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The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat

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The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat. / Fu, G.; Dai, J.; Li, Z. et al.
In: Toxicology and Applied Pharmacology, Vol. 404, 115151, 01.10.2020.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Fu, G, Dai, J, Li, Z, Chen, F, Liu, L, Yi, L, Teng, Z, Quan, C, Zhang, L, Zhou, T, Donkersley, P, Song, S & Shi, Y 2020, 'The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat', Toxicology and Applied Pharmacology, vol. 404, 115151. https://doi.org/10.1016/j.taap.2020.115151

APA

Fu, G., Dai, J., Li, Z., Chen, F., Liu, L., Yi, L., Teng, Z., Quan, C., Zhang, L., Zhou, T., Donkersley, P., Song, S., & Shi, Y. (2020). The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat. Toxicology and Applied Pharmacology, 404, Article 115151. https://doi.org/10.1016/j.taap.2020.115151

Vancouver

Fu G, Dai J, Li Z, Chen F, Liu L, Yi L et al. The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat. Toxicology and Applied Pharmacology. 2020 Oct 1;404:115151. Epub 2020 Jul 22. doi: 10.1016/j.taap.2020.115151

Author

Fu, G. ; Dai, J. ; Li, Z. et al. / The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat. In: Toxicology and Applied Pharmacology. 2020 ; Vol. 404.

Bibtex

@article{58de82c2dfcf4c14b71738113cf61cc8,
title = "The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat",
abstract = "Di (2-ethylhexyl) phthalate (DEHP) is a known environmental endocrine disruptor that impairs development of testis and spermatogenesis. This study aims to explore the effects of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat. 24 6-week-old male Sprague-Dawley rats were randomly divided into 4 groups (Control, low-dose, middle-dose and high-dose group) and were treated with increasing concentration of DEHP (0, 250, 500, 1000 mg/kg/day) respectively for 28 consecutive days by intragastric administration. Our results showed that DEHP exposure induced obvious morphological changes of testis, decreased organ coefficient of testis and sperm count, and increased testicular cell apoptosis in the 500 and 1000 mg/kg/day DEHP groups.",
keywords = "Di (2-ethylhexyl) phthalate, PI3K-Akt-mTOR, Puberty, Reproductive toxicology, STAT3/p53",
author = "G. Fu and J. Dai and Z. Li and F. Chen and L. Liu and L. Yi and Z. Teng and C. Quan and L. Zhang and T. Zhou and P. Donkersley and S. Song and Y. Shi",
year = "2020",
month = oct,
day = "1",
doi = "10.1016/j.taap.2020.115151",
language = "English",
volume = "404",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat

AU - Fu, G.

AU - Dai, J.

AU - Li, Z.

AU - Chen, F.

AU - Liu, L.

AU - Yi, L.

AU - Teng, Z.

AU - Quan, C.

AU - Zhang, L.

AU - Zhou, T.

AU - Donkersley, P.

AU - Song, S.

AU - Shi, Y.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Di (2-ethylhexyl) phthalate (DEHP) is a known environmental endocrine disruptor that impairs development of testis and spermatogenesis. This study aims to explore the effects of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat. 24 6-week-old male Sprague-Dawley rats were randomly divided into 4 groups (Control, low-dose, middle-dose and high-dose group) and were treated with increasing concentration of DEHP (0, 250, 500, 1000 mg/kg/day) respectively for 28 consecutive days by intragastric administration. Our results showed that DEHP exposure induced obvious morphological changes of testis, decreased organ coefficient of testis and sperm count, and increased testicular cell apoptosis in the 500 and 1000 mg/kg/day DEHP groups.

AB - Di (2-ethylhexyl) phthalate (DEHP) is a known environmental endocrine disruptor that impairs development of testis and spermatogenesis. This study aims to explore the effects of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat. 24 6-week-old male Sprague-Dawley rats were randomly divided into 4 groups (Control, low-dose, middle-dose and high-dose group) and were treated with increasing concentration of DEHP (0, 250, 500, 1000 mg/kg/day) respectively for 28 consecutive days by intragastric administration. Our results showed that DEHP exposure induced obvious morphological changes of testis, decreased organ coefficient of testis and sperm count, and increased testicular cell apoptosis in the 500 and 1000 mg/kg/day DEHP groups.

KW - Di (2-ethylhexyl) phthalate

KW - PI3K-Akt-mTOR

KW - Puberty

KW - Reproductive toxicology

KW - STAT3/p53

U2 - 10.1016/j.taap.2020.115151

DO - 10.1016/j.taap.2020.115151

M3 - Journal article

VL - 404

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

M1 - 115151

ER -