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The relationship between eye movement and brain structural abnormalities in patients with schizophrenia and their unaffected relatives.

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The relationship between eye movement and brain structural abnormalities in patients with schizophrenia and their unaffected relatives. / Schulze, Katja; MacCabe, James H.; Rabe-Hesketh, Sophia; Crawford, Trevor; Marshall, Nicolette; Zanelli, Jolanta; Walshe, Muriel; Bramon, Elvira; Murray, Robin M.; McDonald, Colm.

In: Journal of Psychiatric Research, Vol. 40, No. 7, 10.2006, p. 589-598.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Schulze, K, MacCabe, JH, Rabe-Hesketh, S, Crawford, T, Marshall, N, Zanelli, J, Walshe, M, Bramon, E, Murray, RM & McDonald, C 2006, 'The relationship between eye movement and brain structural abnormalities in patients with schizophrenia and their unaffected relatives.', Journal of Psychiatric Research, vol. 40, no. 7, pp. 589-598. https://doi.org/10.1016/j.jpsychires.2005.05.003

APA

Schulze, K., MacCabe, J. H., Rabe-Hesketh, S., Crawford, T., Marshall, N., Zanelli, J., Walshe, M., Bramon, E., Murray, R. M., & McDonald, C. (2006). The relationship between eye movement and brain structural abnormalities in patients with schizophrenia and their unaffected relatives. Journal of Psychiatric Research, 40(7), 589-598. https://doi.org/10.1016/j.jpsychires.2005.05.003

Vancouver

Author

Schulze, Katja ; MacCabe, James H. ; Rabe-Hesketh, Sophia ; Crawford, Trevor ; Marshall, Nicolette ; Zanelli, Jolanta ; Walshe, Muriel ; Bramon, Elvira ; Murray, Robin M. ; McDonald, Colm. / The relationship between eye movement and brain structural abnormalities in patients with schizophrenia and their unaffected relatives. In: Journal of Psychiatric Research. 2006 ; Vol. 40, No. 7. pp. 589-598.

Bibtex

@article{d6a554e6330c45f7b6a257ca28436ad4,
title = "The relationship between eye movement and brain structural abnormalities in patients with schizophrenia and their unaffected relatives.",
abstract = "Schizophrenia is associated with subtle eye movement and brain structural abnormalities, but the extent to which these abnormalities occur in the same individuals is unclear. The relationship between quantitative measures of eye movement task performance (smooth pursuit and antisaccade) and MRI volumetric measurements (whole brain volume, prefrontal region, lateral ventricles, third ventricle, hippocampus, and cerebellum) was assessed in 70 patients with schizophrenia or schizoaffective disorder, 105 of their unaffected first-degree relatives and 68 controls. There was a lack of correlation between eye movement and morphometric abnormalities suggesting largely separable neurobiological pathways underlying the morphological and the eye movement deviations that have previously been identified in these patients. However, in the total sample, smaller prefrontal lobe volume was significantly associated with longer latency of correct antisaccades (partial correlation r = −0.22, p = 0.01) in line with previous studies demonstrating the importance of frontal lobe structures in performance of the antisaccade task. Also larger third ventricular volume was associated with larger mean amplitude of intrusive saccades during smooth pursuit (r = 0.28, p = 0.01). There were no significant between-group differences in the relationship between measures of eye movement and morphometry.",
keywords = "Schizophrenia, MRI, Smooth pursuit, Antisaccade, Endophenotype, Family study",
author = "Katja Schulze and MacCabe, {James H.} and Sophia Rabe-Hesketh and Trevor Crawford and Nicolette Marshall and Jolanta Zanelli and Muriel Walshe and Elvira Bramon and Murray, {Robin M.} and Colm McDonald",
year = "2006",
month = oct,
doi = "10.1016/j.jpsychires.2005.05.003",
language = "English",
volume = "40",
pages = "589--598",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",
number = "7",

}

RIS

TY - JOUR

T1 - The relationship between eye movement and brain structural abnormalities in patients with schizophrenia and their unaffected relatives.

AU - Schulze, Katja

AU - MacCabe, James H.

AU - Rabe-Hesketh, Sophia

AU - Crawford, Trevor

AU - Marshall, Nicolette

AU - Zanelli, Jolanta

AU - Walshe, Muriel

AU - Bramon, Elvira

AU - Murray, Robin M.

AU - McDonald, Colm

PY - 2006/10

Y1 - 2006/10

N2 - Schizophrenia is associated with subtle eye movement and brain structural abnormalities, but the extent to which these abnormalities occur in the same individuals is unclear. The relationship between quantitative measures of eye movement task performance (smooth pursuit and antisaccade) and MRI volumetric measurements (whole brain volume, prefrontal region, lateral ventricles, third ventricle, hippocampus, and cerebellum) was assessed in 70 patients with schizophrenia or schizoaffective disorder, 105 of their unaffected first-degree relatives and 68 controls. There was a lack of correlation between eye movement and morphometric abnormalities suggesting largely separable neurobiological pathways underlying the morphological and the eye movement deviations that have previously been identified in these patients. However, in the total sample, smaller prefrontal lobe volume was significantly associated with longer latency of correct antisaccades (partial correlation r = −0.22, p = 0.01) in line with previous studies demonstrating the importance of frontal lobe structures in performance of the antisaccade task. Also larger third ventricular volume was associated with larger mean amplitude of intrusive saccades during smooth pursuit (r = 0.28, p = 0.01). There were no significant between-group differences in the relationship between measures of eye movement and morphometry.

AB - Schizophrenia is associated with subtle eye movement and brain structural abnormalities, but the extent to which these abnormalities occur in the same individuals is unclear. The relationship between quantitative measures of eye movement task performance (smooth pursuit and antisaccade) and MRI volumetric measurements (whole brain volume, prefrontal region, lateral ventricles, third ventricle, hippocampus, and cerebellum) was assessed in 70 patients with schizophrenia or schizoaffective disorder, 105 of their unaffected first-degree relatives and 68 controls. There was a lack of correlation between eye movement and morphometric abnormalities suggesting largely separable neurobiological pathways underlying the morphological and the eye movement deviations that have previously been identified in these patients. However, in the total sample, smaller prefrontal lobe volume was significantly associated with longer latency of correct antisaccades (partial correlation r = −0.22, p = 0.01) in line with previous studies demonstrating the importance of frontal lobe structures in performance of the antisaccade task. Also larger third ventricular volume was associated with larger mean amplitude of intrusive saccades during smooth pursuit (r = 0.28, p = 0.01). There were no significant between-group differences in the relationship between measures of eye movement and morphometry.

KW - Schizophrenia

KW - MRI

KW - Smooth pursuit

KW - Antisaccade

KW - Endophenotype

KW - Family study

U2 - 10.1016/j.jpsychires.2005.05.003

DO - 10.1016/j.jpsychires.2005.05.003

M3 - Journal article

VL - 40

SP - 589

EP - 598

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 7

ER -