Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - The relationship between eye movement and brain structural abnormalities in patients with schizophrenia and their unaffected relatives.
AU - Schulze, Katja
AU - MacCabe, James H.
AU - Rabe-Hesketh, Sophia
AU - Crawford, Trevor
AU - Marshall, Nicolette
AU - Zanelli, Jolanta
AU - Walshe, Muriel
AU - Bramon, Elvira
AU - Murray, Robin M.
AU - McDonald, Colm
PY - 2006/10
Y1 - 2006/10
N2 - Schizophrenia is associated with subtle eye movement and brain structural abnormalities, but the extent to which these abnormalities occur in the same individuals is unclear. The relationship between quantitative measures of eye movement task performance (smooth pursuit and antisaccade) and MRI volumetric measurements (whole brain volume, prefrontal region, lateral ventricles, third ventricle, hippocampus, and cerebellum) was assessed in 70 patients with schizophrenia or schizoaffective disorder, 105 of their unaffected first-degree relatives and 68 controls. There was a lack of correlation between eye movement and morphometric abnormalities suggesting largely separable neurobiological pathways underlying the morphological and the eye movement deviations that have previously been identified in these patients. However, in the total sample, smaller prefrontal lobe volume was significantly associated with longer latency of correct antisaccades (partial correlation r = −0.22, p = 0.01) in line with previous studies demonstrating the importance of frontal lobe structures in performance of the antisaccade task. Also larger third ventricular volume was associated with larger mean amplitude of intrusive saccades during smooth pursuit (r = 0.28, p = 0.01). There were no significant between-group differences in the relationship between measures of eye movement and morphometry.
AB - Schizophrenia is associated with subtle eye movement and brain structural abnormalities, but the extent to which these abnormalities occur in the same individuals is unclear. The relationship between quantitative measures of eye movement task performance (smooth pursuit and antisaccade) and MRI volumetric measurements (whole brain volume, prefrontal region, lateral ventricles, third ventricle, hippocampus, and cerebellum) was assessed in 70 patients with schizophrenia or schizoaffective disorder, 105 of their unaffected first-degree relatives and 68 controls. There was a lack of correlation between eye movement and morphometric abnormalities suggesting largely separable neurobiological pathways underlying the morphological and the eye movement deviations that have previously been identified in these patients. However, in the total sample, smaller prefrontal lobe volume was significantly associated with longer latency of correct antisaccades (partial correlation r = −0.22, p = 0.01) in line with previous studies demonstrating the importance of frontal lobe structures in performance of the antisaccade task. Also larger third ventricular volume was associated with larger mean amplitude of intrusive saccades during smooth pursuit (r = 0.28, p = 0.01). There were no significant between-group differences in the relationship between measures of eye movement and morphometry.
KW - Schizophrenia
KW - MRI
KW - Smooth pursuit
KW - Antisaccade
KW - Endophenotype
KW - Family study
U2 - 10.1016/j.jpsychires.2005.05.003
DO - 10.1016/j.jpsychires.2005.05.003
M3 - Journal article
VL - 40
SP - 589
EP - 598
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 7
ER -