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The role of TGF-βs in mammalian development and neoplasia

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The role of TGF-βs in mammalian development and neoplasia. / Akhurst, Rosemary J.; Fitzpatrick, David R.; Fowlis, Deborah J. et al.

In: Molecular Reproduction and Development, Vol. 32, No. 2, 06.1992, p. 127-135.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Akhurst, RJ, Fitzpatrick, DR, Fowlis, DJ, Gatherer, D, Millan, FA & Slager, H 1992, 'The role of TGF-βs in mammalian development and neoplasia', Molecular Reproduction and Development, vol. 32, no. 2, pp. 127-135. https://doi.org/10.1002/mrd.1080320208

APA

Akhurst, R. J., Fitzpatrick, D. R., Fowlis, D. J., Gatherer, D., Millan, F. A., & Slager, H. (1992). The role of TGF-βs in mammalian development and neoplasia. Molecular Reproduction and Development, 32(2), 127-135. https://doi.org/10.1002/mrd.1080320208

Vancouver

Akhurst RJ, Fitzpatrick DR, Fowlis DJ, Gatherer D, Millan FA, Slager H. The role of TGF-βs in mammalian development and neoplasia. Molecular Reproduction and Development. 1992 Jun;32(2):127-135. doi: 10.1002/mrd.1080320208

Author

Akhurst, Rosemary J. ; Fitzpatrick, David R. ; Fowlis, Deborah J. et al. / The role of TGF-βs in mammalian development and neoplasia. In: Molecular Reproduction and Development. 1992 ; Vol. 32, No. 2. pp. 127-135.

Bibtex

@article{682453f60e86482f9fccd4d58b99ef58,
title = "The role of TGF-βs in mammalian development and neoplasia",
abstract = "To date, three mammalian TGF-beta isoforms have been identified, each encoded by different genetic loci. Through each is very similar in primary amino acid structure, there are clear differences both in the mature bioactive peptide region and in the latency-associated peptide, which could potentially confer differential biological specificity.As one route to investigate differential biological function in vivo we have used gene specific probes for in situ hybridization studies to examine the distribution of RNA transcripts during mammalian embryogenesis. Mouse embryos from 6 to 14.5 gestational age and human embryos from 32 to 57 days post-fertilization have been probed. A general conclusion from these studies is that each TGF-beta gene has a distinct, through overlapping, pattern of transcript distribution and that this pattern, in most cases, is conserved between mouse and man. We have focused on the biological function the TGF-betas play in certain epithelia and in cardiogenesis, which will be discussed in this presentation.",
keywords = "CARDIOGENESIS, EPITHELIA, MOUSE DEVELOPMENT, TGF-BETA, TRANSFORMING GROWTH-FACTOR, MOUSE EPIDERMIS, EXPRESSION, EMBRYO, CELLS, HEART, RNA, DIFFERENTIATION, PROLIFERATION, EMBRYOGENESIS",
author = "Akhurst, {Rosemary J.} and Fitzpatrick, {David R.} and Fowlis, {Deborah J.} and Derek Gatherer and Millan, {Fergus A.} and Hans Slager",
year = "1992",
month = jun,
doi = "10.1002/mrd.1080320208",
language = "English",
volume = "32",
pages = "127--135",
journal = "Molecular Reproduction and Development",
issn = "1040-452X",
publisher = "Wiley-Liss Inc.",
number = "2",
note = "SYMP ON TGF-BETA AND RELATED PROTEINS IN DEVELOPMENT ; Conference date: 20-09-1991 Through 23-09-1991",

}

RIS

TY - JOUR

T1 - The role of TGF-βs in mammalian development and neoplasia

AU - Akhurst, Rosemary J.

AU - Fitzpatrick, David R.

AU - Fowlis, Deborah J.

AU - Gatherer, Derek

AU - Millan, Fergus A.

AU - Slager, Hans

PY - 1992/6

Y1 - 1992/6

N2 - To date, three mammalian TGF-beta isoforms have been identified, each encoded by different genetic loci. Through each is very similar in primary amino acid structure, there are clear differences both in the mature bioactive peptide region and in the latency-associated peptide, which could potentially confer differential biological specificity.As one route to investigate differential biological function in vivo we have used gene specific probes for in situ hybridization studies to examine the distribution of RNA transcripts during mammalian embryogenesis. Mouse embryos from 6 to 14.5 gestational age and human embryos from 32 to 57 days post-fertilization have been probed. A general conclusion from these studies is that each TGF-beta gene has a distinct, through overlapping, pattern of transcript distribution and that this pattern, in most cases, is conserved between mouse and man. We have focused on the biological function the TGF-betas play in certain epithelia and in cardiogenesis, which will be discussed in this presentation.

AB - To date, three mammalian TGF-beta isoforms have been identified, each encoded by different genetic loci. Through each is very similar in primary amino acid structure, there are clear differences both in the mature bioactive peptide region and in the latency-associated peptide, which could potentially confer differential biological specificity.As one route to investigate differential biological function in vivo we have used gene specific probes for in situ hybridization studies to examine the distribution of RNA transcripts during mammalian embryogenesis. Mouse embryos from 6 to 14.5 gestational age and human embryos from 32 to 57 days post-fertilization have been probed. A general conclusion from these studies is that each TGF-beta gene has a distinct, through overlapping, pattern of transcript distribution and that this pattern, in most cases, is conserved between mouse and man. We have focused on the biological function the TGF-betas play in certain epithelia and in cardiogenesis, which will be discussed in this presentation.

KW - CARDIOGENESIS

KW - EPITHELIA

KW - MOUSE DEVELOPMENT

KW - TGF-BETA

KW - TRANSFORMING GROWTH-FACTOR

KW - MOUSE EPIDERMIS

KW - EXPRESSION

KW - EMBRYO

KW - CELLS

KW - HEART

KW - RNA

KW - DIFFERENTIATION

KW - PROLIFERATION

KW - EMBRYOGENESIS

U2 - 10.1002/mrd.1080320208

DO - 10.1002/mrd.1080320208

M3 - Journal article

VL - 32

SP - 127

EP - 135

JO - Molecular Reproduction and Development

JF - Molecular Reproduction and Development

SN - 1040-452X

IS - 2

T2 - SYMP ON TGF-BETA AND RELATED PROTEINS IN DEVELOPMENT

Y2 - 20 September 1991 through 23 September 1991

ER -