810",
publisher = "Wiley-VCH Verlag",
number = "46",

}

RIS

TY - JOUR

T1 - The Kinetics of β-Hematin Crystallization Measured by Depolarized Light Scattering

AU - Rifaie-Graham, Omar

AU - Hua, Xiao

AU - Bruns, Nico

AU - Balog, Sandor

PY - 2018/11/15

Y1 - 2018/11/15

N2 - Malaria is caused by Plasmodium sp. parasites transmitted by infected female Anopheles sp. mosquitoes. The survival of the parasites in the host relies on detoxifying free heme by biocrystallization into insoluble crystals called hemozoin. This mechanism of self-preservation is targeted by a certain class of antimalarial drugs, which are screened and selected based on their capacity to inhibit the formation of hemozoin crystals. Therefore, experimental techniques capable of accurately characterizing the kinetics of crystal formation are valuable. Relying on the optical anisotropy of hemozoin, the kinetics of β-hematin crystal formation through the statistical analysis of photon counts of dynamic depolarized light scattering (DDLS), in the absence and presence of an antimalarial drug (chloroquine, CQ), is described. It is found that CQ has an impact on both the nucleation and growth of the crystals.

AB - Malaria is caused by Plasmodium sp. parasites transmitted by infected female Anopheles sp. mosquitoes. The survival of the parasites in the host relies on detoxifying free heme by biocrystallization into insoluble crystals called hemozoin. This mechanism of self-preservation is targeted by a certain class of antimalarial drugs, which are screened and selected based on their capacity to inhibit the formation of hemozoin crystals. Therefore, experimental techniques capable of accurately characterizing the kinetics of crystal formation are valuable. Relying on the optical anisotropy of hemozoin, the kinetics of β-hematin crystal formation through the statistical analysis of photon counts of dynamic depolarized light scattering (DDLS), in the absence and presence of an antimalarial drug (chloroquine, CQ), is described. It is found that CQ has an impact on both the nucleation and growth of the crystals.

U2 - 10.1002/smll.201802295

DO - 10.1002/smll.201802295

M3 - Journal article

VL - 14

JO - Small

JF - Small

SN - 1613-6810

IS - 46

M1 - 1802295

ER -