Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - The nature and dissemination of UHMWPE wear debris retrieved from periprosthetic tissue of THR.
AU - Elfick, Alistair P. D.
AU - Green, Sarah M.
AU - Krikler, Steve
AU - Unsworth, Anthony
PY - 2003/4/1
Y1 - 2003/4/1
N2 - The role of wear debris in provoking joint replacement failure through bone resorption is now supported by much research. This study presents the analysis of 104 tissue samples using laser diffraction wear particle analysis in conjunction with standard histologic methods. The number and volume distributions were correlated to a range of joint and patient parameters. The median particle diameter by number was 0.69 μm. No particles smaller than 0.113 μm were resolved. No variation in terms of particle distribution was found among joint types. The ability of particles to migrate away from their point of origin was found to be inversely proportional to their size. The numbers of particles per gram of tissue found in various regions around the prosthesis varied little. Further, the numbers of particles in tissue samples shown to have a chronic foreign-body reaction was > 1 × 109 particles/gram.
AB - The role of wear debris in provoking joint replacement failure through bone resorption is now supported by much research. This study presents the analysis of 104 tissue samples using laser diffraction wear particle analysis in conjunction with standard histologic methods. The number and volume distributions were correlated to a range of joint and patient parameters. The median particle diameter by number was 0.69 μm. No particles smaller than 0.113 μm were resolved. No variation in terms of particle distribution was found among joint types. The ability of particles to migrate away from their point of origin was found to be inversely proportional to their size. The numbers of particles per gram of tissue found in various regions around the prosthesis varied little. Further, the numbers of particles in tissue samples shown to have a chronic foreign-body reaction was > 1 × 109 particles/gram.
KW - THR
KW - prosthetic wear debris
KW - UHMWPE
KW - explanted
KW - dissemination
U2 - 10.1002/jbm.a.10455
DO - 10.1002/jbm.a.10455
M3 - Journal article
VL - 65
SP - 95
EP - 108
JO - Journal of Biomedical Materials Research Part A
JF - Journal of Biomedical Materials Research Part A
SN - 1549-3296
IS - 1
ER -