In this paper, the most recent writings by Giorgio Agamben and Bruno Latour are brought into dialog by examining what light they shed on contemporary debates concerning “end of life” decisions. More specifically, the paper focuses on the debates sparked by Diane Pretty's request for a grant of immunity against legal prosecution if her husband were to assist her to commit suicide and so terminate her increasingly unbearable suffering from motor neurone disease. The aim of this exercise is to articulate the presuppositions informing two influential and radically opposed views on the contemporary reconfiguration of relationships between humans, animals and other non-humans.