TY - JOUR

T1 - The Relationship between Organ Damage and Quality of Life in Portuguese Patients with Systemic Lupus Erythematosus

AU - Lourenco, F.

AU - Moura, A.

AU - Ferreira, L.

AU - Caixeiro Mateus, Ceu

AU - Moraes-Fontes, M. F.

PY - 2015

Y1 - 2015

N2 - Introduction. Functional status, as assessed by health-related Quality of Life(HRQoL) instruments, is an important outcome measure in quality of care ofSystemic Lupus Erythematosus (SLE) patients, increasingly recognised alongsideimprovement in survival and a need for humanistic and economic studies.Notwithstanding its importance, this is one of the few Portuguese studies thataim to understand the relationship between HRQoL measured by SF-36v2 andEQ-5D-3L and damage accrual.Methods. The study was prospectively conducted in patients fulfilling the revised1997 ACR SLE criteria, consecutively enrolled during routine clinical assessment.Age, gender, disease number/type of ACR criteria and organ damage(SLICC/DI) were recorded. Self-reported SF-36 and EQ-5D-3L Portuguese versions of questionnaires were sent by mail. Patient participation was voluntary,informed and confidential.Results. The 43 respondents were predominantly female (95%). Mean age anddisease duration were 49±15 and 10±6 years, respectively, with mean ACR criteria of 6±1. Damage occurred in 19 patients (43%), mean SLICC index 1.6±1.Overall, SF-36 reported consistently lower values in all dimensions when compared to the Portuguese population. Average values for physical and mentalcomponent summaries of SF-36 were 42.41±12.6 and 45.21±12.5, respectively.EQ-5D-3L mean was 0.64±0.2. There was no correlation between any of the QoLindices and degree of damage accrual.Conclusion. As expected with chronic illnesses, SLE results in reduced QoL regardless of the measure used. As previously reported, HRQoL measures seem to complement rather than correlate with permanent disease damage in SLE.

AB - Introduction. Functional status, as assessed by health-related Quality of Life(HRQoL) instruments, is an important outcome measure in quality of care ofSystemic Lupus Erythematosus (SLE) patients, increasingly recognised alongsideimprovement in survival and a need for humanistic and economic studies.Notwithstanding its importance, this is one of the few Portuguese studies thataim to understand the relationship between HRQoL measured by SF-36v2 andEQ-5D-3L and damage accrual.Methods. The study was prospectively conducted in patients fulfilling the revised1997 ACR SLE criteria, consecutively enrolled during routine clinical assessment.Age, gender, disease number/type of ACR criteria and organ damage(SLICC/DI) were recorded. Self-reported SF-36 and EQ-5D-3L Portuguese versions of questionnaires were sent by mail. Patient participation was voluntary,informed and confidential.Results. The 43 respondents were predominantly female (95%). Mean age anddisease duration were 49±15 and 10±6 years, respectively, with mean ACR criteria of 6±1. Damage occurred in 19 patients (43%), mean SLICC index 1.6±1.Overall, SF-36 reported consistently lower values in all dimensions when compared to the Portuguese population. Average values for physical and mentalcomponent summaries of SF-36 were 42.41±12.6 and 45.21±12.5, respectively.EQ-5D-3L mean was 0.64±0.2. There was no correlation between any of the QoLindices and degree of damage accrual.Conclusion. As expected with chronic illnesses, SLE results in reduced QoL regardless of the measure used. As previously reported, HRQoL measures seem to complement rather than correlate with permanent disease damage in SLE.

M3 - Meeting abstract

VL - 33

SP - S55-S55

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

IS - 3

ER -