Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - The melanocyte lineage in development and disease
AU - Mort, Richard L.
AU - Jackson, Ian J.
AU - Patton, E. Elizabeth
N1 - © 2015. Published by The Company of Biologists Ltd.
PY - 2015/2/15
Y1 - 2015/2/15
N2 - Melanocyte development provides an excellent model for studying more complex developmental processes. Melanocytes have an apparently simple aetiology, differentiating from the neural crest and migrating through the developing embryo to specific locations within the skin and hair follicles, and to other sites in the body. The study of pigmentation mutations in the mouse provided the initial key to identifying the genes and proteins involved in melanocyte development. In addition, work on chicken has provided important embryological and molecular insights, whereas studies in zebrafish have allowed live imaging as well as genetic and transgenic approaches. This cross-species approach is powerful and, as we review here, has resulted in a detailed understanding of melanocyte development and differentiation, melanocyte stem cells and the role of the melanocyte lineage in diseases such as melanoma.
AB - Melanocyte development provides an excellent model for studying more complex developmental processes. Melanocytes have an apparently simple aetiology, differentiating from the neural crest and migrating through the developing embryo to specific locations within the skin and hair follicles, and to other sites in the body. The study of pigmentation mutations in the mouse provided the initial key to identifying the genes and proteins involved in melanocyte development. In addition, work on chicken has provided important embryological and molecular insights, whereas studies in zebrafish have allowed live imaging as well as genetic and transgenic approaches. This cross-species approach is powerful and, as we review here, has resulted in a detailed understanding of melanocyte development and differentiation, melanocyte stem cells and the role of the melanocyte lineage in diseases such as melanoma.
KW - Animals
KW - Humans
KW - Melanocytes
KW - Melanoma
KW - Microphthalmia-Associated Transcription Factor
KW - Neural Crest
KW - Stem Cells
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.1242/dev.106567
DO - 10.1242/dev.106567
M3 - Journal article
C2 - 25670789
VL - 142
SP - 620
EP - 632
JO - Development
JF - Development
SN - 0950-1991
IS - 4
ER -