Research output: Contribution to Journal/Magazine › Journal article › peer-review
<mark>Journal publication date</mark> | 08/2005 |
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<mark>Journal</mark> | Biochemical Society Transactions |
Issue number | 4 |
Volume | 33 |
Number of pages | 3 |
Pages (from-to) | 548-550 |
Publication Status | Published |
<mark>Original language</mark> | English |
By means of an ESR spin-trapping method, we have shown that A beta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.