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The occult aftermath of boxing

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The occult aftermath of boxing. / Roberts, G W; Allsop, D; Bruton, C.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 53, No. 5, 05.1990, p. 373-378.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Roberts, GW, Allsop, D & Bruton, C 1990, 'The occult aftermath of boxing', Journal of Neurology, Neurosurgery and Psychiatry, vol. 53, no. 5, pp. 373-378. https://doi.org/10.1136/jnnp.53.5.373

APA

Roberts, G. W., Allsop, D., & Bruton, C. (1990). The occult aftermath of boxing. Journal of Neurology, Neurosurgery and Psychiatry, 53(5), 373-378. https://doi.org/10.1136/jnnp.53.5.373

Vancouver

Roberts GW, Allsop D, Bruton C. The occult aftermath of boxing. Journal of Neurology, Neurosurgery and Psychiatry. 1990 May;53(5):373-378. https://doi.org/10.1136/jnnp.53.5.373

Author

Roberts, G W ; Allsop, D ; Bruton, C. / The occult aftermath of boxing. In: Journal of Neurology, Neurosurgery and Psychiatry. 1990 ; Vol. 53, No. 5. pp. 373-378.

Bibtex

@article{ac6cbdfa0fd545ffbd80e9ace43fedcf,
title = "The occult aftermath of boxing",
abstract = "The repeated head trauma experienced by boxers can lead to the development of dementia pugilistica (DP)--punch drunk syndrome. The neuropathology of DP in a classic report by Corsellis et al describes the presence of numerous neurofibrillary tangles in the absence of plaques, in contrast to the profusion of tangles and plaques seen in Alzheimer's disease (AD). The DP cases used in that report were re-investigated with immunocytochemical methods and an antibody raised to the beta-protein present in AD plaques. We found that all DP cases with substantial tangle formation showed evidence of extensive beta-protein immunoreactive deposits (plaques). These diffuse {"}plaques{"} were not visible with Congo-red or standard silver stains. The degree of beta-protein deposition was comparable to that seen in AD. Our data indicate that the present neuropathological description of DP (tangles but no plaques) should be altered to acknowledge the presence of substantial beta-protein deposition (plaques). The molecular markers present in the plaques and tangles of DP are the same as those in AD. Similarities in clinical symptoms, distribution of pathology and neurochemical deficits also exist. Epidemiological studies have shown that head injury is a risk factor in AD. It is probable that DP and AD share common pathogenic mechanisms leading to tangle and plaque formation.",
keywords = "Adult, Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Amyloid beta-Peptides, Boxing, Brain, Brain Concussion, Brain Damage, Chronic, Dementia, Follow-Up Studies, Humans, Immunoenzyme Techniques, Male, Middle Aged, Neurofibrils",
author = "Roberts, {G W} and D Allsop and C Bruton",
year = "1990",
month = may,
doi = "10.1136/jnnp.53.5.373",
language = "English",
volume = "53",
pages = "373--378",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - The occult aftermath of boxing

AU - Roberts, G W

AU - Allsop, D

AU - Bruton, C

PY - 1990/5

Y1 - 1990/5

N2 - The repeated head trauma experienced by boxers can lead to the development of dementia pugilistica (DP)--punch drunk syndrome. The neuropathology of DP in a classic report by Corsellis et al describes the presence of numerous neurofibrillary tangles in the absence of plaques, in contrast to the profusion of tangles and plaques seen in Alzheimer's disease (AD). The DP cases used in that report were re-investigated with immunocytochemical methods and an antibody raised to the beta-protein present in AD plaques. We found that all DP cases with substantial tangle formation showed evidence of extensive beta-protein immunoreactive deposits (plaques). These diffuse "plaques" were not visible with Congo-red or standard silver stains. The degree of beta-protein deposition was comparable to that seen in AD. Our data indicate that the present neuropathological description of DP (tangles but no plaques) should be altered to acknowledge the presence of substantial beta-protein deposition (plaques). The molecular markers present in the plaques and tangles of DP are the same as those in AD. Similarities in clinical symptoms, distribution of pathology and neurochemical deficits also exist. Epidemiological studies have shown that head injury is a risk factor in AD. It is probable that DP and AD share common pathogenic mechanisms leading to tangle and plaque formation.

AB - The repeated head trauma experienced by boxers can lead to the development of dementia pugilistica (DP)--punch drunk syndrome. The neuropathology of DP in a classic report by Corsellis et al describes the presence of numerous neurofibrillary tangles in the absence of plaques, in contrast to the profusion of tangles and plaques seen in Alzheimer's disease (AD). The DP cases used in that report were re-investigated with immunocytochemical methods and an antibody raised to the beta-protein present in AD plaques. We found that all DP cases with substantial tangle formation showed evidence of extensive beta-protein immunoreactive deposits (plaques). These diffuse "plaques" were not visible with Congo-red or standard silver stains. The degree of beta-protein deposition was comparable to that seen in AD. Our data indicate that the present neuropathological description of DP (tangles but no plaques) should be altered to acknowledge the presence of substantial beta-protein deposition (plaques). The molecular markers present in the plaques and tangles of DP are the same as those in AD. Similarities in clinical symptoms, distribution of pathology and neurochemical deficits also exist. Epidemiological studies have shown that head injury is a risk factor in AD. It is probable that DP and AD share common pathogenic mechanisms leading to tangle and plaque formation.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease

KW - Amyloid

KW - Amyloid beta-Peptides

KW - Boxing

KW - Brain

KW - Brain Concussion

KW - Brain Damage, Chronic

KW - Dementia

KW - Follow-Up Studies

KW - Humans

KW - Immunoenzyme Techniques

KW - Male

KW - Middle Aged

KW - Neurofibrils

U2 - 10.1136/jnnp.53.5.373

DO - 10.1136/jnnp.53.5.373

M3 - Journal article

C2 - 2191084

VL - 53

SP - 373

EP - 378

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 5

ER -