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The role of brain gaseous neurotransmitters in anxiety

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The role of brain gaseous neurotransmitters in anxiety. / Pałasz, A.; Menezes, I.C.; Worthington, J.J.

In: Pharmacological reports : PR, Vol. 73, 13.03.2021, p. 357–371.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Pałasz, A, Menezes, IC & Worthington, JJ 2021, 'The role of brain gaseous neurotransmitters in anxiety', Pharmacological reports : PR, vol. 73, pp. 357–371. https://doi.org/10.1007/s43440-021-00242-2

APA

Pałasz, A., Menezes, I. C., & Worthington, J. J. (2021). The role of brain gaseous neurotransmitters in anxiety. Pharmacological reports : PR, 73, 357–371. https://doi.org/10.1007/s43440-021-00242-2

Vancouver

Pałasz A, Menezes IC, Worthington JJ. The role of brain gaseous neurotransmitters in anxiety. Pharmacological reports : PR. 2021 Mar 13;73:357–371. https://doi.org/10.1007/s43440-021-00242-2

Author

Pałasz, A. ; Menezes, I.C. ; Worthington, J.J. / The role of brain gaseous neurotransmitters in anxiety. In: Pharmacological reports : PR. 2021 ; Vol. 73. pp. 357–371.

Bibtex

@article{45bc78e6308741a79136023be9199ad9,
title = "The role of brain gaseous neurotransmitters in anxiety",
abstract = "Although anxiety is perhaps one of the most significant current medical and social problems, the neurochemical mechanistic background of this common condition remains to be fully understood. Multifunctional regulatory gasotransmitters are novel, atypical inorganic factors of the brain that are involved in the mechanisms of anxiety responses. Nitric oxide (NO) signaling shows ambiguous action in animal models of anxiety, while NO donors exert anxiogenic or anxiolytic effect depending on their chemical structure, dose, treatment schedule and gas release rapidity. The majority of NO synthase inhibitors act as a relatively potent axiolytic agents, while hydrogen sulfide (H2S) and carbon monoxide (CO) delivered experimentally in the form of “slow” or “fast” releasing donors have recently been considered as anxiolytic neurotransmitters. In this comprehensive review we critically summarize the literature regarding the intriguing roles of NO, H2S and CO in the neuromolecular mechanisms of anxiety in the context of their putative, yet promising therapeutic application. A possible mechanism of gasotransmitter action at the level of anxiety-related synaptic transmission is also presented. Brain gasesous neuromediators urgently require further wide ranging studies to clarify their potential value for the current neuropharmacology of anxiety disorders. ",
keywords = "Anxiety, Carbon monoxide, Hydrogen sulfide, Nitric oxide",
author = "A. Pa{\l}asz and I.C. Menezes and J.J. Worthington",
note = "The final publication is available at Springer via http://dx.doi.org/10.1007/s43440-021-00242-2",
year = "2021",
month = mar,
day = "13",
doi = "10.1007/s43440-021-00242-2",
language = "English",
volume = "73",
pages = "357–371",
journal = "Pharmacological reports : PR",
issn = "1734-1140",
publisher = "Polish Academy of Sciences Publishing House",

}

RIS

TY - JOUR

T1 - The role of brain gaseous neurotransmitters in anxiety

AU - Pałasz, A.

AU - Menezes, I.C.

AU - Worthington, J.J.

N1 - The final publication is available at Springer via http://dx.doi.org/10.1007/s43440-021-00242-2

PY - 2021/3/13

Y1 - 2021/3/13

N2 - Although anxiety is perhaps one of the most significant current medical and social problems, the neurochemical mechanistic background of this common condition remains to be fully understood. Multifunctional regulatory gasotransmitters are novel, atypical inorganic factors of the brain that are involved in the mechanisms of anxiety responses. Nitric oxide (NO) signaling shows ambiguous action in animal models of anxiety, while NO donors exert anxiogenic or anxiolytic effect depending on their chemical structure, dose, treatment schedule and gas release rapidity. The majority of NO synthase inhibitors act as a relatively potent axiolytic agents, while hydrogen sulfide (H2S) and carbon monoxide (CO) delivered experimentally in the form of “slow” or “fast” releasing donors have recently been considered as anxiolytic neurotransmitters. In this comprehensive review we critically summarize the literature regarding the intriguing roles of NO, H2S and CO in the neuromolecular mechanisms of anxiety in the context of their putative, yet promising therapeutic application. A possible mechanism of gasotransmitter action at the level of anxiety-related synaptic transmission is also presented. Brain gasesous neuromediators urgently require further wide ranging studies to clarify their potential value for the current neuropharmacology of anxiety disorders.

AB - Although anxiety is perhaps one of the most significant current medical and social problems, the neurochemical mechanistic background of this common condition remains to be fully understood. Multifunctional regulatory gasotransmitters are novel, atypical inorganic factors of the brain that are involved in the mechanisms of anxiety responses. Nitric oxide (NO) signaling shows ambiguous action in animal models of anxiety, while NO donors exert anxiogenic or anxiolytic effect depending on their chemical structure, dose, treatment schedule and gas release rapidity. The majority of NO synthase inhibitors act as a relatively potent axiolytic agents, while hydrogen sulfide (H2S) and carbon monoxide (CO) delivered experimentally in the form of “slow” or “fast” releasing donors have recently been considered as anxiolytic neurotransmitters. In this comprehensive review we critically summarize the literature regarding the intriguing roles of NO, H2S and CO in the neuromolecular mechanisms of anxiety in the context of their putative, yet promising therapeutic application. A possible mechanism of gasotransmitter action at the level of anxiety-related synaptic transmission is also presented. Brain gasesous neuromediators urgently require further wide ranging studies to clarify their potential value for the current neuropharmacology of anxiety disorders.

KW - Anxiety

KW - Carbon monoxide

KW - Hydrogen sulfide

KW - Nitric oxide

U2 - 10.1007/s43440-021-00242-2

DO - 10.1007/s43440-021-00242-2

M3 - Journal article

VL - 73

SP - 357

EP - 371

JO - Pharmacological reports : PR

JF - Pharmacological reports : PR

SN - 1734-1140

ER -